The Influence of Abnormal Mother to Infant Thyroid Function, Early Intervention Treatment on the Compensation for Mental Retardation

Zhao Ying; Liu Xiaoqing; Su Yang; Zheng Ying; Niu Guizhen

doi:doi:10.11648/j.cmr.20180704.12

| Peer-Reviewed

The Influence of Abnormal Mother to Infant Thyroid Function, Early Intervention Treatment on the Compensation for Mental Retardation

Zhao Ying, Liu Xiaoqing, Su Yang, Zheng Ying, Niu Guizhen

Published in Clinical Medicine Research (Volume 7, Issue 4)

Received: 9 July 2018 Accepted: 9 August 2018 Published: 11 October 2018

Views: Downloads:

Download PDF

Share This Article

Twitter
Linked In
Facebook

Abstract

Objective: To observe the hyperthyroidism and hypothyroidism patients with pregnancy after production, the baby’s thyroid function changes, the baby's mental abnormality, compensation for the children with intellectual disabilities and early intervention after treatment. Methods: In this study, 151 pregnant women with abnormal thyroid function from Department of Endocrinology in Jilin Central Hospital between 2010-2016, these women in the G12 and G24 were measured FT3, FT4, TSH, TPO, TG-ab, the babies at birth, 6 months, 12 months, examine their thyroid function, exercise and intelligence score respectively. Results: Hyperthyroidism group and hypothyroidism group of pregnant women after intervention treatment of G12 and G24, thyroid function tends to normal, there were no significant differences in FT3, FT4 and TSH levels. TSH was significantly increased in the patients with hyperthyroidism group at birth, compared with the other two groups, P < 0.05, the difference was statistically significant. Comparison of the nerve intelligence development and motor scores of the pregnant women in each group MDI and PDI, the levels of MDI and PDI in the hyperthyroidism group were decreased, but the late rise was obvious, there was no significant difference between the groups. There was no significant difference in the development of thyroid and nerve intelligence and motor scores after early intervention in the healthy control group. Conclusion: The abnormal thyroid function of pregnant women can affect the thyroid function of offspring, so that the intelligence development of offspring is affected. Adverse pregnancy was significantly increased, timely intervention treatment of pregnant women with abnormal thyroid function and adjustment of sub generation, the intelligence score and the absolute value of the motor score can be increased, it shows compensative effect on mental retardation in their offspring.

Published in	Clinical Medicine Research (Volume 7, Issue 4)
DOI	10.11648/j.cmr.20180704.12
Page(s)	92-96
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2018. Published by Science Publishing Group

Keywords

Thyroid Function, Mental Retardation, Intervention Therapy

References

[1]	Tiemeier H, Peeters RP. Association of maternal thyroid function during early pregnancy with offspring IQ and brain morphology in childhood: a population-based prospective cohort study. Lancet Diabetes Endocrinol. 2016 Jan;4(1):35-43. doi: 10.1016/S2213-8587(15)00327-7.
[2]	Levie D, Korevaar TIM, Bath SC, Dalmau-Bueno A, Murcia M, Espada M, Dineva M, Ibarluzea JM, Sunyer J, Tiemeier H, Rebagliato M, Rayman MP, Peeters RP, Guxens M. Thyroid Function in Early Pregnancy, Child IQ, and Autistic Traits: a Meta-analysis of Individual-participant Data. J Clin Endocrinol Metab. 2018 May 10. doi: 10.1210/jc.2018-00224.
[3]	Derakhshan A, Korevaar TIM, Taylor PN, Levie D, Guxens M, Jaddoe VWV, Nelson SM, Tiemeier H, Peeters RP. The Association of Maternal Thyroid Autoimmunity During Pregnancy with Child IQ. J Clin Endocrinol Metab. 2018 Jul 17. doi: 10.1210/jc.2018-00743.
[4]	De Leo S, Pearce EN. Autoimmune thyroid disease during pregnancy. Lancet Diabetes Endocrinol. 2018 Jul;6(7):575-586. doi: 10.1016/S2213-8587(17)30402-3.
[5]	Korevaar TIM, Tiemeier H, Peeters RP. Clinical associations of maternal thyroid function with foetal brain development: Epidemiological interpretation and overview of available evidence. Clin Endocrinol (Oxf). 2018 Apr 24. doi: 10.1111/cen.13724.
[6]	Mannisto T. Mendola P. Grewal J. et al. Thyroid diseases and adverse pregnancy outcomes in a contemporary US cohort [J]. J Clin Endcrinol Metab, 2013, 98(7：2725-2733).
[7]	Andersen SL, Olsen J, Wu CS, et al. Spontaneous abortion, stllbirth and hyperthyroidism: a danish population-based study [J]. Eur Thyroid J, 2014, 3(3):164-172.
[8]	Millar LK, Wing DA, Leung AS, et al, Low birth weight and preeclampsia in pregnancies complicated by hyperthyroidism [J]. Obstet Gynecol, 1994, 84(6):946-949.
[9]	Gartner R. Thyroid diseases in pregnancy. Lurr Opin Obstet Gynecol, 2009, 67:178-182.
[10]	Debieve F, Duliere S, Bemard P, et, al. To treat or not to treat euthyroid autoimmmmune disorder during pregnancy? Gynecol Obestet Invest, 2009, 67:178-182.
[11]	Oken E, BRAVERMAN lE, Plate D, et al. Neonatal Thyroxine, maternal thyroid function, and chijd cognition. J Clin Endocrinol Metab, 2009, 94:497-503.
[12]	Rovelli R, Vigone MC, Giovanettoni C, et al. Newborn of mothers affected autoimmune thyroiditis: the importance of thyroid function monitoring in the first months of life. Ital J Pediatr, 2010, 36: 24.
[13]	Du Peiyi, kitta Zhong Lili, etc. Thyroid autoantibody positive women intervention effect on infants thyroid function during pregnancy. The endocrine metabolism, 2010, 26:931-935.

Cite This Article

Plain Text BibTeX RIS

APA Style

Zhao Ying, Liu Xiaoqing, Su Yang, Zheng Ying, Niu Guizhen. (2018). The Influence of Abnormal Mother to Infant Thyroid Function, Early Intervention Treatment on the Compensation for Mental Retardation. Clinical Medicine Research, 7(4), 92-96. https://doi.org/10.11648/j.cmr.20180704.12

Copy | Download

ACS Style

Zhao Ying; Liu Xiaoqing; Su Yang; Zheng Ying; Niu Guizhen. The Influence of Abnormal Mother to Infant Thyroid Function, Early Intervention Treatment on the Compensation for Mental Retardation. Clin. Med. Res. 2018, 7(4), 92-96. doi: 10.11648/j.cmr.20180704.12

Copy | Download

AMA Style

Zhao Ying, Liu Xiaoqing, Su Yang, Zheng Ying, Niu Guizhen. The Influence of Abnormal Mother to Infant Thyroid Function, Early Intervention Treatment on the Compensation for Mental Retardation. Clin Med Res. 2018;7(4):92-96. doi: 10.11648/j.cmr.20180704.12

Copy | Download

@article{10.11648/j.cmr.20180704.12,
  author = {Zhao Ying and Liu Xiaoqing and Su Yang and Zheng Ying and Niu Guizhen},
  title = {The Influence of Abnormal Mother to Infant Thyroid Function, Early Intervention Treatment on the Compensation for Mental Retardation},
  journal = {Clinical Medicine Research},
  volume = {7},
  number = {4},
  pages = {92-96},
  doi = {10.11648/j.cmr.20180704.12},
  url = {https://doi.org/10.11648/j.cmr.20180704.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.cmr.20180704.12},
  abstract = {Objective: To observe the hyperthyroidism and hypothyroidism patients with pregnancy after production, the baby’s thyroid function changes, the baby's mental abnormality, compensation for the children with intellectual disabilities and early intervention after treatment. Methods: In this study, 151 pregnant women with abnormal thyroid function from Department of Endocrinology in Jilin Central Hospital between 2010-2016, these women in the G12 and G24 were measured FT3, FT4, TSH, TPO, TG-ab, the babies at birth, 6 months, 12 months, examine their thyroid function, exercise and intelligence score respectively. Results: Hyperthyroidism group and hypothyroidism group of pregnant women after intervention treatment of G12 and G24, thyroid function tends to normal, there were no significant differences in FT3, FT4 and TSH levels. TSH was significantly increased in the patients with hyperthyroidism group at birth, compared with the other two groups, P < 0.05, the difference was statistically significant. Comparison of the nerve intelligence development and motor scores of the pregnant women in each group MDI and PDI, the levels of MDI and PDI in the hyperthyroidism group were decreased, but the late rise was obvious, there was no significant difference between the groups. There was no significant difference in the development of thyroid and nerve intelligence and motor scores after early intervention in the healthy control group. Conclusion: The abnormal thyroid function of pregnant women can affect the thyroid function of offspring, so that the intelligence development of offspring is affected. Adverse pregnancy was significantly increased, timely intervention treatment of pregnant women with abnormal thyroid function and adjustment of sub generation, the intelligence score and the absolute value of the motor score can be increased, it shows compensative effect on mental retardation in their offspring.},
 year = {2018}
}

Copy | Download

TY  - JOUR
T1  - The Influence of Abnormal Mother to Infant Thyroid Function, Early Intervention Treatment on the Compensation for Mental Retardation
AU  - Zhao Ying
AU  - Liu Xiaoqing
AU  - Su Yang
AU  - Zheng Ying
AU  - Niu Guizhen
Y1  - 2018/10/11
PY  - 2018
N1  - https://doi.org/10.11648/j.cmr.20180704.12
DO  - 10.11648/j.cmr.20180704.12
T2  - Clinical Medicine Research
JF  - Clinical Medicine Research
JO  - Clinical Medicine Research
SP  - 92
EP  - 96
PB  - Science Publishing Group
SN  - 2326-9057
UR  - https://doi.org/10.11648/j.cmr.20180704.12
AB  - Objective: To observe the hyperthyroidism and hypothyroidism patients with pregnancy after production, the baby’s thyroid function changes, the baby's mental abnormality, compensation for the children with intellectual disabilities and early intervention after treatment. Methods: In this study, 151 pregnant women with abnormal thyroid function from Department of Endocrinology in Jilin Central Hospital between 2010-2016, these women in the G12 and G24 were measured FT3, FT4, TSH, TPO, TG-ab, the babies at birth, 6 months, 12 months, examine their thyroid function, exercise and intelligence score respectively. Results: Hyperthyroidism group and hypothyroidism group of pregnant women after intervention treatment of G12 and G24, thyroid function tends to normal, there were no significant differences in FT3, FT4 and TSH levels. TSH was significantly increased in the patients with hyperthyroidism group at birth, compared with the other two groups, P < 0.05, the difference was statistically significant. Comparison of the nerve intelligence development and motor scores of the pregnant women in each group MDI and PDI, the levels of MDI and PDI in the hyperthyroidism group were decreased, but the late rise was obvious, there was no significant difference between the groups. There was no significant difference in the development of thyroid and nerve intelligence and motor scores after early intervention in the healthy control group. Conclusion: The abnormal thyroid function of pregnant women can affect the thyroid function of offspring, so that the intelligence development of offspring is affected. Adverse pregnancy was significantly increased, timely intervention treatment of pregnant women with abnormal thyroid function and adjustment of sub generation, the intelligence score and the absolute value of the motor score can be increased, it shows compensative effect on mental retardation in their offspring.
VL  - 7
IS  - 4
ER  -

Copy | Download

Author Information

Zhao Ying

Department of Endocrinology, Jilin Central Hospital, Jilin, China
Liu Xiaoqing

Department of Endocrinology, Jilin Central Hospital, Jilin, China
Su Yang

Department of Endocrinology, Jilin Central Hospital, Jilin, China
Zheng Ying

Department of Endocrinology, Jilin Central Hospital, Jilin, China
Niu Guizhen

Jilin NCMS Management Center, Jilin, China

Download PDF

Sections

Plain Text BibTeX RIS

APA Style

Zhao Ying, Liu Xiaoqing, Su Yang, Zheng Ying, Niu Guizhen. (2018). The Influence of Abnormal Mother to Infant Thyroid Function, Early Intervention Treatment on the Compensation for Mental Retardation. Clinical Medicine Research, 7(4), 92-96. https://doi.org/10.11648/j.cmr.20180704.12

Copy | Download

ACS Style

Zhao Ying; Liu Xiaoqing; Su Yang; Zheng Ying; Niu Guizhen. The Influence of Abnormal Mother to Infant Thyroid Function, Early Intervention Treatment on the Compensation for Mental Retardation. Clin. Med. Res. 2018, 7(4), 92-96. doi: 10.11648/j.cmr.20180704.12

Copy | Download

AMA Style

Zhao Ying, Liu Xiaoqing, Su Yang, Zheng Ying, Niu Guizhen. The Influence of Abnormal Mother to Infant Thyroid Function, Early Intervention Treatment on the Compensation for Mental Retardation. Clin Med Res. 2018;7(4):92-96. doi: 10.11648/j.cmr.20180704.12

Copy | Download

@article{10.11648/j.cmr.20180704.12,
  author = {Zhao Ying and Liu Xiaoqing and Su Yang and Zheng Ying and Niu Guizhen},
  title = {The Influence of Abnormal Mother to Infant Thyroid Function, Early Intervention Treatment on the Compensation for Mental Retardation},
  journal = {Clinical Medicine Research},
  volume = {7},
  number = {4},
  pages = {92-96},
  doi = {10.11648/j.cmr.20180704.12},
  url = {https://doi.org/10.11648/j.cmr.20180704.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.cmr.20180704.12},
  abstract = {Objective: To observe the hyperthyroidism and hypothyroidism patients with pregnancy after production, the baby’s thyroid function changes, the baby's mental abnormality, compensation for the children with intellectual disabilities and early intervention after treatment. Methods: In this study, 151 pregnant women with abnormal thyroid function from Department of Endocrinology in Jilin Central Hospital between 2010-2016, these women in the G12 and G24 were measured FT3, FT4, TSH, TPO, TG-ab, the babies at birth, 6 months, 12 months, examine their thyroid function, exercise and intelligence score respectively. Results: Hyperthyroidism group and hypothyroidism group of pregnant women after intervention treatment of G12 and G24, thyroid function tends to normal, there were no significant differences in FT3, FT4 and TSH levels. TSH was significantly increased in the patients with hyperthyroidism group at birth, compared with the other two groups, P < 0.05, the difference was statistically significant. Comparison of the nerve intelligence development and motor scores of the pregnant women in each group MDI and PDI, the levels of MDI and PDI in the hyperthyroidism group were decreased, but the late rise was obvious, there was no significant difference between the groups. There was no significant difference in the development of thyroid and nerve intelligence and motor scores after early intervention in the healthy control group. Conclusion: The abnormal thyroid function of pregnant women can affect the thyroid function of offspring, so that the intelligence development of offspring is affected. Adverse pregnancy was significantly increased, timely intervention treatment of pregnant women with abnormal thyroid function and adjustment of sub generation, the intelligence score and the absolute value of the motor score can be increased, it shows compensative effect on mental retardation in their offspring.},
 year = {2018}
}

Copy | Download

TY  - JOUR
T1  - The Influence of Abnormal Mother to Infant Thyroid Function, Early Intervention Treatment on the Compensation for Mental Retardation
AU  - Zhao Ying
AU  - Liu Xiaoqing
AU  - Su Yang
AU  - Zheng Ying
AU  - Niu Guizhen
Y1  - 2018/10/11
PY  - 2018
N1  - https://doi.org/10.11648/j.cmr.20180704.12
DO  - 10.11648/j.cmr.20180704.12
T2  - Clinical Medicine Research
JF  - Clinical Medicine Research
JO  - Clinical Medicine Research
SP  - 92
EP  - 96
PB  - Science Publishing Group
SN  - 2326-9057
UR  - https://doi.org/10.11648/j.cmr.20180704.12
AB  - Objective: To observe the hyperthyroidism and hypothyroidism patients with pregnancy after production, the baby’s thyroid function changes, the baby's mental abnormality, compensation for the children with intellectual disabilities and early intervention after treatment. Methods: In this study, 151 pregnant women with abnormal thyroid function from Department of Endocrinology in Jilin Central Hospital between 2010-2016, these women in the G12 and G24 were measured FT3, FT4, TSH, TPO, TG-ab, the babies at birth, 6 months, 12 months, examine their thyroid function, exercise and intelligence score respectively. Results: Hyperthyroidism group and hypothyroidism group of pregnant women after intervention treatment of G12 and G24, thyroid function tends to normal, there were no significant differences in FT3, FT4 and TSH levels. TSH was significantly increased in the patients with hyperthyroidism group at birth, compared with the other two groups, P < 0.05, the difference was statistically significant. Comparison of the nerve intelligence development and motor scores of the pregnant women in each group MDI and PDI, the levels of MDI and PDI in the hyperthyroidism group were decreased, but the late rise was obvious, there was no significant difference between the groups. There was no significant difference in the development of thyroid and nerve intelligence and motor scores after early intervention in the healthy control group. Conclusion: The abnormal thyroid function of pregnant women can affect the thyroid function of offspring, so that the intelligence development of offspring is affected. Adverse pregnancy was significantly increased, timely intervention treatment of pregnant women with abnormal thyroid function and adjustment of sub generation, the intelligence score and the absolute value of the motor score can be increased, it shows compensative effect on mental retardation in their offspring.
VL  - 7
IS  - 4
ER  -

Copy | Download