Proteomics Based Mongolian Medicine Modified Sugmul-7 Mechanism of Regulating Endocrine Function in Hyperplasia of the Breast

Tong Shan; Tsend Ayushi; Tuul Khalzaibaast; Lian Bao Chen; Chao Lu Meng; Xing An; Ju Hua Gong; Wang Huan

doi:doi:10.11648/j.cmr.20200901.13

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Proteomics Based Mongolian Medicine Modified Sugmul-7 Mechanism of Regulating Endocrine Function in Hyperplasia of the Breast

Tong Shan, Tsend Ayushi, Tuul Khalzaibaast, Lian Bao Chen, Chao Lu Meng, Xing An, Ju Hua Gong, Wang Huan

Published in Clinical Medicine Research (Volume 9, Issue 1)

Received: 14 January 2020 Accepted: 7 February 2020 Published: 14 February 2020

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Abstract

The aim of this study was to explore the mechanism of regulating the endocrine function of hyperplasia breast in rats with modified Mongolian medicine Sugmul-7 by proteomics, and provide experimental basis for its development and clinical application. Ninety female SD rats were randomly divided into normal group, model group, and modified Sugmul-7 low, medium, and high doses in a total of 5 groups. After the start of the experiment, each rat except the normal group was intraperitoneally injected with estradiol 25d and progesterone 6d at a standard dose of 0.3mg / kg for a total of 31 days. Four differential proteins were found through proteomic analysis, namely Ppp3cb, Cacybp, Gstz1Gstz1, and Nmd3 (and satisfying the standard conditions of 1.2 times to 0.8333 times) and found 5 related pathways. Mongolian medicine modified Sugmul-7 estradiol and progesterone-induced hyperplasia of the breast, Ppp3cb, Cacybp, Gstz1Gstz1, Nmd3 and other 4 differential proteins, through cGMP-PKG signal pathway, thyroid hormone signal pathway, estrogen signal pathway gastrointestinal signal related pathways, reproductive system related pathways, etc. regulate endocrine related pathways to treat the disease.

Published in	Clinical Medicine Research (Volume 9, Issue 1)
DOI	10.11648/j.cmr.20200901.13
Page(s)	11-19
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2020. Published by Science Publishing Group

Keywords

Mongolian Medicine Modified Sugmul-7, Hyperplasia of the Breast, Endocrine Function, Proteomics

References

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[6]	Zhao W J, Wang J W, Chang J Z, et al. (2014) Effect of Xianlu Xiaopi capsule on expression of VEGF, bFGF and MVD in breast hyperplasia mice. Shanghai Journal of Traditional Chinese medicine. 48 (3): 74. (in Chinese with English abstract).
[7]	Lin Yi, tang hanjun. Modern Chinese medicine on breast disease [M]. Beijing: people's medical publishing house, 2003, 5: 103.
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APA Style

Tong Shan, Tsend Ayushi, Tuul Khalzaibaast, Lian Bao Chen, Chao Lu Meng, et al. (2020). Proteomics Based Mongolian Medicine Modified Sugmul-7 Mechanism of Regulating Endocrine Function in Hyperplasia of the Breast. Clinical Medicine Research, 9(1), 11-19. https://doi.org/10.11648/j.cmr.20200901.13

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ACS Style

Tong Shan; Tsend Ayushi; Tuul Khalzaibaast; Lian Bao Chen; Chao Lu Meng, et al. Proteomics Based Mongolian Medicine Modified Sugmul-7 Mechanism of Regulating Endocrine Function in Hyperplasia of the Breast. Clin. Med. Res. 2020, 9(1), 11-19. doi: 10.11648/j.cmr.20200901.13

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AMA Style

Tong Shan, Tsend Ayushi, Tuul Khalzaibaast, Lian Bao Chen, Chao Lu Meng, et al. Proteomics Based Mongolian Medicine Modified Sugmul-7 Mechanism of Regulating Endocrine Function in Hyperplasia of the Breast. Clin Med Res. 2020;9(1):11-19. doi: 10.11648/j.cmr.20200901.13

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@article{10.11648/j.cmr.20200901.13,
  author = {Tong Shan and Tsend Ayushi and Tuul Khalzaibaast and Lian Bao Chen and Chao Lu Meng and Xing An and Ju Hua Gong and Wang Huan},
  title = {Proteomics Based Mongolian Medicine Modified Sugmul-7 Mechanism of Regulating Endocrine Function in Hyperplasia of the Breast},
  journal = {Clinical Medicine Research},
  volume = {9},
  number = {1},
  pages = {11-19},
  doi = {10.11648/j.cmr.20200901.13},
  url = {https://doi.org/10.11648/j.cmr.20200901.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.cmr.20200901.13},
  abstract = {The aim of this study was to explore the mechanism of regulating the endocrine function of hyperplasia breast in rats with modified Mongolian medicine Sugmul-7 by proteomics, and provide experimental basis for its development and clinical application. Ninety female SD rats were randomly divided into normal group, model group, and modified Sugmul-7 low, medium, and high doses in a total of 5 groups. After the start of the experiment, each rat except the normal group was intraperitoneally injected with estradiol 25d and progesterone 6d at a standard dose of 0.3mg / kg for a total of 31 days. Four differential proteins were found through proteomic analysis, namely Ppp3cb, Cacybp, Gstz1Gstz1, and Nmd3 (and satisfying the standard conditions of 1.2 times to 0.8333 times) and found 5 related pathways. Mongolian medicine modified Sugmul-7 estradiol and progesterone-induced hyperplasia of the breast, Ppp3cb, Cacybp, Gstz1Gstz1, Nmd3 and other 4 differential proteins, through cGMP-PKG signal pathway, thyroid hormone signal pathway, estrogen signal pathway gastrointestinal signal related pathways, reproductive system related pathways, etc. regulate endocrine related pathways to treat the disease.},
 year = {2020}
}

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TY  - JOUR
T1  - Proteomics Based Mongolian Medicine Modified Sugmul-7 Mechanism of Regulating Endocrine Function in Hyperplasia of the Breast
AU  - Tong Shan
AU  - Tsend Ayushi
AU  - Tuul Khalzaibaast
AU  - Lian Bao Chen
AU  - Chao Lu Meng
AU  - Xing An
AU  - Ju Hua Gong
AU  - Wang Huan
Y1  - 2020/02/14
PY  - 2020
N1  - https://doi.org/10.11648/j.cmr.20200901.13
DO  - 10.11648/j.cmr.20200901.13
T2  - Clinical Medicine Research
JF  - Clinical Medicine Research
JO  - Clinical Medicine Research
SP  - 11
EP  - 19
PB  - Science Publishing Group
SN  - 2326-9057
UR  - https://doi.org/10.11648/j.cmr.20200901.13
AB  - The aim of this study was to explore the mechanism of regulating the endocrine function of hyperplasia breast in rats with modified Mongolian medicine Sugmul-7 by proteomics, and provide experimental basis for its development and clinical application. Ninety female SD rats were randomly divided into normal group, model group, and modified Sugmul-7 low, medium, and high doses in a total of 5 groups. After the start of the experiment, each rat except the normal group was intraperitoneally injected with estradiol 25d and progesterone 6d at a standard dose of 0.3mg / kg for a total of 31 days. Four differential proteins were found through proteomic analysis, namely Ppp3cb, Cacybp, Gstz1Gstz1, and Nmd3 (and satisfying the standard conditions of 1.2 times to 0.8333 times) and found 5 related pathways. Mongolian medicine modified Sugmul-7 estradiol and progesterone-induced hyperplasia of the breast, Ppp3cb, Cacybp, Gstz1Gstz1, Nmd3 and other 4 differential proteins, through cGMP-PKG signal pathway, thyroid hormone signal pathway, estrogen signal pathway gastrointestinal signal related pathways, reproductive system related pathways, etc. regulate endocrine related pathways to treat the disease.
VL  - 9
IS  - 1
ER  -

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Author Information

Tong Shan

Affiliated Hospital of Inner Mongolia University for Nationalities, Tongliao, China
Tsend Ayushi

Mongolian Medical Research Center, International school of Mongolian Traditional Medicine, MNUMS, Ulaanbaatar, Mongolia
Tuul Khalzaibaast

Traditional Medicine Department, Mongolian University Pharmaceutical Sciences, Ulaanbaatar, Mongolia
Lian Bao Chen

Mongolian Medicine and Pharmaceutical School of Inner Mongolia University of Nationalities, Tongliao, China
Chao Lu Meng

Mongolian Medicine and Pharmaceutical School of Inner Mongolia University of Nationalities, Tongliao, China
Xing An

Mongolian Medicine and Pharmaceutical School of Inner Mongolia University of Nationalities, Tongliao, China
Ju Hua Gong

Traditional Chinese Medicine (Mongolian Medicine), Inner Mongolia University for Nationalities, Tongliao, China
Wang Huan

Mongolian Medicine and Pharmaceutical School of Inner Mongolia University for Nationalities, Mongolian Pharmacology Laboratory, Tongliao, China

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Plain Text BibTeX RIS

APA Style

Tong Shan, Tsend Ayushi, Tuul Khalzaibaast, Lian Bao Chen, Chao Lu Meng, et al. (2020). Proteomics Based Mongolian Medicine Modified Sugmul-7 Mechanism of Regulating Endocrine Function in Hyperplasia of the Breast. Clinical Medicine Research, 9(1), 11-19. https://doi.org/10.11648/j.cmr.20200901.13

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ACS Style

Tong Shan; Tsend Ayushi; Tuul Khalzaibaast; Lian Bao Chen; Chao Lu Meng, et al. Proteomics Based Mongolian Medicine Modified Sugmul-7 Mechanism of Regulating Endocrine Function in Hyperplasia of the Breast. Clin. Med. Res. 2020, 9(1), 11-19. doi: 10.11648/j.cmr.20200901.13

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AMA Style

Tong Shan, Tsend Ayushi, Tuul Khalzaibaast, Lian Bao Chen, Chao Lu Meng, et al. Proteomics Based Mongolian Medicine Modified Sugmul-7 Mechanism of Regulating Endocrine Function in Hyperplasia of the Breast. Clin Med Res. 2020;9(1):11-19. doi: 10.11648/j.cmr.20200901.13

Copy | Download

@article{10.11648/j.cmr.20200901.13,
  author = {Tong Shan and Tsend Ayushi and Tuul Khalzaibaast and Lian Bao Chen and Chao Lu Meng and Xing An and Ju Hua Gong and Wang Huan},
  title = {Proteomics Based Mongolian Medicine Modified Sugmul-7 Mechanism of Regulating Endocrine Function in Hyperplasia of the Breast},
  journal = {Clinical Medicine Research},
  volume = {9},
  number = {1},
  pages = {11-19},
  doi = {10.11648/j.cmr.20200901.13},
  url = {https://doi.org/10.11648/j.cmr.20200901.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.cmr.20200901.13},
  abstract = {The aim of this study was to explore the mechanism of regulating the endocrine function of hyperplasia breast in rats with modified Mongolian medicine Sugmul-7 by proteomics, and provide experimental basis for its development and clinical application. Ninety female SD rats were randomly divided into normal group, model group, and modified Sugmul-7 low, medium, and high doses in a total of 5 groups. After the start of the experiment, each rat except the normal group was intraperitoneally injected with estradiol 25d and progesterone 6d at a standard dose of 0.3mg / kg for a total of 31 days. Four differential proteins were found through proteomic analysis, namely Ppp3cb, Cacybp, Gstz1Gstz1, and Nmd3 (and satisfying the standard conditions of 1.2 times to 0.8333 times) and found 5 related pathways. Mongolian medicine modified Sugmul-7 estradiol and progesterone-induced hyperplasia of the breast, Ppp3cb, Cacybp, Gstz1Gstz1, Nmd3 and other 4 differential proteins, through cGMP-PKG signal pathway, thyroid hormone signal pathway, estrogen signal pathway gastrointestinal signal related pathways, reproductive system related pathways, etc. regulate endocrine related pathways to treat the disease.},
 year = {2020}
}

Copy | Download

TY  - JOUR
T1  - Proteomics Based Mongolian Medicine Modified Sugmul-7 Mechanism of Regulating Endocrine Function in Hyperplasia of the Breast
AU  - Tong Shan
AU  - Tsend Ayushi
AU  - Tuul Khalzaibaast
AU  - Lian Bao Chen
AU  - Chao Lu Meng
AU  - Xing An
AU  - Ju Hua Gong
AU  - Wang Huan
Y1  - 2020/02/14
PY  - 2020
N1  - https://doi.org/10.11648/j.cmr.20200901.13
DO  - 10.11648/j.cmr.20200901.13
T2  - Clinical Medicine Research
JF  - Clinical Medicine Research
JO  - Clinical Medicine Research
SP  - 11
EP  - 19
PB  - Science Publishing Group
SN  - 2326-9057
UR  - https://doi.org/10.11648/j.cmr.20200901.13
AB  - The aim of this study was to explore the mechanism of regulating the endocrine function of hyperplasia breast in rats with modified Mongolian medicine Sugmul-7 by proteomics, and provide experimental basis for its development and clinical application. Ninety female SD rats were randomly divided into normal group, model group, and modified Sugmul-7 low, medium, and high doses in a total of 5 groups. After the start of the experiment, each rat except the normal group was intraperitoneally injected with estradiol 25d and progesterone 6d at a standard dose of 0.3mg / kg for a total of 31 days. Four differential proteins were found through proteomic analysis, namely Ppp3cb, Cacybp, Gstz1Gstz1, and Nmd3 (and satisfying the standard conditions of 1.2 times to 0.8333 times) and found 5 related pathways. Mongolian medicine modified Sugmul-7 estradiol and progesterone-induced hyperplasia of the breast, Ppp3cb, Cacybp, Gstz1Gstz1, Nmd3 and other 4 differential proteins, through cGMP-PKG signal pathway, thyroid hormone signal pathway, estrogen signal pathway gastrointestinal signal related pathways, reproductive system related pathways, etc. regulate endocrine related pathways to treat the disease.
VL  - 9
IS  - 1
ER  -

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