Gastric Bypass Surgery Regulates Glucose Homeostasis Through the Hypothalamus

Huangna Quan; Xue-jun Yang

doi:doi:10.11648/j.cmr.20190802.11

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Gastric Bypass Surgery Regulates Glucose Homeostasis Through the Hypothalamus

Huangna Quan, Xue-jun Yang

Published in Clinical Medicine Research (Volume 8, Issue 2)

Received: 14 April 2019 Accepted: 28 May 2019 Published: 12 June 2019

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Abstract

To explore the role of blood glucose regulation in gastric bypass surgery is a hot point in the treatment of diabetes in recent years. Current evidence is very clear that the gastric bypass surgery is one of the most promising therapy to cure type 2 diabetes. However, the mechanisms are not yet understood. Studying the mechanism of surgical treatment can not only understand the pathogenesis of diabetes, but also have important scientific and practical significance for clinically and safely carrying out this therapy. As is known to all, the body's energy metabolism and glucose homeostasis are regulated by the hypothalamus. Thus, we summarize the process mechanism of central regulation of glucose homeostasis in post-surgery and find that the hypothalamus after gastric bypass surgery showed enhanced expression of peripheral signal receptors, enhancement of leptin signal and insulin signal, and expression changes of certain related genes, then issued neuroendocrine signals to control peripheral insulin sensitivity and glucose metabolism. Then, we prove that the improvement of peripheral metabolic status is caused by the decisive role of central regulation in post-surgery. These funding provide scientific basis to improve the understanding of the neuroendocrine mechanism of diabetes and the development of clinical implication of gastric bypass surgery.

Published in	Clinical Medicine Research (Volume 8, Issue 2)
DOI	10.11648/j.cmr.20190802.11
Page(s)	32-38
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2019. Published by Science Publishing Group

Keywords

Gastric Bypass Surgery, Hypothalamus, Glucose Homeostasis, Neuroendocrine, Diabetes

References

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APA Style

Huangna Quan, Xue-jun Yang. (2019). Gastric Bypass Surgery Regulates Glucose Homeostasis Through the Hypothalamus. Clinical Medicine Research, 8(2), 32-38. https://doi.org/10.11648/j.cmr.20190802.11

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Huangna Quan; Xue-jun Yang. Gastric Bypass Surgery Regulates Glucose Homeostasis Through the Hypothalamus. Clin. Med. Res. 2019, 8(2), 32-38. doi: 10.11648/j.cmr.20190802.11

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AMA Style

Huangna Quan, Xue-jun Yang. Gastric Bypass Surgery Regulates Glucose Homeostasis Through the Hypothalamus. Clin Med Res. 2019;8(2):32-38. doi: 10.11648/j.cmr.20190802.11

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@article{10.11648/j.cmr.20190802.11,
  author = {Huangna Quan and Xue-jun Yang},
  title = {Gastric Bypass Surgery Regulates Glucose Homeostasis Through the Hypothalamus},
  journal = {Clinical Medicine Research},
  volume = {8},
  number = {2},
  pages = {32-38},
  doi = {10.11648/j.cmr.20190802.11},
  url = {https://doi.org/10.11648/j.cmr.20190802.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.cmr.20190802.11},
  abstract = {To explore the role of blood glucose regulation in gastric bypass surgery is a hot point in the treatment of diabetes in recent years. Current evidence is very clear that the gastric bypass surgery is one of the most promising therapy to cure type 2 diabetes. However, the mechanisms are not yet understood. Studying the mechanism of surgical treatment can not only understand the pathogenesis of diabetes, but also have important scientific and practical significance for clinically and safely carrying out this therapy. As is known to all, the body's energy metabolism and glucose homeostasis are regulated by the hypothalamus. Thus, we summarize the process mechanism of central regulation of glucose homeostasis in post-surgery and find that the hypothalamus after gastric bypass surgery showed enhanced expression of peripheral signal receptors, enhancement of leptin signal and insulin signal, and expression changes of certain related genes, then issued neuroendocrine signals to control peripheral insulin sensitivity and glucose metabolism. Then, we prove that the improvement of peripheral metabolic status is caused by the decisive role of central regulation in post-surgery. These funding provide scientific basis to improve the understanding of the neuroendocrine mechanism of diabetes and the development of clinical implication of gastric bypass surgery.},
 year = {2019}
}

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TY  - JOUR
T1  - Gastric Bypass Surgery Regulates Glucose Homeostasis Through the Hypothalamus
AU  - Huangna Quan
AU  - Xue-jun Yang
Y1  - 2019/06/12
PY  - 2019
N1  - https://doi.org/10.11648/j.cmr.20190802.11
DO  - 10.11648/j.cmr.20190802.11
T2  - Clinical Medicine Research
JF  - Clinical Medicine Research
JO  - Clinical Medicine Research
SP  - 32
EP  - 38
PB  - Science Publishing Group
SN  - 2326-9057
UR  - https://doi.org/10.11648/j.cmr.20190802.11
AB  - To explore the role of blood glucose regulation in gastric bypass surgery is a hot point in the treatment of diabetes in recent years. Current evidence is very clear that the gastric bypass surgery is one of the most promising therapy to cure type 2 diabetes. However, the mechanisms are not yet understood. Studying the mechanism of surgical treatment can not only understand the pathogenesis of diabetes, but also have important scientific and practical significance for clinically and safely carrying out this therapy. As is known to all, the body's energy metabolism and glucose homeostasis are regulated by the hypothalamus. Thus, we summarize the process mechanism of central regulation of glucose homeostasis in post-surgery and find that the hypothalamus after gastric bypass surgery showed enhanced expression of peripheral signal receptors, enhancement of leptin signal and insulin signal, and expression changes of certain related genes, then issued neuroendocrine signals to control peripheral insulin sensitivity and glucose metabolism. Then, we prove that the improvement of peripheral metabolic status is caused by the decisive role of central regulation in post-surgery. These funding provide scientific basis to improve the understanding of the neuroendocrine mechanism of diabetes and the development of clinical implication of gastric bypass surgery.
VL  - 8
IS  - 2
ER  -

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Author Information

Huangna Quan

Department of Endocrinology, Central South University Xiangya School of Medicine Affiliated Haikou Hospital, Haikou City, China
Xue-jun Yang

Department of Endocrinology, Central South University Xiangya School of Medicine Affiliated Haikou Hospital, Haikou City, China

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Plain Text BibTeX RIS

APA Style

Huangna Quan, Xue-jun Yang. (2019). Gastric Bypass Surgery Regulates Glucose Homeostasis Through the Hypothalamus. Clinical Medicine Research, 8(2), 32-38. https://doi.org/10.11648/j.cmr.20190802.11

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ACS Style

Huangna Quan; Xue-jun Yang. Gastric Bypass Surgery Regulates Glucose Homeostasis Through the Hypothalamus. Clin. Med. Res. 2019, 8(2), 32-38. doi: 10.11648/j.cmr.20190802.11

Copy | Download

AMA Style

Huangna Quan, Xue-jun Yang. Gastric Bypass Surgery Regulates Glucose Homeostasis Through the Hypothalamus. Clin Med Res. 2019;8(2):32-38. doi: 10.11648/j.cmr.20190802.11

Copy | Download

@article{10.11648/j.cmr.20190802.11,
  author = {Huangna Quan and Xue-jun Yang},
  title = {Gastric Bypass Surgery Regulates Glucose Homeostasis Through the Hypothalamus},
  journal = {Clinical Medicine Research},
  volume = {8},
  number = {2},
  pages = {32-38},
  doi = {10.11648/j.cmr.20190802.11},
  url = {https://doi.org/10.11648/j.cmr.20190802.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.cmr.20190802.11},
  abstract = {To explore the role of blood glucose regulation in gastric bypass surgery is a hot point in the treatment of diabetes in recent years. Current evidence is very clear that the gastric bypass surgery is one of the most promising therapy to cure type 2 diabetes. However, the mechanisms are not yet understood. Studying the mechanism of surgical treatment can not only understand the pathogenesis of diabetes, but also have important scientific and practical significance for clinically and safely carrying out this therapy. As is known to all, the body's energy metabolism and glucose homeostasis are regulated by the hypothalamus. Thus, we summarize the process mechanism of central regulation of glucose homeostasis in post-surgery and find that the hypothalamus after gastric bypass surgery showed enhanced expression of peripheral signal receptors, enhancement of leptin signal and insulin signal, and expression changes of certain related genes, then issued neuroendocrine signals to control peripheral insulin sensitivity and glucose metabolism. Then, we prove that the improvement of peripheral metabolic status is caused by the decisive role of central regulation in post-surgery. These funding provide scientific basis to improve the understanding of the neuroendocrine mechanism of diabetes and the development of clinical implication of gastric bypass surgery.},
 year = {2019}
}

Copy | Download

TY  - JOUR
T1  - Gastric Bypass Surgery Regulates Glucose Homeostasis Through the Hypothalamus
AU  - Huangna Quan
AU  - Xue-jun Yang
Y1  - 2019/06/12
PY  - 2019
N1  - https://doi.org/10.11648/j.cmr.20190802.11
DO  - 10.11648/j.cmr.20190802.11
T2  - Clinical Medicine Research
JF  - Clinical Medicine Research
JO  - Clinical Medicine Research
SP  - 32
EP  - 38
PB  - Science Publishing Group
SN  - 2326-9057
UR  - https://doi.org/10.11648/j.cmr.20190802.11
AB  - To explore the role of blood glucose regulation in gastric bypass surgery is a hot point in the treatment of diabetes in recent years. Current evidence is very clear that the gastric bypass surgery is one of the most promising therapy to cure type 2 diabetes. However, the mechanisms are not yet understood. Studying the mechanism of surgical treatment can not only understand the pathogenesis of diabetes, but also have important scientific and practical significance for clinically and safely carrying out this therapy. As is known to all, the body's energy metabolism and glucose homeostasis are regulated by the hypothalamus. Thus, we summarize the process mechanism of central regulation of glucose homeostasis in post-surgery and find that the hypothalamus after gastric bypass surgery showed enhanced expression of peripheral signal receptors, enhancement of leptin signal and insulin signal, and expression changes of certain related genes, then issued neuroendocrine signals to control peripheral insulin sensitivity and glucose metabolism. Then, we prove that the improvement of peripheral metabolic status is caused by the decisive role of central regulation in post-surgery. These funding provide scientific basis to improve the understanding of the neuroendocrine mechanism of diabetes and the development of clinical implication of gastric bypass surgery.
VL  - 8
IS  - 2
ER  -

Copy | Download