Hyperuricemia and Its Correlation with Target Organ Damage and Electrocardiographic Changes in Newly Diagnosed Adult Nigerian Hypertensive Patients

Abidemi Jude Fasae; Olusegun Adesola Busari; Rotimi Oluyombo; Musa Yusuf; Oladipo George Opadijo; Ayodele Babatunde Omotoso

doi:doi:10.11648/j.cmr.20180701.11

Hyperuricemia and Its Correlation with Target Organ Damage and Electrocardiographic Changes in Newly Diagnosed Adult Nigerian Hypertensive Patients

Abidemi Jude Fasae, Olusegun Adesola Busari, Rotimi Oluyombo, Musa Yusuf, Oladipo George Opadijo, Ayodele Babatunde Omotoso

Published in Clinical Medicine Research (Volume 7, Issue 1)

Received: 10 March 2017 Accepted: 10 April 2017 Published: 26 January 2018

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Abstract

The objective of the study was to determine the prevalence of Hyperuricemia and evaluate its correlation with target organ damage and electrocardiographic changes in newly diagnosed adult Nigerian hypertensive patients. It was a cross sectional study done at the University of Ilorin Teaching Hospital, Ilorin, Nigeria. 150 untreated newly diagnosed hypertensive patients 18 years and above and 115 age and sex-matched normotensive individuals were recruited into the study. Data obtained was analyzed using Epi-Info version 6.04 and Statistical Package for Social Sciences (SPSS) version 14 computer software packages. The prevalence of Hyperuricemia was 36.7% and 17.4% in hypertensive patients and normotensive controls respectively. Mean serum UA in hypertensive patients and normotensive controls was 0.4±0.1mmol/l and 0.3±0.1mmol/l respectively (p<0.0001). There was an association between Hyperuricemia and left ventricular hypertrophy (x²=23.97, p<0.0001). The study showed that Hyperuricemia is prevalent in adult Nigerians with newly diagnosed hypertension. Hyperuricemia was associated with left ventricular hypertrophy which is common target organ damage and confers an increased risk of cardiovascular events in systemic hypertension.

Published in	Clinical Medicine Research (Volume 7, Issue 1)
DOI	10.11648/j.cmr.20180701.11
Page(s)	1-7
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2018. Published by Science Publishing Group

Keywords

Hyperuricemia, Target Organ Damage, Electrocardiographic Changes, Hypertensive Nigerians

References

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APA Style

Abidemi Jude Fasae, Olusegun Adesola Busari, Rotimi Oluyombo, Musa Yusuf, Oladipo George Opadijo, et al. (2018). Hyperuricemia and Its Correlation with Target Organ Damage and Electrocardiographic Changes in Newly Diagnosed Adult Nigerian Hypertensive Patients. Clinical Medicine Research, 7(1), 1-7. https://doi.org/10.11648/j.cmr.20180701.11

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ACS Style

Abidemi Jude Fasae; Olusegun Adesola Busari; Rotimi Oluyombo; Musa Yusuf; Oladipo George Opadijo, et al. Hyperuricemia and Its Correlation with Target Organ Damage and Electrocardiographic Changes in Newly Diagnosed Adult Nigerian Hypertensive Patients. Clin. Med. Res. 2018, 7(1), 1-7. doi: 10.11648/j.cmr.20180701.11

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AMA Style

Abidemi Jude Fasae, Olusegun Adesola Busari, Rotimi Oluyombo, Musa Yusuf, Oladipo George Opadijo, et al. Hyperuricemia and Its Correlation with Target Organ Damage and Electrocardiographic Changes in Newly Diagnosed Adult Nigerian Hypertensive Patients. Clin Med Res. 2018;7(1):1-7. doi: 10.11648/j.cmr.20180701.11

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@article{10.11648/j.cmr.20180701.11,
  author = {Abidemi Jude Fasae and Olusegun Adesola Busari and Rotimi Oluyombo and Musa Yusuf and Oladipo George Opadijo and Ayodele Babatunde Omotoso},
  title = {Hyperuricemia and Its Correlation with Target Organ Damage and Electrocardiographic Changes in Newly Diagnosed Adult Nigerian Hypertensive Patients},
  journal = {Clinical Medicine Research},
  volume = {7},
  number = {1},
  pages = {1-7},
  doi = {10.11648/j.cmr.20180701.11},
  url = {https://doi.org/10.11648/j.cmr.20180701.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.cmr.20180701.11},
  abstract = {The objective of the study was to determine the prevalence of Hyperuricemia and evaluate its correlation with target organ damage and electrocardiographic changes in newly diagnosed adult Nigerian hypertensive patients. It was a cross sectional study done at the University of Ilorin Teaching Hospital, Ilorin, Nigeria. 150 untreated newly diagnosed hypertensive patients 18 years and above and 115 age and sex-matched normotensive individuals were recruited into the study. Data obtained was analyzed using Epi-Info version 6.04 and Statistical Package for Social Sciences (SPSS) version 14 computer software packages. The prevalence of Hyperuricemia was 36.7% and 17.4% in hypertensive patients and normotensive controls respectively. Mean serum UA in hypertensive patients and normotensive controls was 0.4±0.1mmol/l and 0.3±0.1mmol/l respectively (p2=23.97, p<0.0001). The study showed that Hyperuricemia is prevalent in adult Nigerians with newly diagnosed hypertension. Hyperuricemia was associated with left ventricular hypertrophy which is common target organ damage and confers an increased risk of cardiovascular events in systemic hypertension.},
 year = {2018}
}

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TY  - JOUR
T1  - Hyperuricemia and Its Correlation with Target Organ Damage and Electrocardiographic Changes in Newly Diagnosed Adult Nigerian Hypertensive Patients
AU  - Abidemi Jude Fasae
AU  - Olusegun Adesola Busari
AU  - Rotimi Oluyombo
AU  - Musa Yusuf
AU  - Oladipo George Opadijo
AU  - Ayodele Babatunde Omotoso
Y1  - 2018/01/26
PY  - 2018
N1  - https://doi.org/10.11648/j.cmr.20180701.11
DO  - 10.11648/j.cmr.20180701.11
T2  - Clinical Medicine Research
JF  - Clinical Medicine Research
JO  - Clinical Medicine Research
SP  - 1
EP  - 7
PB  - Science Publishing Group
SN  - 2326-9057
UR  - https://doi.org/10.11648/j.cmr.20180701.11
AB  - The objective of the study was to determine the prevalence of Hyperuricemia and evaluate its correlation with target organ damage and electrocardiographic changes in newly diagnosed adult Nigerian hypertensive patients. It was a cross sectional study done at the University of Ilorin Teaching Hospital, Ilorin, Nigeria. 150 untreated newly diagnosed hypertensive patients 18 years and above and 115 age and sex-matched normotensive individuals were recruited into the study. Data obtained was analyzed using Epi-Info version 6.04 and Statistical Package for Social Sciences (SPSS) version 14 computer software packages. The prevalence of Hyperuricemia was 36.7% and 17.4% in hypertensive patients and normotensive controls respectively. Mean serum UA in hypertensive patients and normotensive controls was 0.4±0.1mmol/l and 0.3±0.1mmol/l respectively (p2=23.97, p<0.0001). The study showed that Hyperuricemia is prevalent in adult Nigerians with newly diagnosed hypertension. Hyperuricemia was associated with left ventricular hypertrophy which is common target organ damage and confers an increased risk of cardiovascular events in systemic hypertension.
VL  - 7
IS  - 1
ER  -

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Author Information

Abidemi Jude Fasae

Department of Internal Medicine, Federal Teaching Hospital, Ido-Ekiti, Nigeria
Olusegun Adesola Busari

Department of Internal Medicine, Federal Teaching Hospital, Ido-Ekiti, Nigeria
Rotimi Oluyombo

Department of Internal Medicine, Federal Teaching Hospital, Ido-Ekiti, Nigeria
Musa Yusuf

Department of Internal Medicine, Federal Teaching Hospital, Ido-Ekiti, Nigeria
Oladipo George Opadijo

Department of Internal Medicine, Ladoke Akintola University Teaching Hospital, Ogbomoso, Nigeria
Ayodele Babatunde Omotoso

Department of Internal Medicine, University of Ilorin Teaching Hospital, Ilorin, Nigeria

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APA Style

Abidemi Jude Fasae, Olusegun Adesola Busari, Rotimi Oluyombo, Musa Yusuf, Oladipo George Opadijo, et al. (2018). Hyperuricemia and Its Correlation with Target Organ Damage and Electrocardiographic Changes in Newly Diagnosed Adult Nigerian Hypertensive Patients. Clinical Medicine Research, 7(1), 1-7. https://doi.org/10.11648/j.cmr.20180701.11

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ACS Style

Abidemi Jude Fasae; Olusegun Adesola Busari; Rotimi Oluyombo; Musa Yusuf; Oladipo George Opadijo, et al. Hyperuricemia and Its Correlation with Target Organ Damage and Electrocardiographic Changes in Newly Diagnosed Adult Nigerian Hypertensive Patients. Clin. Med. Res. 2018, 7(1), 1-7. doi: 10.11648/j.cmr.20180701.11

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AMA Style

Abidemi Jude Fasae, Olusegun Adesola Busari, Rotimi Oluyombo, Musa Yusuf, Oladipo George Opadijo, et al. Hyperuricemia and Its Correlation with Target Organ Damage and Electrocardiographic Changes in Newly Diagnosed Adult Nigerian Hypertensive Patients. Clin Med Res. 2018;7(1):1-7. doi: 10.11648/j.cmr.20180701.11

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@article{10.11648/j.cmr.20180701.11,
  author = {Abidemi Jude Fasae and Olusegun Adesola Busari and Rotimi Oluyombo and Musa Yusuf and Oladipo George Opadijo and Ayodele Babatunde Omotoso},
  title = {Hyperuricemia and Its Correlation with Target Organ Damage and Electrocardiographic Changes in Newly Diagnosed Adult Nigerian Hypertensive Patients},
  journal = {Clinical Medicine Research},
  volume = {7},
  number = {1},
  pages = {1-7},
  doi = {10.11648/j.cmr.20180701.11},
  url = {https://doi.org/10.11648/j.cmr.20180701.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.cmr.20180701.11},
  abstract = {The objective of the study was to determine the prevalence of Hyperuricemia and evaluate its correlation with target organ damage and electrocardiographic changes in newly diagnosed adult Nigerian hypertensive patients. It was a cross sectional study done at the University of Ilorin Teaching Hospital, Ilorin, Nigeria. 150 untreated newly diagnosed hypertensive patients 18 years and above and 115 age and sex-matched normotensive individuals were recruited into the study. Data obtained was analyzed using Epi-Info version 6.04 and Statistical Package for Social Sciences (SPSS) version 14 computer software packages. The prevalence of Hyperuricemia was 36.7% and 17.4% in hypertensive patients and normotensive controls respectively. Mean serum UA in hypertensive patients and normotensive controls was 0.4±0.1mmol/l and 0.3±0.1mmol/l respectively (p2=23.97, p<0.0001). The study showed that Hyperuricemia is prevalent in adult Nigerians with newly diagnosed hypertension. Hyperuricemia was associated with left ventricular hypertrophy which is common target organ damage and confers an increased risk of cardiovascular events in systemic hypertension.},
 year = {2018}
}

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TY  - JOUR
T1  - Hyperuricemia and Its Correlation with Target Organ Damage and Electrocardiographic Changes in Newly Diagnosed Adult Nigerian Hypertensive Patients
AU  - Abidemi Jude Fasae
AU  - Olusegun Adesola Busari
AU  - Rotimi Oluyombo
AU  - Musa Yusuf
AU  - Oladipo George Opadijo
AU  - Ayodele Babatunde Omotoso
Y1  - 2018/01/26
PY  - 2018
N1  - https://doi.org/10.11648/j.cmr.20180701.11
DO  - 10.11648/j.cmr.20180701.11
T2  - Clinical Medicine Research
JF  - Clinical Medicine Research
JO  - Clinical Medicine Research
SP  - 1
EP  - 7
PB  - Science Publishing Group
SN  - 2326-9057
UR  - https://doi.org/10.11648/j.cmr.20180701.11
AB  - The objective of the study was to determine the prevalence of Hyperuricemia and evaluate its correlation with target organ damage and electrocardiographic changes in newly diagnosed adult Nigerian hypertensive patients. It was a cross sectional study done at the University of Ilorin Teaching Hospital, Ilorin, Nigeria. 150 untreated newly diagnosed hypertensive patients 18 years and above and 115 age and sex-matched normotensive individuals were recruited into the study. Data obtained was analyzed using Epi-Info version 6.04 and Statistical Package for Social Sciences (SPSS) version 14 computer software packages. The prevalence of Hyperuricemia was 36.7% and 17.4% in hypertensive patients and normotensive controls respectively. Mean serum UA in hypertensive patients and normotensive controls was 0.4±0.1mmol/l and 0.3±0.1mmol/l respectively (p2=23.97, p<0.0001). The study showed that Hyperuricemia is prevalent in adult Nigerians with newly diagnosed hypertension. Hyperuricemia was associated with left ventricular hypertrophy which is common target organ damage and confers an increased risk of cardiovascular events in systemic hypertension.
VL  - 7
IS  - 1
ER  -

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