Weaning Outcomes and Clinical Characteristics of Severe Mechanically Ventilated COVID-19 Patients During the Three Waves of the COVID-19 Pandemic in Israel

David Ovadya; Sireen Abuakar; Kevin Felner

doi:doi:10.11648/j.cmr.20211006.18

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Weaning Outcomes and Clinical Characteristics of Severe Mechanically Ventilated COVID-19 Patients During the Three Waves of the COVID-19 Pandemic in Israel

David Ovadya, Sireen Abuakar, Kevin Felner

Published in Clinical Medicine Research (Volume 10, Issue 6)

Received: 10 November 2021 Accepted: 8 December 2021 Published: 24 December 2021

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Abstract

Background: Most of severe COVID-19 patients who survive the intensive care remain mechanically ventilated and require weaning and further rehabilitation. Objectives: This study compares the characteristics and outcomes of severe mechanically ventilated COVID-19 patients admitted to a weaning facility. In addition, the study describes patterns of weaning experienced during the three waves of COVID-19 in Israel. Methods: Clinical, demographic and outcome data was gathered retrospectively for 70 severe mechanically ventilated patients. Univariate analysis was performed to explain the variability in outcome variables. Results: Weaning success was 94% with mean weaning duration of 13±17 days. None of the demographic and clinical variables examined influenced the weaning duration, however patients with morbid obesity and/or diabetes were found to have shorter total duration on mechanical ventilation, hereby suggesting the presence of an obesity paradox. Extra corporal membrane oxygenation (ECMO) was used in 29% of the patients, and didn’t influence the weaning duration in spite being associated with higher rate of pleural complication. There were three main weaning patterns seen in different overlapping levels in the cohort patients: low capacity extra pulmonary pattern, fibrotic-bullosic pulmonary injury pattern and nonspecific interstitial pneumonitis pattern. Conclusions: The current study shows a high success rate of weaning, independent on comorbidities and previous ECMO use.

Published in	Clinical Medicine Research (Volume 10, Issue 6)
DOI	10.11648/j.cmr.20211006.18
Page(s)	225-230
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2021. Published by Science Publishing Group

Keywords

COVID-19, Obesity Paradox, Weaning, Mechanical Ventilation

References

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APA Style

David Ovadya, Sireen Abuakar, Kevin Felner. (2021). Weaning Outcomes and Clinical Characteristics of Severe Mechanically Ventilated COVID-19 Patients During the Three Waves of the COVID-19 Pandemic in Israel. Clinical Medicine Research, 10(6), 225-230. https://doi.org/10.11648/j.cmr.20211006.18

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ACS Style

David Ovadya; Sireen Abuakar; Kevin Felner. Weaning Outcomes and Clinical Characteristics of Severe Mechanically Ventilated COVID-19 Patients During the Three Waves of the COVID-19 Pandemic in Israel. Clin. Med. Res. 2021, 10(6), 225-230. doi: 10.11648/j.cmr.20211006.18

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AMA Style

David Ovadya, Sireen Abuakar, Kevin Felner. Weaning Outcomes and Clinical Characteristics of Severe Mechanically Ventilated COVID-19 Patients During the Three Waves of the COVID-19 Pandemic in Israel. Clin Med Res. 2021;10(6):225-230. doi: 10.11648/j.cmr.20211006.18

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@article{10.11648/j.cmr.20211006.18,
  author = {David Ovadya and Sireen Abuakar and Kevin Felner},
  title = {Weaning Outcomes and Clinical Characteristics of Severe Mechanically Ventilated COVID-19 Patients During the Three Waves of the COVID-19 Pandemic in Israel},
  journal = {Clinical Medicine Research},
  volume = {10},
  number = {6},
  pages = {225-230},
  doi = {10.11648/j.cmr.20211006.18},
  url = {https://doi.org/10.11648/j.cmr.20211006.18},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.cmr.20211006.18},
  abstract = {Background: Most of severe COVID-19 patients who survive the intensive care remain mechanically ventilated and require weaning and further rehabilitation. Objectives: This study compares the characteristics and outcomes of severe mechanically ventilated COVID-19 patients admitted to a weaning facility. In addition, the study describes patterns of weaning experienced during the three waves of COVID-19 in Israel. Methods: Clinical, demographic and outcome data was gathered retrospectively for 70 severe mechanically ventilated patients. Univariate analysis was performed to explain the variability in outcome variables. Results: Weaning success was 94% with mean weaning duration of 13±17 days. None of the demographic and clinical variables examined influenced the weaning duration, however patients with morbid obesity and/or diabetes were found to have shorter total duration on mechanical ventilation, hereby suggesting the presence of an obesity paradox. Extra corporal membrane oxygenation (ECMO) was used in 29% of the patients, and didn’t influence the weaning duration in spite being associated with higher rate of pleural complication. There were three main weaning patterns seen in different overlapping levels in the cohort patients: low capacity extra pulmonary pattern, fibrotic-bullosic pulmonary injury pattern and nonspecific interstitial pneumonitis pattern. Conclusions: The current study shows a high success rate of weaning, independent on comorbidities and previous ECMO use.},
 year = {2021}
}

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TY  - JOUR
T1  - Weaning Outcomes and Clinical Characteristics of Severe Mechanically Ventilated COVID-19 Patients During the Three Waves of the COVID-19 Pandemic in Israel
AU  - David Ovadya
AU  - Sireen Abuakar
AU  - Kevin Felner
Y1  - 2021/12/24
PY  - 2021
N1  - https://doi.org/10.11648/j.cmr.20211006.18
DO  - 10.11648/j.cmr.20211006.18
T2  - Clinical Medicine Research
JF  - Clinical Medicine Research
JO  - Clinical Medicine Research
SP  - 225
EP  - 230
PB  - Science Publishing Group
SN  - 2326-9057
UR  - https://doi.org/10.11648/j.cmr.20211006.18
AB  - Background: Most of severe COVID-19 patients who survive the intensive care remain mechanically ventilated and require weaning and further rehabilitation. Objectives: This study compares the characteristics and outcomes of severe mechanically ventilated COVID-19 patients admitted to a weaning facility. In addition, the study describes patterns of weaning experienced during the three waves of COVID-19 in Israel. Methods: Clinical, demographic and outcome data was gathered retrospectively for 70 severe mechanically ventilated patients. Univariate analysis was performed to explain the variability in outcome variables. Results: Weaning success was 94% with mean weaning duration of 13±17 days. None of the demographic and clinical variables examined influenced the weaning duration, however patients with morbid obesity and/or diabetes were found to have shorter total duration on mechanical ventilation, hereby suggesting the presence of an obesity paradox. Extra corporal membrane oxygenation (ECMO) was used in 29% of the patients, and didn’t influence the weaning duration in spite being associated with higher rate of pleural complication. There were three main weaning patterns seen in different overlapping levels in the cohort patients: low capacity extra pulmonary pattern, fibrotic-bullosic pulmonary injury pattern and nonspecific interstitial pneumonitis pattern. Conclusions: The current study shows a high success rate of weaning, independent on comorbidities and previous ECMO use.
VL  - 10
IS  - 6
ER  -

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Author Information

David Ovadya

Department of Respiratory Rehabilitation, Sheba Medical Center at Tel-Hashomer, Ramat Gan, Israel
Sireen Abuakar

Department of Respiratory Rehabilitation, Sheba Medical Center at Tel-Hashomer, Ramat Gan, Israel
Kevin Felner

Department of Respiratory Rehabilitation, Sheba Medical Center at Tel-Hashomer, Ramat Gan, Israel

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Plain Text BibTeX RIS

APA Style

David Ovadya, Sireen Abuakar, Kevin Felner. (2021). Weaning Outcomes and Clinical Characteristics of Severe Mechanically Ventilated COVID-19 Patients During the Three Waves of the COVID-19 Pandemic in Israel. Clinical Medicine Research, 10(6), 225-230. https://doi.org/10.11648/j.cmr.20211006.18

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ACS Style

David Ovadya; Sireen Abuakar; Kevin Felner. Weaning Outcomes and Clinical Characteristics of Severe Mechanically Ventilated COVID-19 Patients During the Three Waves of the COVID-19 Pandemic in Israel. Clin. Med. Res. 2021, 10(6), 225-230. doi: 10.11648/j.cmr.20211006.18

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AMA Style

David Ovadya, Sireen Abuakar, Kevin Felner. Weaning Outcomes and Clinical Characteristics of Severe Mechanically Ventilated COVID-19 Patients During the Three Waves of the COVID-19 Pandemic in Israel. Clin Med Res. 2021;10(6):225-230. doi: 10.11648/j.cmr.20211006.18

Copy | Download

@article{10.11648/j.cmr.20211006.18,
  author = {David Ovadya and Sireen Abuakar and Kevin Felner},
  title = {Weaning Outcomes and Clinical Characteristics of Severe Mechanically Ventilated COVID-19 Patients During the Three Waves of the COVID-19 Pandemic in Israel},
  journal = {Clinical Medicine Research},
  volume = {10},
  number = {6},
  pages = {225-230},
  doi = {10.11648/j.cmr.20211006.18},
  url = {https://doi.org/10.11648/j.cmr.20211006.18},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.cmr.20211006.18},
  abstract = {Background: Most of severe COVID-19 patients who survive the intensive care remain mechanically ventilated and require weaning and further rehabilitation. Objectives: This study compares the characteristics and outcomes of severe mechanically ventilated COVID-19 patients admitted to a weaning facility. In addition, the study describes patterns of weaning experienced during the three waves of COVID-19 in Israel. Methods: Clinical, demographic and outcome data was gathered retrospectively for 70 severe mechanically ventilated patients. Univariate analysis was performed to explain the variability in outcome variables. Results: Weaning success was 94% with mean weaning duration of 13±17 days. None of the demographic and clinical variables examined influenced the weaning duration, however patients with morbid obesity and/or diabetes were found to have shorter total duration on mechanical ventilation, hereby suggesting the presence of an obesity paradox. Extra corporal membrane oxygenation (ECMO) was used in 29% of the patients, and didn’t influence the weaning duration in spite being associated with higher rate of pleural complication. There were three main weaning patterns seen in different overlapping levels in the cohort patients: low capacity extra pulmonary pattern, fibrotic-bullosic pulmonary injury pattern and nonspecific interstitial pneumonitis pattern. Conclusions: The current study shows a high success rate of weaning, independent on comorbidities and previous ECMO use.},
 year = {2021}
}

Copy | Download

TY  - JOUR
T1  - Weaning Outcomes and Clinical Characteristics of Severe Mechanically Ventilated COVID-19 Patients During the Three Waves of the COVID-19 Pandemic in Israel
AU  - David Ovadya
AU  - Sireen Abuakar
AU  - Kevin Felner
Y1  - 2021/12/24
PY  - 2021
N1  - https://doi.org/10.11648/j.cmr.20211006.18
DO  - 10.11648/j.cmr.20211006.18
T2  - Clinical Medicine Research
JF  - Clinical Medicine Research
JO  - Clinical Medicine Research
SP  - 225
EP  - 230
PB  - Science Publishing Group
SN  - 2326-9057
UR  - https://doi.org/10.11648/j.cmr.20211006.18
AB  - Background: Most of severe COVID-19 patients who survive the intensive care remain mechanically ventilated and require weaning and further rehabilitation. Objectives: This study compares the characteristics and outcomes of severe mechanically ventilated COVID-19 patients admitted to a weaning facility. In addition, the study describes patterns of weaning experienced during the three waves of COVID-19 in Israel. Methods: Clinical, demographic and outcome data was gathered retrospectively for 70 severe mechanically ventilated patients. Univariate analysis was performed to explain the variability in outcome variables. Results: Weaning success was 94% with mean weaning duration of 13±17 days. None of the demographic and clinical variables examined influenced the weaning duration, however patients with morbid obesity and/or diabetes were found to have shorter total duration on mechanical ventilation, hereby suggesting the presence of an obesity paradox. Extra corporal membrane oxygenation (ECMO) was used in 29% of the patients, and didn’t influence the weaning duration in spite being associated with higher rate of pleural complication. There were three main weaning patterns seen in different overlapping levels in the cohort patients: low capacity extra pulmonary pattern, fibrotic-bullosic pulmonary injury pattern and nonspecific interstitial pneumonitis pattern. Conclusions: The current study shows a high success rate of weaning, independent on comorbidities and previous ECMO use.
VL  - 10
IS  - 6
ER  -

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