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Presumed Recent-Onset Refractory Status Epilepticus (NORSE) Post-COVID-19 Plasmapheresis and Itolizumab: Case Report
Idamis Fernandez Jure,
Armando Caballero Lopez,
Tania Crombet Ramos,
Julio Cesar Alegria Cruz
Issue:
Volume 11, Issue 4, July 2022
Pages:
92-94
Received:
15 June 2022
Accepted:
6 July 2022
Published:
18 July 2022
DOI:
10.11648/j.cmr.20221104.11
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Abstract: Introduction: Recent-onset refractory status epilepticus (NORSE) is a neurological emergency that leads to morbidity and mortality, with rapid evolution, poor prognosis; uncommon entity in patients without active epilepsy, without clear acute or active structural, toxic or metabolic cause; and not associated with any etiology. The management of this disease is not clearly defined and has been poorly described so far in the literature. Cases of NORSE associated with COVID-19 illness have been reported. However, the frequency related to SARS-CoV-2 infection is unknown, it is a novel case in our environment. Objective: to evaluate the effectiveness of therapeutic plasmapheresis and Itolizumab as coadjuvant therapy in the treatment of this entity. Methodology: Our research reports a case of a young patient with a history of previous health, admitted to the intensive care unit of the Arnaldo Milián Castro Hospital, in February of this year, due to repetitive seizures that are difficult to control, with a precedent of respiratory manifestations. acute (runny nose) the week before; to the course of the NORSE, it was direct contact of a confirmed case to COVID-19; Due to the fact that there are pathogenic substances in the plasma that contribute to the disease process, plasmapheresis and treatment with Itolizumab are proposed to support the therapy of this entity. Conclusions: Therapeutic plasmapheresis and itolizumab constituted a correct approach in the treatment of this clinical condition associated with presumptive post-COVID-19.
Abstract: Introduction: Recent-onset refractory status epilepticus (NORSE) is a neurological emergency that leads to morbidity and mortality, with rapid evolution, poor prognosis; uncommon entity in patients without active epilepsy, without clear acute or active structural, toxic or metabolic cause; and not associated with any etiology. The management of thi...
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The Cardiometabolic Burden of Sedentarism and Its Implications on Health
Issue:
Volume 11, Issue 4, July 2022
Pages:
95-101
Received:
15 June 2022
Accepted:
4 July 2022
Published:
18 July 2022
DOI:
10.11648/j.cmr.20221104.12
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Abstract: Sedentary behavior is spreading in society, a phenomenon especially aggravated by the rise of modern technology. Sedentary lifestyle habits are being adopted by young people, who increase the time they spend in stationary activities like video games, TV and, most recently handheld digital devices like smartphones and tablets. Today many daily activities can be carried out without greater muscular activity, transforming an active and dynamic being into a sedentary one, with less energy expenditure. It has been demonstrated that both sedentary behavior and physical inactivity impact negatively on cardiometabolic well-being, and they become a serious problem for public health, as it has been claimed in several studies and by scientific statements. People need to reduce the amount of time they waste being sedentary, especially during infancy and youthhood to avoid the increase in cardiometabolic risk during adulthood and reach the advanced age with a better functional capacity and more active. Further observational and experimental studies are needed to define relationships between total sedentary time and patterns of sedentary time with biomarkers of cardiometabolic risk and its impact on health outcomes. This review intends to outline the facts of sedentarism as a cardiometabolic risk factor specially in youngest people and claim for more attention by medical care to this problem.
Abstract: Sedentary behavior is spreading in society, a phenomenon especially aggravated by the rise of modern technology. Sedentary lifestyle habits are being adopted by young people, who increase the time they spend in stationary activities like video games, TV and, most recently handheld digital devices like smartphones and tablets. Today many daily activ...
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Western China Classification and Minimally Invasive Surgical Treatment Strategies of the Multiple Ligament Injury Knee
Yang Songyun,
Li Gangchi,
Chen Gang,
He Xingchuan
Issue:
Volume 11, Issue 4, July 2022
Pages:
102-108
Received:
27 June 2022
Accepted:
13 July 2022
Published:
22 July 2022
DOI:
10.11648/j.cmr.20221104.13
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Abstract: Objective: 1. Multiple ligament injuries of the knee (MLIK) often lead to severe injury, with high dysfunctiong but there is no special classification and corresponding minimally invasive surgical treatment strategy for MLIK, so according to the different degrees of the multiple ligament injury knee, summarize the different types of the multiple ligament injury knee, and develop a systematic classification method suitable for clinical surgeons to quickly understand and master; 2. According to the classification results of the multiple ligament injury knee, the corresponding minimally invasive surgical treatment strategies were developed to facilitate clinicians to make accurate judgment and treatment in a timely manner. Methods: 30 cases of the multiple ligament injury knee were summarized in our hospital, and the preliminary classification and minimally invasive surgical treatment strategies were proposed. A total of 50 cases of patients with the multiple ligament injury knee were collected in our hospital. Diagnosis and treatment were conducted according to the preliminary classification and surgical treatment strategies summarized in the early stage. The classification diagnosis and treatment effect were verified after the operation according to knee function score, etc., and the modification was carried out in stages. Finally, 80 cases of multiple ligament injuries of knee joint were summarized. Results: A systematic classification method and minimally invasive surgical treatment strategy were developed for the multiple ligament injury knee. Conclusion: The classification method and minimally nvasive surgical treatment strategy for the multiple ligament injury knee are convenient for general clinical surgeons to quickly understand and master, make accurate judgment and treatment, and suitable for clinical popularization and application.
Abstract: Objective: 1. Multiple ligament injuries of the knee (MLIK) often lead to severe injury, with high dysfunctiong but there is no special classification and corresponding minimally invasive surgical treatment strategy for MLIK, so according to the different degrees of the multiple ligament injury knee, summarize the different types of the multiple li...
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IRF8 Deleterious Single Nucleotide Variations Are Associated with Unfavorable Survival of Patients with Skin Cutaneous Melanoma
Issue:
Volume 11, Issue 4, July 2022
Pages:
109-113
Received:
18 August 2022
Accepted:
25 August 2022
Published:
27 August 2022
DOI:
10.11648/j.cmr.20221104.14
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Abstract: Interferon regulatory factor 8 (IRF8) is a transcription factor involved in the differentiation of myeloid progenitors. In the current study, we aimed to explore the correlation between IRF8 expression and immune cell infiltration in skin cutaneous melanoma, the single nucleotide variants (SNVs) of this gene, and their association with survival outcomes. Analyses are performed using data from The Cancer Genome Atlas (TCGA)-Skin Cutaneous Melanoma (SKCM), with the platform of Gene Set Cancer Analysis (GSCA). IRF8 expression has an infiltration score of 0.7, suggesting a strong correlation with immune cell infiltration. IRF8 expression had strong positive correlations (Pearson's r ≥ -0.6) with the infiltration of CD4+ T, CD8+ T, Central memory T, Cytotoxic T, T follicular helper, Th1 and induced Tregs cells but presented a strong negative correlation (Pearson's r ≤ -0.6) with the infiltration of Neutrophil cells. 8 out of 468 cases (1.71%) in TCGA-SKCM have deleterious SNVs. The IRF8 mutant group harboring these mutations had significantly shorter progression-free survival (P = 0.03), disease-specific survival (P = 0.0065), and overall survival (P = 0.039) compared to the group with wild-type IRF8. In summary, IRF8 expression might serve as an immune cell infiltration marker in skin cutaneous melanoma. IRF8 deleterious SNVs are associated with significantly worse prognosis. In the future, it is meaningful to validate the link between these mutations and immunotherapy responses.
Abstract: Interferon regulatory factor 8 (IRF8) is a transcription factor involved in the differentiation of myeloid progenitors. In the current study, we aimed to explore the correlation between IRF8 expression and immune cell infiltration in skin cutaneous melanoma, the single nucleotide variants (SNVs) of this gene, and their association with survival out...
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Influence of Bicycle Ergometric Loads on the Energy Supply System in Patients After Surgery with an Artificial Circulation
Kuular Arzhana Makarovna,
Kakuchaya Tea Tamazovna,
Dzhitava Tamara Georgievna,
Pachuashvili Nona Vazhaevna,
Filatova Angelina Gennadevna
Issue:
Volume 11, Issue 4, July 2022
Pages:
114-119
Received:
9 January 2022
Accepted:
4 February 2022
Published:
29 August 2022
DOI:
10.11648/j.cmr.20221104.15
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Abstract: The reduction in the risk of repeated hospitalizations was revealed against the background of ongoing cardiac rehabilitation after CABG. A number of studies have revealed a reduction in the risk of repeated hospitalizations on the background of ongoing cardiac rehabilitation after CABG. Physical cardiorehabilitation is an effective means of restoring the adaptive capabilities of the organism. The goal of the cardiorehabilitation training program after cardiac surgery is optimization of energy supply systems. Objective: To study the effectiveness of the optimal сardiac rehabilitation program for the lactate system in cardiac patients. Methods: We examined 36 patients undergoing coronary artery bypass grafting under conditions of artificial circulation, with an IR duration of 56 ± 20.5 minutes, were divided into two groups: a control group (n = 15) - without performing bicycle ergometric, the age of 54.2 ± 1.4 years, the main group (n = 21) - with the exercise of the bicycle ergometric load at the age of 53.9 ± 1.3 years (p> 0.05). Of these, 17 men (62.5%), 14 women (37.5%). Gender was not considered. Anaerobic exercise carried out on exercise bikes SCHILLER 10 days after CABG. The load power was from 25 to 70-90 W. Before cardiorehabilitation estimated lactate, glucose, pH, PCO2, pO2, BE blood before and after the load ergometric data of external respiration, heart rate and blood pressure. After the rehabilitation course, the above parameters were evaluated. Results: When assessing the indices in the basis of the group at the end of the course of cardiac rehabilitation, a significant decrease in systolic blood pressure after exercise is 155 ± 5.7 mm Hg. (P <0.05), an increase in the value of VO2peak to 19.0 ± 0.9 ml / kg / min (p <0.05), lactate in the blood decreased to 1.7 ± 0.2 mmol / l (p <0.05). There were no significant changes in pH, blood glucose, or heart rate. Conclusions: Analysis of the results showed that a properly fitted load ergometric parameters can optimize the anaerobic glycolysis in patients undergoing surgery with cardiopulmonary bypass, as well as increase the functionality of patients.
Abstract: The reduction in the risk of repeated hospitalizations was revealed against the background of ongoing cardiac rehabilitation after CABG. A number of studies have revealed a reduction in the risk of repeated hospitalizations on the background of ongoing cardiac rehabilitation after CABG. Physical cardiorehabilitation is an effective means of restori...
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