Background and aims: Laboratory tests may play an important role in the follow-up of COVID-19 patients acting as indicators of risk for severity and death. This study aims to explore the significance of certain laboratory tests in the management of COVID-19 patients treated by an autologous novel stem cells cocktail plus standard care. Methods: The 69 hospitalized COVID-19 patients recruited in the experimental arm of a clinical trial [NCT04473170] were divided into moderate or severe groups as recommended by WHO. Initial and after 21 days of treatment, laboratory data were analyzed and compared for both groups. The variable association was analyzed using the symmetric Spearman correlation matrix. Multiple linear regression was used for biomarkers most described in COVID-19 by a multivariate study and disease severity association using relative risk (RR) to laboratory variables. Results: Positive and strong associations were evidenced between parameters related to coagulation and inflammation markers. We found the strongest positive relationship between the LDH enzyme and IL-6 (r=0.81), followed by D-dimer (r=0.70). The multivariate study showed a strong influence of D-dimer, IL-6, IgG, and ceruloplasmin on the increased LDH level, with a greater influence of the last (R=0.71, p<0.0001). RR showed a statistically significant and positive association with COVID-19 severity for WBC (RR=45.2); neutrophil/lymphocyte ratio (NLR) (RR=3.8); IL-6 (RR=1.6); lymphocyte/monocyte ratio (LMR) (RR=1.5); and RR=1.3 for platelets/lymphocyte ratio (PLR), ferritin, and LDH. Conclusions: Risk assessment of severity using this laboratory variable is important.
| Published in | Clinical Medicine Research (Volume 10, Issue 4) |
| DOI | 10.11648/j.cmr.20211004.15 |
| Page(s) | 133-141 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2021. Published by Science Publishing Group |
COVID-19, SARS-CoV-2, Clinical Decision-Making, Risk Assessment, Risk Factors, Prognosis, IL-6, LDH
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APA Style
Rivero-Jimenez Rene Antonio, Villegas-Valverde Carlos Agustin, Torres-Zambrano Gina Marcela, Abdelrazik Abeer, Haider Muhammad Touseef, et al. (2021). Severity-related Changes in Laboratory Results During Early Follow-up in COVID-19 Patients Treated with a Novel Cocktail of Stem Cells. Clinical Medicine Research, 10(4), 133-141. https://doi.org/10.11648/j.cmr.20211004.15
ACS Style
Rivero-Jimenez Rene Antonio; Villegas-Valverde Carlos Agustin; Torres-Zambrano Gina Marcela; Abdelrazik Abeer; Haider Muhammad Touseef, et al. Severity-related Changes in Laboratory Results During Early Follow-up in COVID-19 Patients Treated with a Novel Cocktail of Stem Cells. Clin. Med. Res. 2021, 10(4), 133-141. doi: 10.11648/j.cmr.20211004.15
AMA Style
Rivero-Jimenez Rene Antonio, Villegas-Valverde Carlos Agustin, Torres-Zambrano Gina Marcela, Abdelrazik Abeer, Haider Muhammad Touseef, et al. Severity-related Changes in Laboratory Results During Early Follow-up in COVID-19 Patients Treated with a Novel Cocktail of Stem Cells. Clin Med Res. 2021;10(4):133-141. doi: 10.11648/j.cmr.20211004.15
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Download@article{10.11648/j.cmr.20211004.15,
author = {Rivero-Jimenez Rene Antonio and Villegas-Valverde Carlos Agustin and Torres-Zambrano Gina Marcela and Abdelrazik Abeer and Haider Muhammad Touseef and Castillo-Aleman Yandy Marx and Ventura-Carmenate Yendry and Abdel Hadi Loubna and Bencomo-Hernandez Antonio Alfonso},
title = {Severity-related Changes in Laboratory Results During Early Follow-up in COVID-19 Patients Treated with a Novel Cocktail of Stem Cells},
journal = {Clinical Medicine Research},
volume = {10},
number = {4},
pages = {133-141},
doi = {10.11648/j.cmr.20211004.15},
url = {https://doi.org/10.11648/j.cmr.20211004.15},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.cmr.20211004.15},
abstract = {Background and aims: Laboratory tests may play an important role in the follow-up of COVID-19 patients acting as indicators of risk for severity and death. This study aims to explore the significance of certain laboratory tests in the management of COVID-19 patients treated by an autologous novel stem cells cocktail plus standard care. Methods: The 69 hospitalized COVID-19 patients recruited in the experimental arm of a clinical trial [NCT04473170] were divided into moderate or severe groups as recommended by WHO. Initial and after 21 days of treatment, laboratory data were analyzed and compared for both groups. The variable association was analyzed using the symmetric Spearman correlation matrix. Multiple linear regression was used for biomarkers most described in COVID-19 by a multivariate study and disease severity association using relative risk (RR) to laboratory variables. Results: Positive and strong associations were evidenced between parameters related to coagulation and inflammation markers. We found the strongest positive relationship between the LDH enzyme and IL-6 (r=0.81), followed by D-dimer (r=0.70). The multivariate study showed a strong influence of D-dimer, IL-6, IgG, and ceruloplasmin on the increased LDH level, with a greater influence of the last (R=0.71, pConclusions: Risk assessment of severity using this laboratory variable is important.},
year = {2021}
}
TY - JOUR T1 - Severity-related Changes in Laboratory Results During Early Follow-up in COVID-19 Patients Treated with a Novel Cocktail of Stem Cells AU - Rivero-Jimenez Rene Antonio AU - Villegas-Valverde Carlos Agustin AU - Torres-Zambrano Gina Marcela AU - Abdelrazik Abeer AU - Haider Muhammad Touseef AU - Castillo-Aleman Yandy Marx AU - Ventura-Carmenate Yendry AU - Abdel Hadi Loubna AU - Bencomo-Hernandez Antonio Alfonso Y1 - 2021/08/02 PY - 2021 N1 - https://doi.org/10.11648/j.cmr.20211004.15 DO - 10.11648/j.cmr.20211004.15 T2 - Clinical Medicine Research JF - Clinical Medicine Research JO - Clinical Medicine Research SP - 133 EP - 141 PB - Science Publishing Group SN - 2326-9057 UR - https://doi.org/10.11648/j.cmr.20211004.15 AB - Background and aims: Laboratory tests may play an important role in the follow-up of COVID-19 patients acting as indicators of risk for severity and death. This study aims to explore the significance of certain laboratory tests in the management of COVID-19 patients treated by an autologous novel stem cells cocktail plus standard care. Methods: The 69 hospitalized COVID-19 patients recruited in the experimental arm of a clinical trial [NCT04473170] were divided into moderate or severe groups as recommended by WHO. Initial and after 21 days of treatment, laboratory data were analyzed and compared for both groups. The variable association was analyzed using the symmetric Spearman correlation matrix. Multiple linear regression was used for biomarkers most described in COVID-19 by a multivariate study and disease severity association using relative risk (RR) to laboratory variables. Results: Positive and strong associations were evidenced between parameters related to coagulation and inflammation markers. We found the strongest positive relationship between the LDH enzyme and IL-6 (r=0.81), followed by D-dimer (r=0.70). The multivariate study showed a strong influence of D-dimer, IL-6, IgG, and ceruloplasmin on the increased LDH level, with a greater influence of the last (R=0.71, pConclusions: Risk assessment of severity using this laboratory variable is important. VL - 10 IS - 4 ER -
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