Bone Marrow Metastases as an Initial Presentation of Gastrointestinal Adenocarcinoma: A Case Report

Molina-Arrebola María-Angustias; Fernández-Caballero Mariana; Avivar-Oyonarte Cristóbal; Jiménez-Cortés María-Carmen; Hidalgo-Rico María-Angeles

doi:doi:10.11648/j.cmr.20170604.12

Bone Marrow Metastases as an Initial Presentation of Gastrointestinal Adenocarcinoma: A Case Report

Molina-Arrebola María-Angustias, Fernández-Caballero Mariana, Avivar-Oyonarte Cristóbal, Jiménez-Cortés María-Carmen, Hidalgo-Rico María-Angeles

Published in Clinical Medicine Research (Volume 6, Issue 4)

Received: 13 February 2017 Accepted: 24 April 2017 Published: 14 June 2017

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Abstract

Bone marrow metastases as the initial presentation of a solid tumour are uncommon, especially if the primary neoplasm site cannot be identified during the diagnosis presentation despite laboratory testing and imaging techniques. In these situations, bone marrow examination can lead to a final diagnosis of the primary malignancy. We report an unusual case of osteoblastic metastases from an unknown primary site – this was because no relevant lesions were found from either imaging or endoscopic examination. The patient was sent for a bone marrow biopsy, revealing a morphology replaced by glandular structures and an immunohistochemistry consistent with a gastrointestinal origin. Bone marrow examination was the clue to the final diagnosis and led to specific treatment.

Published in	Clinical Medicine Research (Volume 6, Issue 4)
DOI	10.11648/j.cmr.20170604.12
Page(s)	127-130
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2017. Published by Science Publishing Group

Keywords

Bone Marrow, Metastases, Solid Tumour, Immunohistochemistry

References

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Molina-Arrebola María-Angustias, Fernández-Caballero Mariana, Avivar-Oyonarte Cristóbal, Jiménez-Cortés María-Carmen, Hidalgo-Rico María-Angeles. (2017). Bone Marrow Metastases as an Initial Presentation of Gastrointestinal Adenocarcinoma: A Case Report. Clinical Medicine Research, 6(4), 127-130. https://doi.org/10.11648/j.cmr.20170604.12

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ACS Style

Molina-Arrebola María-Angustias; Fernández-Caballero Mariana; Avivar-Oyonarte Cristóbal; Jiménez-Cortés María-Carmen; Hidalgo-Rico María-Angeles. Bone Marrow Metastases as an Initial Presentation of Gastrointestinal Adenocarcinoma: A Case Report. Clin. Med. Res. 2017, 6(4), 127-130. doi: 10.11648/j.cmr.20170604.12

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AMA Style

Molina-Arrebola María-Angustias, Fernández-Caballero Mariana, Avivar-Oyonarte Cristóbal, Jiménez-Cortés María-Carmen, Hidalgo-Rico María-Angeles. Bone Marrow Metastases as an Initial Presentation of Gastrointestinal Adenocarcinoma: A Case Report. Clin Med Res. 2017;6(4):127-130. doi: 10.11648/j.cmr.20170604.12

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@article{10.11648/j.cmr.20170604.12,
  author = {Molina-Arrebola María-Angustias and Fernández-Caballero Mariana and Avivar-Oyonarte Cristóbal and Jiménez-Cortés María-Carmen and Hidalgo-Rico María-Angeles},
  title = {Bone Marrow Metastases as an Initial Presentation of Gastrointestinal Adenocarcinoma: A Case Report},
  journal = {Clinical Medicine Research},
  volume = {6},
  number = {4},
  pages = {127-130},
  doi = {10.11648/j.cmr.20170604.12},
  url = {https://doi.org/10.11648/j.cmr.20170604.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.cmr.20170604.12},
  abstract = {Bone marrow metastases as the initial presentation of a solid tumour are uncommon, especially if the primary neoplasm site cannot be identified during the diagnosis presentation despite laboratory testing and imaging techniques. In these situations, bone marrow examination can lead to a final diagnosis of the primary malignancy. We report an unusual case of osteoblastic metastases from an unknown primary site – this was because no relevant lesions were found from either imaging or endoscopic examination. The patient was sent for a bone marrow biopsy, revealing a morphology replaced by glandular structures and an immunohistochemistry consistent with a gastrointestinal origin. Bone marrow examination was the clue to the final diagnosis and led to specific treatment.},
 year = {2017}
}

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TY  - JOUR
T1  - Bone Marrow Metastases as an Initial Presentation of Gastrointestinal Adenocarcinoma: A Case Report
AU  - Molina-Arrebola María-Angustias
AU  - Fernández-Caballero Mariana
AU  - Avivar-Oyonarte Cristóbal
AU  - Jiménez-Cortés María-Carmen
AU  - Hidalgo-Rico María-Angeles
Y1  - 2017/06/14
PY  - 2017
N1  - https://doi.org/10.11648/j.cmr.20170604.12
DO  - 10.11648/j.cmr.20170604.12
T2  - Clinical Medicine Research
JF  - Clinical Medicine Research
JO  - Clinical Medicine Research
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EP  - 130
PB  - Science Publishing Group
SN  - 2326-9057
UR  - https://doi.org/10.11648/j.cmr.20170604.12
AB  - Bone marrow metastases as the initial presentation of a solid tumour are uncommon, especially if the primary neoplasm site cannot be identified during the diagnosis presentation despite laboratory testing and imaging techniques. In these situations, bone marrow examination can lead to a final diagnosis of the primary malignancy. We report an unusual case of osteoblastic metastases from an unknown primary site – this was because no relevant lesions were found from either imaging or endoscopic examination. The patient was sent for a bone marrow biopsy, revealing a morphology replaced by glandular structures and an immunohistochemistry consistent with a gastrointestinal origin. Bone marrow examination was the clue to the final diagnosis and led to specific treatment.
VL  - 6
IS  - 4
ER  -

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Author Information

Molina-Arrebola María-Angustias

Department of Biotechnology, Haematology and Haemotherapy Unit, Poniente Hospital, Almería, Spain
Fernández-Caballero Mariana

Department of Biotechnology, Haematology and Haemotherapy Unit, Poniente Hospital, Almería, Spain
Avivar-Oyonarte Cristóbal

Department of Biotechnology, Poniente Hospital, Almería, Spain
Jiménez-Cortés María-Carmen

Department of Biotechnology, Pathology Unit, Poniente Hospital, Almería, Spain
Hidalgo-Rico María-Angeles

Department of Internal Medicine, Pulmonology Unit, Poniente Hospital, Almería, Spain

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APA Style

Molina-Arrebola María-Angustias, Fernández-Caballero Mariana, Avivar-Oyonarte Cristóbal, Jiménez-Cortés María-Carmen, Hidalgo-Rico María-Angeles. (2017). Bone Marrow Metastases as an Initial Presentation of Gastrointestinal Adenocarcinoma: A Case Report. Clinical Medicine Research, 6(4), 127-130. https://doi.org/10.11648/j.cmr.20170604.12

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ACS Style

Molina-Arrebola María-Angustias; Fernández-Caballero Mariana; Avivar-Oyonarte Cristóbal; Jiménez-Cortés María-Carmen; Hidalgo-Rico María-Angeles. Bone Marrow Metastases as an Initial Presentation of Gastrointestinal Adenocarcinoma: A Case Report. Clin. Med. Res. 2017, 6(4), 127-130. doi: 10.11648/j.cmr.20170604.12

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AMA Style

Molina-Arrebola María-Angustias, Fernández-Caballero Mariana, Avivar-Oyonarte Cristóbal, Jiménez-Cortés María-Carmen, Hidalgo-Rico María-Angeles. Bone Marrow Metastases as an Initial Presentation of Gastrointestinal Adenocarcinoma: A Case Report. Clin Med Res. 2017;6(4):127-130. doi: 10.11648/j.cmr.20170604.12

Copy | Download

@article{10.11648/j.cmr.20170604.12,
  author = {Molina-Arrebola María-Angustias and Fernández-Caballero Mariana and Avivar-Oyonarte Cristóbal and Jiménez-Cortés María-Carmen and Hidalgo-Rico María-Angeles},
  title = {Bone Marrow Metastases as an Initial Presentation of Gastrointestinal Adenocarcinoma: A Case Report},
  journal = {Clinical Medicine Research},
  volume = {6},
  number = {4},
  pages = {127-130},
  doi = {10.11648/j.cmr.20170604.12},
  url = {https://doi.org/10.11648/j.cmr.20170604.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.cmr.20170604.12},
  abstract = {Bone marrow metastases as the initial presentation of a solid tumour are uncommon, especially if the primary neoplasm site cannot be identified during the diagnosis presentation despite laboratory testing and imaging techniques. In these situations, bone marrow examination can lead to a final diagnosis of the primary malignancy. We report an unusual case of osteoblastic metastases from an unknown primary site – this was because no relevant lesions were found from either imaging or endoscopic examination. The patient was sent for a bone marrow biopsy, revealing a morphology replaced by glandular structures and an immunohistochemistry consistent with a gastrointestinal origin. Bone marrow examination was the clue to the final diagnosis and led to specific treatment.},
 year = {2017}
}

Copy | Download

TY  - JOUR
T1  - Bone Marrow Metastases as an Initial Presentation of Gastrointestinal Adenocarcinoma: A Case Report
AU  - Molina-Arrebola María-Angustias
AU  - Fernández-Caballero Mariana
AU  - Avivar-Oyonarte Cristóbal
AU  - Jiménez-Cortés María-Carmen
AU  - Hidalgo-Rico María-Angeles
Y1  - 2017/06/14
PY  - 2017
N1  - https://doi.org/10.11648/j.cmr.20170604.12
DO  - 10.11648/j.cmr.20170604.12
T2  - Clinical Medicine Research
JF  - Clinical Medicine Research
JO  - Clinical Medicine Research
SP  - 127
EP  - 130
PB  - Science Publishing Group
SN  - 2326-9057
UR  - https://doi.org/10.11648/j.cmr.20170604.12
AB  - Bone marrow metastases as the initial presentation of a solid tumour are uncommon, especially if the primary neoplasm site cannot be identified during the diagnosis presentation despite laboratory testing and imaging techniques. In these situations, bone marrow examination can lead to a final diagnosis of the primary malignancy. We report an unusual case of osteoblastic metastases from an unknown primary site – this was because no relevant lesions were found from either imaging or endoscopic examination. The patient was sent for a bone marrow biopsy, revealing a morphology replaced by glandular structures and an immunohistochemistry consistent with a gastrointestinal origin. Bone marrow examination was the clue to the final diagnosis and led to specific treatment.
VL  - 6
IS  - 4
ER  -

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