@article{10.11648/j.cmr.20211004.16,
  author = {Nur Jahan Aktar and Milton Barua and Amanat Ullah and Abdus Sattar and Shoman Sarkar and Sujat Paul and Shofiur Rahman and Mitan Chakma and Mahmudul Islam Talukder and Mahatabur Rahman and Mohammad Faisal Kabir},
  title = {Clinical Presentations, Outcome and Cost of Illness of Dengue in a Tertiary Care Hospital of Bangladesh: An Observational Study},
  journal = {Clinical Medicine Research},
  volume = {10},
  number = {4},
  pages = {142-150},
  doi = {10.11648/j.cmr.20211004.16},
  url = {https://doi.org/10.11648/j.cmr.20211004.16},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.cmr.20211004.16},
  abstract = {Background: Dengue is a fast-emerging viral disease in many parts of the world, having a potential to present with a varied spectrum of clinical manifestations with atypical presentations being more frequent. This study was conducted to evaluate the clinical features, outcome and Cost of Illness (COI) of dengue cases admitted in a tertiary-care government hospital in Chattogram, Bangladesh. Methods & materials: It was a hospital based prospective observational study and was carried out in the Department of Medicine, Chittagong Medical College Hospital. All the consecutive serologically positive (NS1 antigen, IgM, IgG antibodies) dengue cases (age >12 years) admitted in the Department of Medicine of Chittagong Medical College Hospital from 1st August 2019 to 31st July 2020, were enrolled in the study. Severity of each dengue case was determined as per the recent WHO classification (2009) Clinical presentations of the cases were carefully assessed. In-hospital outcomes of the patients in terms of mortality, duration of hospital stay, need for ICU or other support were recorded. The COI questionnaire included three major cost components: direct medical costs (DMC), direct non-xiv medical costs (DNMC), and indirect costs (IC). Data analysis was done on the SPSS 23 version. Results: Out of 425 patients, the maximum number of dengue cases reported were males (76.9%) and belonging to the 21-30 years age group (38.8%). Fever was the main complaint in all the cases followed by headache (78%), myalgia (56%), persistent vomiting (44%). Of the 91.5% Dengue fever cases, 88.2% were classified as Dengue fever without warning signs and 3.3% with warning signs and 8.5% as severe dengue. Thrombocytopenia was present in 53.9% and leukopenia in 42.1% of cases. 3.3% of patients needed ICU admission and the mortality rate was 1.2%. The median total COI was BDT 8703 (IQR: 6240-11795) with median DMC of 3580 (IQR: 2525-4885), DNMC of 2000 (IQR: 1250-3225) and INMC of 2400 (IQR: 1045-4000). Conclusions: Overwhelming number of cases and their varied clinical presentations lead to an increase in hospitalization in this outbreak. Though the outcomes have been mostly favorable, the cost incurred as a result has been immense and has impacted households greatly, since most medical costs in Bangladesh are out-of-pocket expenses.},
 year = {2021}
}

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TY  - JOUR
T1  - Clinical Presentations, Outcome and Cost of Illness of Dengue in a Tertiary Care Hospital of Bangladesh: An Observational Study
AU  - Nur Jahan Aktar
AU  - Milton Barua
AU  - Amanat Ullah
AU  - Abdus Sattar
AU  - Shoman Sarkar
AU  - Sujat Paul
AU  - Shofiur Rahman
AU  - Mitan Chakma
AU  - Mahmudul Islam Talukder
AU  - Mahatabur Rahman
AU  - Mohammad Faisal Kabir
Y1  - 2021/08/09
PY  - 2021
N1  - https://doi.org/10.11648/j.cmr.20211004.16
DO  - 10.11648/j.cmr.20211004.16
T2  - Clinical Medicine Research
JF  - Clinical Medicine Research
JO  - Clinical Medicine Research
SP  - 142
EP  - 150
PB  - Science Publishing Group
SN  - 2326-9057
UR  - https://doi.org/10.11648/j.cmr.20211004.16
AB  - Background: Dengue is a fast-emerging viral disease in many parts of the world, having a potential to present with a varied spectrum of clinical manifestations with atypical presentations being more frequent. This study was conducted to evaluate the clinical features, outcome and Cost of Illness (COI) of dengue cases admitted in a tertiary-care government hospital in Chattogram, Bangladesh. Methods & materials: It was a hospital based prospective observational study and was carried out in the Department of Medicine, Chittagong Medical College Hospital. All the consecutive serologically positive (NS1 antigen, IgM, IgG antibodies) dengue cases (age >12 years) admitted in the Department of Medicine of Chittagong Medical College Hospital from 1st August 2019 to 31st July 2020, were enrolled in the study. Severity of each dengue case was determined as per the recent WHO classification (2009) Clinical presentations of the cases were carefully assessed. In-hospital outcomes of the patients in terms of mortality, duration of hospital stay, need for ICU or other support were recorded. The COI questionnaire included three major cost components: direct medical costs (DMC), direct non-xiv medical costs (DNMC), and indirect costs (IC). Data analysis was done on the SPSS 23 version. Results: Out of 425 patients, the maximum number of dengue cases reported were males (76.9%) and belonging to the 21-30 years age group (38.8%). Fever was the main complaint in all the cases followed by headache (78%), myalgia (56%), persistent vomiting (44%). Of the 91.5% Dengue fever cases, 88.2% were classified as Dengue fever without warning signs and 3.3% with warning signs and 8.5% as severe dengue. Thrombocytopenia was present in 53.9% and leukopenia in 42.1% of cases. 3.3% of patients needed ICU admission and the mortality rate was 1.2%. The median total COI was BDT 8703 (IQR: 6240-11795) with median DMC of 3580 (IQR: 2525-4885), DNMC of 2000 (IQR: 1250-3225) and INMC of 2400 (IQR: 1045-4000). Conclusions: Overwhelming number of cases and their varied clinical presentations lead to an increase in hospitalization in this outbreak. Though the outcomes have been mostly favorable, the cost incurred as a result has been immense and has impacted households greatly, since most medical costs in Bangladesh are out-of-pocket expenses.
VL  - 10
IS  - 4
ER  - 

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