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Effect of Regular Physical Exercise on the Progression of Erectile Dysfunction Among Male Patients with Diabetes Mellitus

Received: 8 July 2020     Accepted: 20 July 2020     Published: 30 July 2020
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Abstract

There is no agreed management for Erectile Dysfunction (ED) for male patients with Diabetes Mellitus (DM). Regular Physical Exercise (PE) starts to be a more exciting area that needs further focus. This review attempts to gather available data about the ED burden, etiology, risk factors, assessment, and management. Further, it highlights the available evidence on the effect of PE on the progression of ED and the possible underline mechanisms. The available evidence is hugely supportive of the beneficial role of PE in the ED. The cardiovascular, neurological, endothelial, metabolic, and overall health benefits of PE are repeated mechanisms reported by many researchers. The possible explanation is quite not clear due to the complexity and bidirectional effect on many aspects related to the changes during PE. Further interventional studies are needed to determine the superiority of each factor. All physicians managing DM and ED are strongly invited to involve PE as part of their management plan in conjunction with other available treatment options. Research has to look after which type, duration, frequency, and intensity of PE is sufficient for detectable improvement in ED.

Published in Clinical Medicine Research (Volume 9, Issue 4)
DOI 10.11648/j.cmr.20200904.12
Page(s) 74-84
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2020. Published by Science Publishing Group

Keywords

Diabetes Mellitus, Erectile Dysfunction, Physical Exercise, Male

References
[1] Chu, Neelima V and Steven V Edelman. "Diabetes and Erectile Dysfunction." Clinical diabetes, vol. 19, no. 1, 2001, pp. 45-47.
[2] Nimesh, Saurabh et al. "Erectile Dysfunction: An Update." Advances in Medical, Dental and Health Sciences, vol. 2, no. 1, 2019.
[3] Consensus, NIH. "Development Panel on Impotence. Nih Consensus Conference. Impotence." Jama, vol. 270, 1993, pp. 83-90.
[4] Braun, Moritz et al. "Epidemiology of Erectile Dysfunction: Results of the ‘Cologne Male Survey’." International journal of impotence research, vol. 12, no. 6, 2000, pp. 305-311.
[5] Martin-Morales, Antonio et al. "Prevalence and Independent Risk Factors for Erectile Dysfunction in Spain: Results of the Epidemiologia De La Disfuncion Erectil Masculina Study." The Journal of urology, vol. 166, no. 2, 2001, pp. 569-575.
[6] Blanker, Marco H et al. "Erectile and Ejaculatory Dysfunction in a Community-Based Sample of Men 50 to 78 Years Old: Prevalence, Concern, and Relation to Sexual Activity." Urology, vol. 57, no. 4, 2001, pp. 763-768.
[7] Selvin, Elizabeth et al. "Prevalence and Risk Factors for Erectile Dysfunction in the Us." The American journal of medicine, vol. 120, no. 2, 2007, pp. 151-157.
[8] Prins, Jan et al. "Prevalence of Erectile Dysfunction: A Systematic Review of Population-Based Studies." International journal of impotence research, vol. 14, no. 6, 2002, pp. 422-432.
[9] Maiorino, Maria Ida et al. "Diabetes and Sexual Dysfunction: Current Perspectives." Diabetes, metabolic syndrome and obesity: targets and therapy, vol. 7, 2014, p. 95.
[10] Kamenov, ZA. "A Comprehensive Review of Erectile Dysfunction in Men with Diabetes." Experimental and Clinical Endocrinology & Diabetes, vol. 123, no. 03, 2015, pp. 141-158.
[11] Grover, Steven A et al. "The Prevalence of Erectile Dysfunction in the Primary Care Setting: Importance of Risk Factors for Diabetes and Vascular Disease." Archives of internal medicine, vol. 166, no. 2, 2006, pp. 213-219.
[12] Feldman, Henry A et al. "Erectile Dysfunction and Coronary Risk Factors: Prospective Results from the Massachusetts Male Aging Study." Preventive Medicine, vol. 30, no. 4, 2000, pp. 328-338.
[13] Fung, Maple M et al. "Heart Disease Risk Factors Predict Erectile Dysfunction 25 Years Later: The Rancho Bernardo Study." Journal of the American College of Cardiology, vol. 43, no. 8, 2004, pp. 1405-1411.
[14] Bacon, Constance G et al. "Sexual Function in Men Older Than 50 Years of Age: Results from the Health Professionals Follow-up Study." Annals of internal medicine, vol. 139, no. 3, 2003, pp. 161-168.
[15] Al-yafei, Anees et al. "Assessment of Cardiovascular Disease Risk among Qatari Patients with Type 2 Diabetes Mellitus, Attending Primary Health Care Centers, 2014." The Open Diabetes Journal, vol. 10, no. 1, 2020.
[16] Inman, Brant A et al. "A Population-Based, Longitudinal Study of Erectile Dysfunction and Future Coronary Artery Disease." Mayo Clinic Proceedings, vol. 84, Elsevier, 2009, pp. 108-113.
[17] Chung, Shiu‐Dong et al. "Increased Risk of Stroke among Men with Erectile Dysfunction: A Nationwide Population‐Based Study." The journal of sexual medicine, vol. 8, no. 1, 2011, pp. 240-246.
[18] Dong, Jia-Yi et al. "Erectile Dysfunction and Risk of Cardiovascular Disease: Meta-Analysis of Prospective Cohort Studies." Journal of the American College of Cardiology, vol. 58, no. 13, 2011, pp. 1378-1385.
[19] Blanker, Marco H et al. "Correlates for Erectile and Ejaculatory Dysfunction in Older Dutch Men: A Community‐Based Study." Journal of the American Geriatrics Society, vol. 49, no. 4, 2001, pp. 436-442.
[20] Derby, Carol A et al. "Modifiable Risk Factors and Erectile Dysfunction: Can Lifestyle Changes Modify Risk?" Urology, vol. 56, no. 2, 2000, pp. 302-306.
[21] Huang, Paul L. "A Comprehensive Definition for Metabolic Syndrome." Disease models & mechanisms, vol. 2, no. 5-6, 2009, pp. 231-237.
[22] Demir, Omer et al. "Association between Severity of Lower Urinary Tract Symptoms, Erectile Dysfunction and Metabolic Syndrome." The Aging Male, vol. 12, no. 1, 2009, pp. 29-34.
[23] Kupelian, Varant et al. "Erectile Dysfunction as a Predictor of the Metabolic Syndrome in Aging Men: Results from the Massachusetts Male Aging Study." The Journal of urology, vol. 176, no. 1, 2006, pp. 222-226.
[24] De Nunzio, Cosimo et al. "Erectile Dysfunction and Lower Urinary Tract Symptoms." European urology focus, vol. 3, no. 4-5, 2017, pp. 352-363.
[25] Zheng, Hui et al. "Predictors for Erectile Dysfunction among Diabetics." Diabetes research and clinical practice, vol. 71, no. 3, 2006, pp. 313-319.
[26] Shabsigh, Ridwan et al. "Sexual Dysfunction and Depression: Etiology, Prevalence, and Treatment." Current urology reports, vol. 2, no. 6, 2001, pp. 463-467.
[27] Seidman, Stuart N and Steven P Roose. "Sexual Dysfunction and Depression." Current psychiatry reports, vol. 3, no. 3, 2001, pp. 202-208.
[28] F Adeniyi, Ade et al. "Diabetes, Sexual Dysfunction and Therapeutic Exercise: A 20 Year Review." Current diabetes reviews, vol. 6, no. 4, 2010, pp. 201-206.
[29] Zheng, Hong et al. "Lack of Central Nitric Oxide Triggers Erectile Dysfunction in Diabetes." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, vol. 292, no. 3, 2007, pp. R1158-R1164.
[30] Moore, Charles R and Run Wang. "Pathophysiology and Treatment of Diabetic Erectile Dysfunction." Asian journal of andrology, vol. 8, no. 6, 2006, pp. 675-684.
[31] Thorve, Vrushali S et al. "Diabetes-Induced Erectile Dysfunction: Epidemiology, Pathophysiology and Management." Journal of Diabetes and its Complications, vol. 25, no. 2, 2011, pp. 129-136.
[32] Rosen, Raymond C et al. "Development and Evaluation of an Abridged, 5-Item Version of the International Index of Erectile Function (Iief-5) as a Diagnostic Tool for Erectile Dysfunction." International journal of impotence research, vol. 11, no. 6, 1999, pp. 319-326.
[33] Rosen, Raymond C et al. "The International Index of Erectile Function (Iief): A Multidimensional Scale for Assessment of Erectile Dysfunction." Urology, vol. 49, no. 6, 1997, pp. 822-830.
[34] Ghanem, Hussein and Rany Shamloul. "An Evidence-Based Perspective to Commonly Performed Erectile Dysfunction Investigations." The journal of sexual medicine, vol. 5, no. 7, 2008, pp. 1582-1589.
[35] Cappelleri, JC and RC Rosen. "The Sexual Health Inventory for Men (Shim): A 5-Year Review of Research and Clinical Experience." International journal of impotence research, vol. 17, no. 4, 2005, pp. 307-319.
[36] Shamloul, Rany and Hussein Ghanem. "Erectile Dysfunction." The Lancet, vol. 381, no. 9861, 2013, pp. 153-165.
[37] Jain, Pankaj et al. "Testosterone Supplementation for Erectile Dysfunction: Results of a Meta-Analysis." The Journal of urology, vol. 164, no. 2, 2000, pp. 371-375.
[38] Shabsigh, R et al. "Randomized Study of Testosterone Gel as Adjunctive Therapy to Sildenafil in Hypogonadal Men with Erectile Dysfunction Who Do Not Respond to Sildenafil Alone." Ibid. vol. 179, no. 5, 2008, pp. S97-S102.
[39] Shamloul, Rany et al. "Testosterone Therapy Can Enhance Erectile Function Response to Sildenafil in Patients with Padam: A Pilot Study." The journal of sexual medicine, vol. 2, no. 4, 2005, pp. 559-564.
[40] Hatzimouratidis, Konstantinos and Dimitrios G Hatzichristou. "A Comparative Review of the Options for Treatment of Erectile Dysfunction." Drugs, vol. 65, no. 12, 2005, pp. 1621-1650.
[41] Perimenis, P et al. "Long‐Term Treatment with Intracavernosal Injections in Diabetic Men with Erectile Dysfunction." Asian journal of andrology, vol. 8, no. 2, 2006, pp. 219-224.
[42] Hartmut, P and B Jacques. "Standard Practice in Sexual Medicine." Philadelphia: Blackwell, 2006.
[43] Esposito, Katherine and Dario Giugliano. "Obesity, the Metabolic Syndrome, and Sexual Dysfunction." International journal of impotence research, vol. 17, no. 5, 2005, pp. 391-398.
[44] Penson, David F et al. "Do Impotent Men with Diabetes Have More Severe Erectile Dysfunction and Worse Quality of Life Than the General Population of Impotent Patients?: Results from the Exploratory Comprehensive Evaluation of Erectile Dysfunction (Exceed) Database." Diabetes care, vol. 26, no. 4, 2003, pp. 1093-1099.
[45] Alyafei, Anees and Wadha Albaker. "Barriers and Facilitators for Regular Physical Exercise among Adult Females Narrative Review 2020." Journal of Community Medicine & Public Health, 2020.
[46] Medicine, American College of Sports. Acsm's Health-Related Physical Fitness Assessment Manual. Lippincott Williams & Wilkins, 2013.
[47] Alyafei, Anees "Is Exercise Real Medicine." 2019, doi: 10.13140/RG.2.2.25735.21920..
[48] Colberg, Sheri R et al. "Exercise and Type 2 Diabetes: The American College of Sports Medicine and the American Diabetes Association: Joint Position Statement." Diabetes care, vol. 33, no. 12, 2010, pp. e147-e167.
[49] Caldeira, AO and AJ Leggett. "Erratum Ibid." Ann Phys (NY), vol. 153, 1983, p. 445.
[50] Colberg, Sheri R et al. "Physical Activity/Exercise and Diabetes: A Position Statement of the American Diabetes Association." Diabetes care, vol. 39, no. 11, 2016, pp. 2065-2079.
[51] Van Kampen, Marijke et al. "Treatment of Erectile Dysfunction by Perineal Exercise, Electromyographic Biofeedback, and Electrical Stimulation." Physical therapy, vol. 83, no. 6, 2003, pp. 536-543.
[52] Nicolosi, Alfredo et al. "A Population Study of the Association between Sexual Function, Sexual Satisfaction and Depressive Symptoms in Men." Journal of affective disorders, vol. 82, no. 2, 2004, pp. 235-243.
[53] Lamina, Sikiru et al. "Therapeutic Effect of an Interval Exercise Training Program in the Management of Erectile Dysfunction in Hypertensive Patients." The Journal of Clinical Hypertension, vol. 11, no. 3, 2009, pp. 125-129.
[54] Kałka, D et al. "Evaluation of Ambulatory Cardiac Rehabilitation Influence on the Intensity of Erectile Dysfunction in Patients with Ischemic Heart Disease." Polski merkuriusz lekarski: organ Polskiego Towarzystwa Lekarskiego, vol. 27, no. 160, 2009, pp. 290-295.
[55] Mak, Rudolf et al. "Prevalence and Correlates of Erectile Dysfunction in a Population-Based Study in Belgium." European urology, vol. 41, no. 2, 2002, pp. 132-138.
[56] Tan, JK et al. "Erectile Dysfunction in Singapore: Prevalence and Its Associated Factors—a Population-Based Study." Singapore Med J, vol. 44, no. 1, 2003, pp. 20-26.
[57] Maio, Giuseppe et al. "Physical Activity and Pde5 Inhibitors in the Treatment of Erectile Dysfunction: Results of a Randomized Controlled Study." The journal of sexual medicine, vol. 7, no. 6, 2010, pp. 2201-2208.
[58] Wing, Rena R et al. "Effects of Weight Loss Intervention on Erectile Function in Older Men with Type 2 Diabetes in the Look Ahead Trial." Ibid. no. 1, pp. 156-165.
[59] Shaeer, KZM et al. "Prevalence of Erectile Dysfunction and Its Correlates among Men Attending Primary Care Clinics in Three Countries: Pakistan, Egypt, and Nigeria." International journal of impotence research, vol. 15, no. 1, 2003, pp. S8-S14.
[60] Moreira Jr, Eduardo Duarte et al. "Prevalence and Correlates of Erectile Dysfunction in Salvador, Northeastern Brazil: A Population-Based Study." Ibid. vol. 14, no. 2, 2002, pp. S3-S9.
[61] Akkus, Emre et al. "Prevalence and Correlates of Erectile Dysfunction in Turkey: A Population-Based Study." European urology, vol. 41, no. 3, 2002, pp. 298-304.
[62] Nicolosi, Alfredo et al. "Epidemiology of Erectile Dysfunction in Four Countries: Cross-National Study of the Prevalence and Correlates of Erectile Dysfunction." Urology, vol. 61, no. 1, 2003, pp. 201-206.
[63] Cho, BL et al. "Prevalence and Risk Factors for Erectile Dysfuntion in Primary Care: Results of a Korean Study." International journal of impotence research, vol. 15, no. 5, 2003, pp. 323-328.
[64] Cheng, JYW et al. "Physical Activity and Erectile Dysfunction: Meta-Analysis of Population-Based Studies." Ibid. vol. 19, no. 3, 2007, pp. 245-252.
[65] Verboven, Maxim et al. "Effect of Exercise Intervention on Cardiac Function in Type 2 Diabetes Mellitus: A Systematic Review." Sports medicine, vol. 49, no. 2, 2019, pp. 255-268.
[66] Vega, Rick B et al. "Molecular Mechanisms Underlying Cardiac Adaptation to Exercise." Cell metabolism, vol. 25, no. 5, 2017, pp. 1012-1026.
[67] Olver, T Dylan et al. "Molecular Mechanisms for Exercise Training-Induced Changes in Vascular Structure and Function: Skeletal Muscle, Cardiac Muscle, and the Brain." Progress in Molecular Biology and Translational Science, vol. 135, Elsevier, 2015, pp. 227-257.
[68] Bellavere, F et al. "Effects of Aerobic or Resistance Exercise Training on Cardiovascular Autonomic Function of Subjects with Type 2 Diabetes: A Pilot Study." Nutrition, Metabolism and Cardiovascular Diseases, vol. 28, no. 3, 2018, pp. 226-233.
[69] Wu, Ne N et al. "Physical Exercise and Selective Autophagy: Benefit and Risk on Cardiovascular Health." Cells, vol. 8, no. 11, 2019, p. 1436.
[70] Thompson, Dylan et al. "Physical Activity and Exercise in the Regulation of Human Adipose Tissue Physiology." Physiological reviews, 2012.
[71] Cassidy, Sophie et al. "High-Intensity Interval Training: A Review of Its Impact on Glucose Control and Cardiometabolic Health." Diabetologia, vol. 60, no. 1, 2017, pp. 7-23.
[72] Ceylan, Asli F et al. "Cardiomyocyte-Specific Knockout of Endothelin Receptor a Attenuates Obesity Cardiomyopathy." Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, vol. 1864, no. 10, 2018, pp. 3339-3352.
[73] Wang, Cheng et al. "Aerobic Exercise Interventions Reduce Blood Pressure in Patients after Stroke or Transient Ischaemic Attack: A Systematic Review and Meta-Analysis." British journal of sports medicine, vol. 53, no. 24, 2019, pp. 1515-1525.
[74] Belardinelli, Romualdo et al. "Effects of Short-Term Moderate Exercise Training on Sexual Function in Male Patients with Chronic Stable Heart Failure." International journal of cardiology, vol. 101, no. 1, 2005, pp. 83-90.
[75] La Vignera, Sandro et al. "Aerobic Physical Activity Improves Endothelial Function in the Middle-Aged Patients with Erectile Dysfunction." The Aging Male, vol. 14, no. 4, 2011, pp. 265-272.
[76] Balducci, Stefano et al. "Anti-Inflammatory Effect of Exercise Training in Subjects with Type 2 Diabetes and the Metabolic Syndrome Is Dependent on Exercise Modalities and Independent of Weight Loss." Nutrition, Metabolism and Cardiovascular Diseases, vol. 20, no. 8, 2010, pp. 608-617.
[77] Hambrecht, Rainer et al. "Effect of Exercise on Coronary Endothelial Function in Patients with Coronary Artery Disease." New England Journal of Medicine, vol. 342, no. 7, 2000, pp. 454-460.
[78] Uematsu, MASAAKI et al. "Regulation of Endothelial Cell Nitric Oxide Synthase Mrna Expression by Shear Stress." American Journal of Physiology-Cell Physiology, vol. 269, no. 6, 1995, pp. C1371-C1378.
[79] Skrypnik, D et al. "Effect of Physical Exercise on Endothelial Function, Indicators of Inflammation and Oxidative Stress." Polski merkuriusz lekarski: organ Polskiego Towarzystwa Lekarskiego, vol. 36, no. 212, 2014, p. 117.
[80] Balligand, Jean-Luc. "Cardiac Salvage by Tweaking with Beta-3-Adrenergic Receptors." Cardiovascular research, vol. 111, no. 2, 2016, pp. 128-133.
[81] Mehanna, Emile et al. "Cardiorespiratory Fitness and Atherosclerosis: Recent Data and Future Directions." Current atherosclerosis reports, vol. 18, no. 5, 2016, p. 26.
[82] Roe, Nathan D and Jun Ren. "Nitric Oxide Synthase Uncoupling: A Therapeutic Target in Cardiovascular Diseases." Vascular pharmacology, vol. 57, no. 5-6, 2012, pp. 168-172.
[83] Kruk, Joanna et al. "Physical Exercise and Catecholamines Response: Benefits and Health Risk: Possible Mechanisms." Free Radical Research, vol. 54, no. 2-3, 2020, pp. 105-125.
[84] Brum, Patricia Chakur et al. "Exercise Training Increases Baroreceptor Gain Sensitivity in Normal and Hypertensive Rats." Hypertension, vol. 36, no. 6, 2000, pp. 1018-1022.
[85] Zinman, Bernard et al. "Physical Activity/Exercise and Diabetes." Diabetes care, vol. 27, 2004, p. S58.
[86] Thomas, Diana et al. "Exercise for Type 2 Diabetes Mellitus." Cochrane Database of Systematic Reviews, no. 3, 2006.
[87] Saki, Hossein et al. "Comparison of the Effects of Aerobic Exercise on Pulmonary Function and Levels of Inflammatory Mediators in Men with Type 2 Diabetes." International Journal of Basic Science in Medicine, vol. 2, no. 2, 2017, pp. 95-100.
[88] van Laake-Geelen, Charlotte CM et al. "The Effect of Exercise Therapy Combined with Psychological Therapy on Physical Activity and Quality of Life in Patients with Painful Diabetic Neuropathy: A Systematic Review." Scandinavian journal of pain, vol. 19, no. 3, 2019, pp. 433-439.
[89] Kluding, Patricia M et al. "The Effect of Exercise on Neuropathic Symptoms, Nerve Function, and Cutaneous Innervation in People with Diabetic Peripheral Neuropathy." Journal of Diabetes and its Complications, vol. 26, no. 5, 2012, pp. 424-429.
[90] Green, Simon et al. "Cardiovascular Control During Exercise in Type 2 Diabetes Mellitus." Journal of diabetes research, vol. 2015, 2015.
[91] Gu, Yu et al. "Aerobic Exercise Training May Improve Nerve Function in Type 2 Diabetes and Pre‐Diabetes: A Systematic Review." Diabetes/metabolism research and reviews, vol. 35, no. 2, 2019, p. e3099.
[92] Jung, Sang Hoon et al. "Aldose Reductase and Advanced Glycation Endproducts Inhibitory Effect of Phyllostachys Nigra." Biological and Pharmaceutical Bulletin, vol. 30, no. 8, 2007, pp. 1569-1572.
[93] Brownlee, M. "Banting Lecture 2004." Diabetes, vol. 54, 2005, pp. 1615-1625.
[94] Singleton, J Robinson et al. "Exercise as Therapy for Diabetic and Prediabetic Neuropathy." Current diabetes reports, vol. 15, no. 12, 2015, p. 120.
[95] Gilani, Seyed Reza Mousavi and Abdurrashid Khazaei Feizabad. "The Effects of Aerobic Exercise Training on Mental Health and Self-Esteem of Type 2 Diabetes Mellitus Patients." Health psychology research, vol. 7, no. 1, 2019.
[96] McCarthy, Olivia et al. "Resistance Isn't Futile: The Physiological Basis of the Health Effects of Resistance Exercise in Individuals with Type 1 Diabetes." Frontiers in Endocrinology, vol. 10, 2019.
[97] Cooke, Samuel et al. "Effects of Exercise, Cognitive, and Dual-Task Interventions on Cognition in Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis." PloS one, vol. 15, no. 5, 2020, p. e0232958.
[98] Van Tienen, FHJ et al. "Physical Activity Is the Key Determinant of Skeletal Muscle Mitochondrial Function in Type 2 Diabetes." The Journal of Clinical Endocrinology & Metabolism, vol. 97, no. 9, 2012, pp. 3261-3269.
[99] Phielix, Esther et al. "Exercise Training Increases Mitochondrial Content and Ex Vivo Mitochondrial Function Similarly in Patients with Type 2 Diabetes and in Control Individuals." Diabetologia, vol. 53, no. 8, 2010, pp. 1714-1721.
[100] Bloomer, Richard J and Allan H Goldfarb. "Anaerobic Exercise and Oxidative Stress: A Review." Canadian journal of applied physiology, vol. 29, no. 3, 2004, pp. 245-263.
[101] Di Meo, Sergio and Paola Venditti. "Mitochondria in Exercise-Induced Oxidative Stress." Neurosignals, vol. 10, no. 1-2, 2001, pp. 125-140.
[102] Castrogiovanni, Paola and Rosa Imbesi. "Oxidative Stress and Skeletal Muscle in Exercise." Italian journal of anatomy and embryology, vol. 117, no. 2, 2012, p. 107.
[103] Urso, Maria L and Priscilla M Clarkson. "Oxidative Stress, Exercise, and Antioxidant Supplementation." Toxicology, vol. 189, no. 1-2, 2003, pp. 41-54.
[104] Muench, John et al. "Implementing a Team-Based Sbirt Model in Primary Care Clinics." Journal of Substance Use, vol. 20, no. 2, 2015, pp. 106-112.
[105] Ramasamy, Ravichandran et al. "Receptor for Advanced Glycation Endproducts (Rage): A Formidable Force in the Pathogenesis of the Cardiovascular Complications of Diabetes & Aging." Current molecular medicine, vol. 7, no. 8, 2007, pp. 699-710.
[106] Magalhães, Pedro M et al. "Involvement of Advanced Glycation End Products in the Pathogenesis of Diabetic Complications: The Protective Role of Regular Physical Activity." European Review of Aging and Physical Activity, vol. 5, no. 1, 2008, pp. 17-29.
[107] Radoi, VALENTIN et al. "Advanced Glycation End Products in Diabetes Mellitus: Mechanism of Action and Focused Treatment." Proceedings of the Romanian Academy, Series B, vol. 1, 2012, pp. 9-19.
[108] Boor, Peter et al. "Regular Moderate Exercise Reduces Advanced Glycation and Ameliorates Early Diabetic Nephropathy in Obese Zucker Rats." Metabolism, vol. 58, no. 11, 2009, pp. 1669-1677.
[109] Sehn, Luiz Fernado Biazus et al. "Effects of Physical Exercise on Cognitive Function of Older Adults with Mild Cognitive Impairment: A Systematic Review and Meta-Analysis." Archives of Gerontology and Geriatrics, 2020, p. 104048.
[110] Wu, Zhi-Jian et al. "The Impact of Interval Training on Cardiorespiratory Fitness, Body Composition, Physical Fitness, and Metabolic Parameters in Older Adults: A Systematic Review and Meta-Analysis." 2020.
[111] Willoughby, DARRYN S and LEMUEL Taylor. "Effects of Sequential Bouts of Resistance Exercise on Androgen Receptor Expression." Medicine and science in sports and exercise, vol. 36, no. 9, 2004, pp. 1499-1506.
[112] Kraemer, William J et al. "Acute Hormonal Responses to Heavy Resistance Exercise in Younger and Older Men." European journal of applied physiology and occupational physiology, vol. 77, no. 3, 1998, pp. 206-211.
[113] Herbst, Karen L and Shalender Bhasin. "Testosterone Action on Skeletal Muscle." Current Opinion in Clinical Nutrition & Metabolic Care, vol. 7, no. 3, 2004, pp. 271-277.
[114] Kraemer, William J and Nicholas A Ratamess. "Hormonal Responses and Adaptations to Resistance Exercise and Training." Sports medicine, vol. 35, no. 4, 2005, pp. 339-361.
[115] Baker, Jeremy R et al. "Effects of Age on Testosterone Responses to Resistance Exercise and Musculoskeletal Variables in Men." Journal of Strength and Conditioning Research, vol. 20, no. 4, 2006, p. 874.
[116] Izquierdo, M et al. "Effects of Strength Training on Muscle Power and Serum Hormones in Middle-Aged and Older Men." Journal of applied physiology, vol. 90, no. 4, 2001, pp. 1497-1507.
[117] Nicklas, BJ et al. "Testosterone, Growth Hormone and Igf-I Responses to Acute and Chronic Resistive Exercise in Men Aged 55-70 Years." International journal of sports medicine, vol. 16, no. 07, 1995, pp. 445-450.
[118] Hawkins, Vivian N et al. "Effect of Exercise on Serum Sex Hormones in Men: A 12-Month Randomized Clinical Trial." Medicine and science in sports and exercise, vol. 40, no. 2, 2008, p. 223.
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    Anees Alyafei. (2020). Effect of Regular Physical Exercise on the Progression of Erectile Dysfunction Among Male Patients with Diabetes Mellitus. Clinical Medicine Research, 9(4), 74-84. https://doi.org/10.11648/j.cmr.20200904.12

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    Anees Alyafei. Effect of Regular Physical Exercise on the Progression of Erectile Dysfunction Among Male Patients with Diabetes Mellitus. Clin. Med. Res. 2020, 9(4), 74-84. doi: 10.11648/j.cmr.20200904.12

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    AMA Style

    Anees Alyafei. Effect of Regular Physical Exercise on the Progression of Erectile Dysfunction Among Male Patients with Diabetes Mellitus. Clin Med Res. 2020;9(4):74-84. doi: 10.11648/j.cmr.20200904.12

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  • @article{10.11648/j.cmr.20200904.12,
      author = {Anees Alyafei},
      title = {Effect of Regular Physical Exercise on the Progression of Erectile Dysfunction Among Male Patients with Diabetes Mellitus},
      journal = {Clinical Medicine Research},
      volume = {9},
      number = {4},
      pages = {74-84},
      doi = {10.11648/j.cmr.20200904.12},
      url = {https://doi.org/10.11648/j.cmr.20200904.12},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.cmr.20200904.12},
      abstract = {There is no agreed management for Erectile Dysfunction (ED) for male patients with Diabetes Mellitus (DM). Regular Physical Exercise (PE) starts to be a more exciting area that needs further focus. This review attempts to gather available data about the ED burden, etiology, risk factors, assessment, and management. Further, it highlights the available evidence on the effect of PE on the progression of ED and the possible underline mechanisms. The available evidence is hugely supportive of the beneficial role of PE in the ED. The cardiovascular, neurological, endothelial, metabolic, and overall health benefits of PE are repeated mechanisms reported by many researchers. The possible explanation is quite not clear due to the complexity and bidirectional effect on many aspects related to the changes during PE. Further interventional studies are needed to determine the superiority of each factor. All physicians managing DM and ED are strongly invited to involve PE as part of their management plan in conjunction with other available treatment options. Research has to look after which type, duration, frequency, and intensity of PE is sufficient for detectable improvement in ED.},
     year = {2020}
    }
    

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    SN  - 2326-9057
    UR  - https://doi.org/10.11648/j.cmr.20200904.12
    AB  - There is no agreed management for Erectile Dysfunction (ED) for male patients with Diabetes Mellitus (DM). Regular Physical Exercise (PE) starts to be a more exciting area that needs further focus. This review attempts to gather available data about the ED burden, etiology, risk factors, assessment, and management. Further, it highlights the available evidence on the effect of PE on the progression of ED and the possible underline mechanisms. The available evidence is hugely supportive of the beneficial role of PE in the ED. The cardiovascular, neurological, endothelial, metabolic, and overall health benefits of PE are repeated mechanisms reported by many researchers. The possible explanation is quite not clear due to the complexity and bidirectional effect on many aspects related to the changes during PE. Further interventional studies are needed to determine the superiority of each factor. All physicians managing DM and ED are strongly invited to involve PE as part of their management plan in conjunction with other available treatment options. Research has to look after which type, duration, frequency, and intensity of PE is sufficient for detectable improvement in ED.
    VL  - 9
    IS  - 4
    ER  - 

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Author Information
  • Preventive Medicine, Primary Health Care Corporation, Doha, Qatar

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