Research Article
Therapeutic Effect of Hydroalcoholic Extract for Withania Coagulans for Diuretic Activity in Rodents
Rajesh Kumar Sharma,
Priyanka Chandolia,
Ravi Shankar Sundram,
Kumari Isha,
Sanjana Soni
Issue:
Volume 13, Issue 1, February 2024
Pages:
1-5
Received:
14 July 2023
Accepted:
16 August 2023
Published:
8 January 2024
Abstract: Diuretics are used to manage fluid excess as part of a treatment strategy. Withania coagulans has long been utilised in traditional medicine. Including some slight modifications and by using furosemide as a standard drug, in vitro cell Lipchitz test model was used to examine a diuretic effectiveness of Withania coagulans fruit aqueous extract. Results demonstrated that only one unique route of oral dosage delivery of hydroalcoholicextract of fruit of Withania Coagulans as 500 mg/kg/b. w. and 750 mg/Kg and standard Furosemide (10 mg/kg) have enhanced the amount of urine produced as well as an increase in the amounts of sodium, potassium, and chloride ions in urine. Hydro alcoholic extract of fruit of Withania Coagulans 750 mg/kg produced a higher diuretic activity equivalent to that low dose extract and lower diuretic effect when comparable with furosemide (10 mg/kg) as a standard. The herb is utilised in traditional medicine for its diuretic properties. Thus, our study backs up and validates the logic for the folkloric usage of roots of Hydro alcoholic extract of fruit of Withania Coagulans for its diuretic activity. Withanolides isolated from ethanolic extract demonstrated antifungal, antibiotic, and anti-tumor activity. Comparing Withania species, withanolides are more polar in nature.
Abstract: Diuretics are used to manage fluid excess as part of a treatment strategy. Withania coagulans has long been utilised in traditional medicine. Including some slight modifications and by using furosemide as a standard drug, in vitro cell Lipchitz test model was used to examine a diuretic effectiveness of Withania coagulans fruit aqueous extract. Resu...
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Case Report
Crossed Cerebellar Diaschisis and Cerebral Infarction After Cerebral Hyperperfusion Syndrome Following Carotid Artery Stenting: A Case Report
Wei-Qin Ning,
Si-Qi Chen,
Sheng-Peng Diao,
Shui-Sheng Zhong*
Issue:
Volume 13, Issue 1, February 2024
Pages:
13-16
Received:
28 December 2023
Accepted:
23 January 2024
Published:
21 February 2024
Abstract: Crossed cerebellar diaschisis (CCD) often occurs after ischemic or hemorrhagic stroke that does great damage to the cortico-ponto-cerebellar pathway (CPCP). Nevertheless, as far as we know, CCD due to cerebral hyperperfusion syndrome (CHS) following carotid artery stenting (CAS) is rare. We report a case where CCD and new cerebral infarction after CHS following CAS was effectively treated by intravenous use of edaravone and mannitol. The patient was a 74-year-old female. She developed dizziness and vomiting accompanied with weakness of the right limb for 8 days and was admitted to our hospital. Computed tomography angiography scan revealed severe stenosis at the beginning of the left internal carotid artery. Further digital subtraction angiography (DSA) revealed severe stenosis at the beginning of the left internal carotid artery, with a stenosis rate of approximately 90%. Therefore, she underwent left CAS implantation. After the operation, the patient developed disturbance of consciousness and decreased muscle strength in the right limb. Intravenous infusion of edaravone and mannitol were then started. After 10 days of medical treatment, the condition of patient improved to mild hemiparesis. The findings in this present case strongly suggest that CHS after CAS for carotid artery stenosis may cause transient CCD.
Abstract: Crossed cerebellar diaschisis (CCD) often occurs after ischemic or hemorrhagic stroke that does great damage to the cortico-ponto-cerebellar pathway (CPCP). Nevertheless, as far as we know, CCD due to cerebral hyperperfusion syndrome (CHS) following carotid artery stenting (CAS) is rare. We report a case where CCD and new cerebral infarction after ...
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