Wound infection still remains a significant cause of morbidly and mortality. Hence, studying the spectrum of bacterial etiological agents and their drug susceptibility profile is critical. A prospective study was conducted at Arsho Advanced Medical Laboratory from June 2016 to July 2017. Wound specimens were collected from 366 patients following standard procedures. Specimens were plated and incubated at 37°C for 48 hours. Identification and drug susceptibility testing of cultures were carried out by using the VITEK 2 compact system. Among 366 wound samples cultured, bacteria grew in 271(74%) samples. The highest (81.9%) wound infections were documented among patients with an age group of 15-64 years. Two hundred twenty one bacterial isolates were recovered of which 43.2% were Gram-negative while, 56.8% were Gram-positive. Staphylococcus aureus and Coagulase-Negative Staphylococci were major Gram-positive bacteria while Escherichia coli and Pseudomonas spp. were the commonest Gram-negative bacteria. Gram-negative bacteria had the highest overall drug resistance rate against ampicillin. Tobramycin and piperacillin/tazobactam combination were effective antimicrobial agents against Gram-negative bacteria. The highest overall resistance rate to Gram-positive bacteria was observed against erythromycin. Vancomycin and linezolid were the most active antimicrobial agents against Gram-positive bacteria. High culture positivity rate of wound infections reported in the present study initiates many similar studies to be conducted on wound in the country. High level of drug resistance to the commonly prescribed drugs dictates a search for better choices.
| Published in | Clinical Medicine Research (Volume 7, Issue 1) |
| DOI | 10.11648/j.cmr.20180701.12 |
| Page(s) | 8-17 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2018. Published by Science Publishing Group |
Wound Infections, Drug Suscetibity Pattern, Etiological Agents, Ethiopia
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APA Style
Adane Bitew, Mesele Admassie, Tigist Getachew. (2018). Spectrum and Drug Susceptibility Profile of Bacteria Recovered from Patients with Wound Infection Referred to Arsho Advanced Medical Laboratory. Clinical Medicine Research, 7(1), 8-17. https://doi.org/10.11648/j.cmr.20180701.12
ACS Style
Adane Bitew; Mesele Admassie; Tigist Getachew. Spectrum and Drug Susceptibility Profile of Bacteria Recovered from Patients with Wound Infection Referred to Arsho Advanced Medical Laboratory. Clin. Med. Res. 2018, 7(1), 8-17. doi: 10.11648/j.cmr.20180701.12
AMA Style
Adane Bitew, Mesele Admassie, Tigist Getachew. Spectrum and Drug Susceptibility Profile of Bacteria Recovered from Patients with Wound Infection Referred to Arsho Advanced Medical Laboratory. Clin Med Res. 2018;7(1):8-17. doi: 10.11648/j.cmr.20180701.12
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Download@article{10.11648/j.cmr.20180701.12,
author = {Adane Bitew and Mesele Admassie and Tigist Getachew},
title = {Spectrum and Drug Susceptibility Profile of Bacteria Recovered from Patients with Wound Infection Referred to Arsho Advanced Medical Laboratory},
journal = {Clinical Medicine Research},
volume = {7},
number = {1},
pages = {8-17},
doi = {10.11648/j.cmr.20180701.12},
url = {https://doi.org/10.11648/j.cmr.20180701.12},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.cmr.20180701.12},
abstract = {Wound infection still remains a significant cause of morbidly and mortality. Hence, studying the spectrum of bacterial etiological agents and their drug susceptibility profile is critical. A prospective study was conducted at Arsho Advanced Medical Laboratory from June 2016 to July 2017. Wound specimens were collected from 366 patients following standard procedures. Specimens were plated and incubated at 37°C for 48 hours. Identification and drug susceptibility testing of cultures were carried out by using the VITEK 2 compact system. Among 366 wound samples cultured, bacteria grew in 271(74%) samples. The highest (81.9%) wound infections were documented among patients with an age group of 15-64 years. Two hundred twenty one bacterial isolates were recovered of which 43.2% were Gram-negative while, 56.8% were Gram-positive. Staphylococcus aureus and Coagulase-Negative Staphylococci were major Gram-positive bacteria while Escherichia coli and Pseudomonas spp. were the commonest Gram-negative bacteria. Gram-negative bacteria had the highest overall drug resistance rate against ampicillin. Tobramycin and piperacillin/tazobactam combination were effective antimicrobial agents against Gram-negative bacteria. The highest overall resistance rate to Gram-positive bacteria was observed against erythromycin. Vancomycin and linezolid were the most active antimicrobial agents against Gram-positive bacteria. High culture positivity rate of wound infections reported in the present study initiates many similar studies to be conducted on wound in the country. High level of drug resistance to the commonly prescribed drugs dictates a search for better choices.},
year = {2018}
}
TY - JOUR T1 - Spectrum and Drug Susceptibility Profile of Bacteria Recovered from Patients with Wound Infection Referred to Arsho Advanced Medical Laboratory AU - Adane Bitew AU - Mesele Admassie AU - Tigist Getachew Y1 - 2018/03/07 PY - 2018 N1 - https://doi.org/10.11648/j.cmr.20180701.12 DO - 10.11648/j.cmr.20180701.12 T2 - Clinical Medicine Research JF - Clinical Medicine Research JO - Clinical Medicine Research SP - 8 EP - 17 PB - Science Publishing Group SN - 2326-9057 UR - https://doi.org/10.11648/j.cmr.20180701.12 AB - Wound infection still remains a significant cause of morbidly and mortality. Hence, studying the spectrum of bacterial etiological agents and their drug susceptibility profile is critical. A prospective study was conducted at Arsho Advanced Medical Laboratory from June 2016 to July 2017. Wound specimens were collected from 366 patients following standard procedures. Specimens were plated and incubated at 37°C for 48 hours. Identification and drug susceptibility testing of cultures were carried out by using the VITEK 2 compact system. Among 366 wound samples cultured, bacteria grew in 271(74%) samples. The highest (81.9%) wound infections were documented among patients with an age group of 15-64 years. Two hundred twenty one bacterial isolates were recovered of which 43.2% were Gram-negative while, 56.8% were Gram-positive. Staphylococcus aureus and Coagulase-Negative Staphylococci were major Gram-positive bacteria while Escherichia coli and Pseudomonas spp. were the commonest Gram-negative bacteria. Gram-negative bacteria had the highest overall drug resistance rate against ampicillin. Tobramycin and piperacillin/tazobactam combination were effective antimicrobial agents against Gram-negative bacteria. The highest overall resistance rate to Gram-positive bacteria was observed against erythromycin. Vancomycin and linezolid were the most active antimicrobial agents against Gram-positive bacteria. High culture positivity rate of wound infections reported in the present study initiates many similar studies to be conducted on wound in the country. High level of drug resistance to the commonly prescribed drugs dictates a search for better choices. VL - 7 IS - 1 ER -
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