Classification of Incident Types of Hematologic Malignancy Using Discriminant Analysis at Kinshasa University Clinics, DR Congo
Mireille Solange Nkanga Nganga,
Benjamin Longo-Mbenza,
Fons Verdonck,
Branly Kilola Mbunga,
Aimé Tshiyamu Mbaya,
Christian Lueme Lokatola,
Teke Apalata,
Jean-Marie Ntumba Kayembe,
Georges Lelo Mvumbi,
Blaise Matondo Ma Nzambi Sumbu,
Alain Nzonzila Nganga,
David Muballe,
Cecile Roth Laure Miakassissa Mapapa,
Paul Roger Kazadi Beia,
Aurore Cecilia Orphée Mbombo Beia,
Donatien Nzongola Nkasu Kayembe
Issue:
Volume 8, Issue 3, May 2019
Pages:
56-62
Received:
29 November 2018
Accepted:
29 January 2019
Published:
22 July 2019
Abstract: The objective of this study was to identify important biomarker differences between absence of HM and expected morphopathologic types of HM. A retrospective analysis study of adult patients aged ≥ 20 years was managed by cytologic aspects such as normal myelogram vs. HM types between 2009 and 2015. Out of 105 patients, 63 (60%) experienced incident HM while 42, 14, 18, 10, 10, 6, and 5 patients had normal myelogram, multiple myeloma (MM), acute myeloid leukaemia (AML), myelodysplastic syndromes (MDS), chronic myeloid leukaemia (CML), acute myeloid leukaemia (CLL) and acute lymphoid leukaemia (ALL), respectively. In Discriminant Analysis (DA), only levels of transfusion, Hb, and WCC discriminated significantly (Wilks lambda =0.159; P < 0.0001) the study groups through Function 1 [Eigen value (EV) = 2.591; cumulative variance (CV) = 78, 7% and Canonical correlation (CC) = 0.849], Function 2 (EV = 0.619; CV = 97.5%; CC = 0.618), and Function 3 (EV = 0.081; CV = 100%; CC = 0.274). The highest Mahalanobis distance (Min D Squared = 0.162) was observed between CML and MDS. For early diagnosis, precise medicine, and good practice in hematologic oncology, DA separated CML, MDS, MM, AML, CLL, and ALL from normal myelogram in Congolese patients.
Abstract: The objective of this study was to identify important biomarker differences between absence of HM and expected morphopathologic types of HM. A retrospective analysis study of adult patients aged ≥ 20 years was managed by cytologic aspects such as normal myelogram vs. HM types between 2009 and 2015. Out of 105 patients, 63 (60%) experienced incident...
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Effects of Yaji on Some Biochemical and Haematological Indices in Albino Wistar Rats
Chilaka Ugochinyere Jane,
Chilaka Kingsley Chimsorom,
Meludu Samuel,
Chukwu Leoclincton
Issue:
Volume 8, Issue 3, May 2019
Pages:
63-68
Received:
3 June 2019
Accepted:
9 August 2019
Published:
26 August 2019
Abstract: Yaji is a mixture of spices and additives that is used as sauce for meat delicacy in Nigeria called suya. Its effects on the body weight, index of liver function, on lipid profile, kidney function and some haematological indices were the main focus of this study. A total of 50 Wistar rats with average weight of 200grams were randomly divided into five experimental groups: A, B, C, D and E. Each group consisted of ten animals. Baseline blood sample was collected from each animal. Group A was the control group while groups B to E were the treatment groups. Group A was given 100% chicken mesh, group B with 75% of chicken mesh + 25% of Yaji, group C with 50% of chicken mesh + 50% of Yaji, group D with 25% of chicken mesh + 75% of Yaji, group E with 100% of Yaji. The experiment lasted for 30days. There was a significant increase in some atherosclerotic index: Total Cholesterol (TC) and Triglyceride (TG), while the level of Low Density Lipoprotein (LDL) only increased at very high percentage of Yaji intake but High Density Lipoprotein (HDL) increased at moderate intake of Yaji. Sodium and Chloride ions were significantly increased while Potassium and Bicarbonate ions decreased significantly compared to the controls with urea and creatinine levels remaining unchanged. There was also a significant decrease in Packed Cell Volume (PCV) as the proportion of Yaji increased in relation to their feed while White Blood Cell Counts, total and differential were unchanged. The changes in weight did not show any statistical difference from the control. The consumption of the meat sauce, Yaji and its spices may have adverse health implications if consumed in higher quantity than the normal diet and therefore should be consumed only occasionally.
Abstract: Yaji is a mixture of spices and additives that is used as sauce for meat delicacy in Nigeria called suya. Its effects on the body weight, index of liver function, on lipid profile, kidney function and some haematological indices were the main focus of this study. A total of 50 Wistar rats with average weight of 200grams were randomly divided into f...
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