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Elastic Intramedullary Nail Drainage in the Treatment of Long Bone Cyst with Pathological Fracture in Children
Issue:
Volume 12, Issue 3, May 2023
Pages:
48-51
Received:
5 January 2023
Accepted:
29 January 2023
Published:
18 May 2023
Abstract: Background: Unilateral bone cyst (UBC) is a common lesion in children. Currently, the commonly used treatment methods for UBC have the defects of large surgical trauma and high recurrence rate. Objective: To investigate the effect of elastic intramedullary nail in the treatment of long bone cyst in children with pathological fracture. Methods: 11 patients with pathological fracture long bone cyst were treated with elastic intramedullary nail. There are 7 men and 4 women. The age ranged from 6 to 12 years, with a mean age of 7.6 years. There were 3 cases of proximal humerus, 2 cases of middle humerus, 1 case of whole humerus, 2 cases of proximal femur, 1 case of middle femur, and 2 cases of middle tibia. Results: t test was performed on the remaining static penetration area of the cyst measured at two adjacent time points using SPSS25 statistical software. P < 0.05 was considered statistically significant. Results All the 11 patients were followed up for 4 to 24 months, with an average of 12 months. The cyst healed in 4 cases (36.3%), the defect healed in 4 cases (36.3%), the healing rate was 72.7%, and 3 cases were sustained (1 case was followed up for 4 months). Discussion: Minimally invasive elastic nail fixation is effective in the treatment of bone cyst. However, the limitations of this study are influenced by the duration of follow-up, which is still ongoing for some UBC children. Long-term elastic titanium intramedullary nail implantation in the treatment of long bone cyst has the characteristics of single intervention, small injury, good stability and prevention of pathological fracture.
Abstract: Background: Unilateral bone cyst (UBC) is a common lesion in children. Currently, the commonly used treatment methods for UBC have the defects of large surgical trauma and high recurrence rate. Objective: To investigate the effect of elastic intramedullary nail in the treatment of long bone cyst in children with pathological fracture. Methods: 11 p...
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A Fetus with 17p13.3 Deletion and 15q24.1q26.3 Duplication Derived from a Paternal Balance Translocation t (15; 17) (q24; p13)
Yinghui Dang,
Shanning Wan,
Yunyun Zheng,
Ying Xu,
Jia Li,
Hong Yang
Issue:
Volume 12, Issue 3, May 2023
Pages:
52-56
Received:
22 May 2023
Accepted:
17 June 2023
Published:
6 July 2023
Abstract: Background: We present prenatal diagnosis of a 17p13.3 deletion and 15q24.1q26.3 duplication associated with paternal chromosome balance translocation, and to illustrate the importance of early diagnosis ultrasound showed fetal structural abnormality and reduce the birth defects. Case presentation: A primigravid woman who 25-year-old underwent amniocentesis at 24weeks of gestation because of the ultrasound showed the head structure abnormal of fetus. The routine test indicates that the fetus is normal in early pregnancy. Karyotype analysis showed 46, XN, -17, der (17)t (15; 17) (q24.1; p13.3), chromosome microarray analysis (CMA) detected a duplication on chromosome 15 and a deletion on chromosome 17 of fetus. Furthermore, the results of chromosome karyotype analysis indicated that the maternal karyotype is normal and the paternal karyotype is a balanced translocation of 46, XY, t (15; 17) (q24; p13), which inherited to the fetus. The pregnant woman decided to terminate the pregnancy after counseling. Conclusions: CMA is useful in prenatal to diagnose of fetal chromosomal abnormalities in pregnancy with ultrasound showed fetal abnormal structure, CMA can’t detect balanced translocations, but can be found by karyotyping. The two methods are complement each other. In addition, for patients with balanced translocations, preimplantation genetic diagnosis may be an option, it not only relieves the pain of spontaneous abortion for patients but also avoids the birth of defective fetal.
Abstract: Background: We present prenatal diagnosis of a 17p13.3 deletion and 15q24.1q26.3 duplication associated with paternal chromosome balance translocation, and to illustrate the importance of early diagnosis ultrasound showed fetal structural abnormality and reduce the birth defects. Case presentation: A primigravid woman who 25-year-old underwent amni...
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DAPK Gene Methylation Application in the Early Diagnosis of Nasopharyngeal Cancer
Song Zhang,
Jiahui Tang,
Hongyan Yuan
Issue:
Volume 12, Issue 3, May 2023
Pages:
57-60
Received:
2 June 2023
Accepted:
21 June 2023
Published:
6 July 2023
Abstract: Background: Nasopharyngeal cancer is a tumor of high malignancy originating from the epithelial tissues of the nasopharynx, which is often misdiagnosed and missed due to insidious lesions and inconspicuous early symptoms, and is a serious threat to human health. The development mechanism of nasopharyngeal cancer is still not well understood. Death-associated protein kinase (DAPK) is a calcium- and calmodulin- dependent serine and threonine protein kinase, which is involved in the apoptotic process induced by interferon-γ, tumor necrosis factor-α, Fas, etc. and has a pro-apoptotic function. The expression of DAPK in nasopharyngeal cancer tissues was related to the methylation status of CpG islands in the promoter region of its gene. Methylation of DAPK gene may be related to the occurrence and development of nasopharyngeal carcinoma. Objectives: The purpose of this article is to investigate the application value of DAPK gene methylation in the early diagnosis of nasopharyngeal cancer. Method: Methylation-specific PCR, pyrophosphate sequencing, real-time quantitative PCR and Western Blot test were used to detect the methylation of DAPK gene and its expression status in the blood of patients with nasopharyngeal cancer and chronic rhinopharyngitis. Result: There was no significant difference in the methylation rate and expression of DAPK gene in the blood of patients with nasopharyngeal cancer and chronic rhinopharyngitis. Conclusion: DAPK gene methylation cannot be used as an indicator for early diagnosis of nasopharyngeal cancer.
Abstract: Background: Nasopharyngeal cancer is a tumor of high malignancy originating from the epithelial tissues of the nasopharynx, which is often misdiagnosed and missed due to insidious lesions and inconspicuous early symptoms, and is a serious threat to human health. The development mechanism of nasopharyngeal cancer is still not well understood. Death-...
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