Natural killer T Cells: A Powerful Via in the Regulation of Non Communicable Chronic Diseases

Carlos Ramirez-Velazquez; Juan Carlos Paredes-Palma; Sandra Vanesa Patzi-Vargas

doi:doi:10.11648/j.cmr.20190806.12

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Natural killer T Cells: A Powerful Via in the Regulation of Non Communicable Chronic Diseases

Carlos Ramirez-Velazquez, Juan Carlos Paredes-Palma, Sandra Vanesa Patzi-Vargas

Published in Clinical Medicine Research (Volume 8, Issue 6)

Received: 13 October 2019 Accepted: 12 November 2019 Published: 17 December 2019

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Abstract

The Natural Killer T cells (NKT) constitute a population of T lymphocytes that co-express an antigen receptor (TCR) and a marker of natural killer cells (NK1.1). We have found that after stimulation through TCR, the NKT cells secrete various cytokines that play an important role in the innate immune response and have a fundamental participation in the initial stages of the immune response to many pathogens and tumours. NKT cells belong to a group of autoreactive T cells that are generated in the thymus, which is why they have been found to play an important role in the regulation of different autoimmune diseases, such as type 1 diabetes, systemic lupus erythematosus, multiple sclerosis, and others. Also, in adulthood there is an aging of the immune system known as immunosenescence, where a decrease and alteration of the function of NKT cells has been observed, which leads to a greater oncological, viral and autoimmune diseases. It has also recently been found that these cells participate in bronchial inflammation in patients with allergic asthma as well as in rhinitis and atopic dermatitis; having these cells a clear role in the regulation of various diseases and that has not been studied as a therapeutic target.

Published in	Clinical Medicine Research (Volume 8, Issue 6) This article belongs to the Special Issue Globalization and Advances on Non-Communicable Chronic Diseases
DOI	10.11648/j.cmr.20190806.12
Page(s)	137-143
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2019. Published by Science Publishing Group

Keywords

Natural Killer T Cells, Autoimmune Diseases, Immune System Diseases

References

[1]	Bendelac A, Bonneville M, Kearney JF. Autorreactivity by desing: innate B and T lymphocytes. Nature Rev Immunol 2001; 1 (3): 177-86.
[2]	Torina A, Guggino G, La Manna MP, Sireci G. The Janus Face of NKT Cell Function in Autoimmunity and Infectious Diseases. Int J Mol Sci. 2018; 19 (2): 1-10.
[3]	Krijgsman D, Hokland M, Kuppen PJK. The Role of Natural Killer T Cells in Cancer-A Phenotypical and Functional Approach. Front Immunol 2018; 9 (367): 1-21.
[4]	Sonoda KH, Exley M, Snapper S, Balk SP, Stein-Streilein J. Cd1- reactive natural killer T cells are required for development of systemic tolerance through an immune-privileged site. J Exp med 1999; 190 (9): 1215-26.
[5]	Patiño-Lopez G, Hevezi P, Lee J, Willhite D, Verge GM, Lechner SM, et al. Human class-I restricted T cell associated molecule is highly expressed in the cerebellum and is a marker for activated NKT and CD8+ T lymphocytes. J Neuroimmunology 2006; 171 (1-2): 145-55.
[6]	Aleksandar KS, Jang JP, Joyce S. Innate self recognition by an invariant, rearreged T cell receptor and its immune consequences. Immunology 2003; 109 (2): 171-84.
[7]	Godfrey DI, Hammond KJ, Poulton LD, Smyth MJ, Baxter AG. NKT cells: facts, functions and fallacies. Immunol Today 2000; 21 (11): 573-83.
[8]	Akbari O, Faul JL, Hoyte EG, Berry GJ, Wahlström J, Kronenberg M, et al. CD4+ invariant T-cell-receptor+ natural killer T cell in bronchial asthma. N Engl Med 2006; 354 (11): 1117-29.
[9]	Beristain-Covarrubias N, Canche-Pool EB, Ramirez-Velazquez C, Barragan-Galvez JC, Gomez-Diaz RA, Ortiz-Navarrete V. Class I-Restricted T Cell-Associated Molecule Is a Marker for IFN-γ-Producing iNKT Cells in Healthy Subjects and Patients with Type 1 Diabetes. J Interferon Cytokine Res 2017; 37 (1): 39-49.
[10]	Hammond KJ, Godfrey DI. NKT cells: potential targets for autoimmune disease therapy? Tissue Antigens 2002; 59 (5): 353-63.
[11]	Godfrey D. I, Kronenberg M. Going both ways: immune regulation via CD1d-dependent NKT cells. J. Clin. Invest. 2004; 114 (10): 1379–1388.
[12]	Baxter AG, Kinder SJ, Hammond KJL, Scollay R, Godfrey DI. Association Between αβTCR+ CD4–CD8–T-Cell deficiency and IDDM in NOD/Lt mice. Diabetes 1997; 46 (4): 572–82.
[13]	Godfrey DI, Kinder SJ, Silvera P, Baxter AG. Flow cytometric study of T cell development in NOD mice reveals a deficiency in TCR+ CD4–CD8– thymocytes. J Autoimmunity 1997; 10 (3): 279–85.
[14]	Gombert JM, Herbelin A, Tancredebohin E, Dy M, Carnaud C, Bach JF. Early quantitative and functional deficiency of NK1+ -like thymocytes in the NOD mouse. Eur J Immunol 1996; 26 (12): 2989–98.
[15]	Hammond KJ, Pellicci DG, Poulton LD, Naidenko OV, Scalzo AA, Baxter AG, et al. CD1d- resticted NKT cells: an interstrain comparison. J Immunol 2001; 167 (3): 1164-1173.
[16]	Poulton LD, Smyth MJ, Hawke CG, Silvera P, Shepherd D, Naidenko OV, et al. Cytometric and functional analyses of NK and NKT cell deficiencies in NOD mice. Int Immunol 2001; 13 (7): 887-896.
[17]	Hong S, Wilson MT, Serizawa I, Wu L, Singh N, Naidenko OV, et al. The natural killer T-cell ligand -galactosylceramide prevents autoimmune diabetes in non-obese diabetic mice. Nat Med 2001; 7 (9): 1052-1056.
[18]	Matsuki N, Stanic AK, Embers ME, Van Kaer L, Morel L, Joyce S. Genetic dissection of Vα14Jα18 natural T cell number and funtion in autoimmune-prone mice. J Immunol 2003; 170 (11): 5429-5437.
[19]	Lehuen A, Lantz O, Beaudoin L, Laloux V, Carnaud C, Bendelac A, et al. Overexpression of natural killer T cells protects Va14-Ja281 transgenic nonobese diabetic mice against diabetes. J Exp Med 1998; 188 (10): 1831-1839.
[20]	Hammond KJL, Poulton LD, Palmisano LJ, Silveira PA, Godfrey DI, Baxter AG. -T cell receptor (TCR)+ CD4- CD8- (NKT) thymocytes prevent insulin-dependent diabetes mellitus in nonobese diabetic (NOD)/Lt mice by the influence of interleukin (IL)-4 and/or IL-10. J Exp Med 1998; 187 (7): 1047-1056.
[21]	Wang B, Geng YB, Wang CR. CD1-restricted NKT cells protect nonobese diabetic mice from developing diabetes. J Exp Med 2001; 194 (3): 313-320.
[22]	Sharif S, Arreaza GA, Zucker P, Mi Qs, Sondhi J, Naidenko OV, et al. Activation of natural killer T cells by -galactosylceramide treatment prevents the onset and recurrence of autoimmune type 1 diabetes. Nat Med 2001; 7 (9): 1057-1062.
[23]	Wilson SB, Kent SC, Horton HF, Hill AA, Bollyky PL, Hafler DA, et al. Multiple differences in gene expression in regulatory V24JQ T cells from identical twins discordant for type 1 diabetes. Proc Natl Acad Sci USA 2000; 97 (13): 7411-7416.
[24]	Owens T, Wekerle H, Antel J. Genetic models for CNS inflammation. Nat Med 2001; 7 (2): 161–6.
[25]	Pal E, Tabira T, Kawano T, Taniguchi M, Miyake S, Yamamura T. Costimulation dependent modulation of experimental autoimmune encephalomyelitis by ligand stimulation of Vα14 NK T cells. J Immunol 2001; 166 (1): 662–8.
[26]	Miyamoto K, Miyake S, Yamamura T. Asynthetic glycolipid prevents autoimmune encephalomyelitis by inducing TH2 bias of natural killer T cells. Nature 2001; 413 (6855): 531–4.
[27]	Singh AK, Wilson MT, Hong S, Olivares-Villagómez D, Du C, Stanic AK, et al. Natural killer T cell activation protects mice against experimental autoimmune encephalomyelitis. J Exp Med 2001; 194 (12): 1801–11.
[28]	Jahng AW, Maricic I, Pedersen B, Burdin N, Naidenko O, Kronenberg M, et al. Activation of natural killer T cells potentiates or prevents experimental autoimmune encephalomyelitis. J Exp Med 2001; 194 (12): 1789–99.
[29]	Kojo S, Adachi Y, Keino H, Taniguchi M, Sumida T. Dysfunction of T cell receptor AV24AJ18+, BV11+ double-negative regulatory natural killer T cells in autoimmune diseases. Arthritis Rheum 2001; 44 (5): 1127–38.
[30]	Sumida T, Sakamoto A, Murata H, Makino Y, Takahashi H, Yoshida S, et al. Selective reduction of T cells bearing invariant Va24JaQ antigen receptor in patients with systemic sclerosis. J Exp Med1995; 182 (4): 1163–8.
[31]	van der Vliet HJ, von Blomberg BM, Nishi N, Reijm M, Voskuyl AE, van Bodegraven AA, et al. Circulating Vα24+ Vβ11+ NKT cell numbers are decreased in a wide variety of diseases that are characterized by autoreactive tissue damage. Clin Immunol 2001; 100 (2): 144–8.
[32]	Illes Z, Kondo T, Newcombe J, Oka N, Tabira T, Yamamura T. Differential expression of NK T cell V24JQ invariant TCR chain in the lesions of multiple sclerosis and chronic inflammatory demyelinating poly neuropathy. J Immunol 2000; 164 (8): 4375–81.
[33]	Gausling R, Trollmo C, Hafler DA. Decreases in interleukin-4 secretion by invariant CD4–CD8–V24JQ T cells in peripheral blood of patients with relapsing-remitting multiple sclerosis. Clin Immunol 2001; 98 (1): 11-7.
[34]	Yanagihara Y, Shiozawa K, Takai M, Kyogoku M, Shiozawa S. Natural killer (NK) T cells are significantly decreased in the peripheral blood of patients with rheumatoid arthritis (RA). Clin Exp Immunol 1999; 118 (1): 131–6.
[35]	Maeda T, Keino H, Asahara H, Taniguchi M, Nishioka K, Sumida T. Decreased TCR AV24AJ18+ double-negative T cells in rheumatoid synovium. Rheumatology (Oxford) 1999; 38 (2): 186–8.
[36]	Osman Y, Kawamura T, Naito T, Takeda K, Van Kaer L, Okumura K, et al. Activation of hepatic NKT cells and subsequent liver injury following administration of alpha-galactosylceramide. Eur J Immunol 2000; 30 (7): 1919–28.
[37]	Pawelec G, Effros RB, Carusco C, Remarque E, et al. T cells and aging (update february 1999) Front Biosci. 1999; 4: 216-69.
[38]	Pawelec G, Solana R, Remarque E, Mariani E. Impact of aging on innate immunity. J Leukoc Biol. 1998; 64 (6): 703-12.
[39]	Mocchegiani E, Giacconi R, Muti E, Muzzioli M, Cipriano C. Plasticity of neuroendocrine-thymus interactions during ontogeny and ageing: role of zinc and arginine. Ageing Res Rev. 2006; 5 (3): 281-309.
[40]	Emoto M, Kaufmann SH. Liver NKT cells: an account of heterogeneity. Trends Immunol 2003; 24 (7): 364–69.
[41]	DelaRosa O, Tarazona R, Casado JG, Alonso C, Ostos B, Peña J, et al. V 24+ NKT cells are decreased in elderly humans. Experimental Gerontology 2002; 37 (2): 213-17.
[42]	Abo T, Kawamura T, Watanabe H. Physiological responses of extrathymic T cells in the liver. Immunol 2000; 174: 135–49.
[43]	Watanabe H, Miyaji C, Seki S, Abo T. c-kit+ stem cells and thymocyte precursors in the livers of adult mice. J. Exp. Med. 1996; 184 (2): 687–93.
[44]	Emoto M, Miyamoto M, Emoto Y, Zerrahn J, Kaufmann SH. A critical role of T-cell receptor gamma/delta cells in antibacterial protection in mice early in life. Hepatology. 2001; 33 (4): 887–93.
[45]	Colonna-Romano G, Potestio M, Aquino A, Candore G, Lio D, Caruso C. Gamma/delta T lymphocytes are affected in the elderly. Exp. Gerontol. 2002; 37 (2-3): 205–11.
[46]	Mocchegiani E, Giacconi R, Cipriano C, Gasparini N, Bernardini G, Malavolta M, et al. The variations during the circadian cycle of liver CD1d unrestricted NK1.1+TCRγδ+ cells lead to successful aging. Role of metallothioneins/IL-6/gp130/PARP-1 interplay in very old mice. Exp. Gerontol. 2004; 39 (5): 775–88.
[47]	Umetsu DT, Dekruyff RH. Immune dysregulation in asthma. Current Opinion in Immunology 2006; 18 (6): 727-732.
[48]	Elkhal A, Pichavant M, He R, Scott J, Meyer E, Goya S, et al. CD1d restricted natural killer T cells are not required for allergic skin inflammation. J Allergy Clin Immunol 2006; 118 (6): 1363-8.
[49]	Ronger-Savle S, Valladeau J, Claudy A, Schmitt D, Peguet-Navarro J, Dezutter-Dambuyant C, et al. TGF Inhibits CD1d Expression on Dendritic Cells. J Invest Dermatol 2005; 124 (1): 116–118.
[50]	Hamzaoui A, Cheik Rouhou S, Graïri H, Abid H, Ammar J, Chelbi H, et al. NKT cells in the induced sputum of severe asthmatics. Mediators of Inflammation 2006; 2006 (2): 71214.
[51]	Umetsu DT, De Kruyff RH. A role for natural killer T cells in asthma. Nature Reviews Immunology 2006; 6 (12): 953-958.
[52]	Amano M, Baumgarth N, Dick MD, Brossay L, Kronenberg M, Herzenberg LA, et al. CD1 expression defines subsets of follicular and marginal zone B cells in the spleen: β2-microglobulin-dependent and independent forms. J. Immunol. 1998; 161 (4): 1710–1717.
[53]	Adcock IM, Ito K. Steroid resistance in asthma: a major problem requiring novel solutions or a nonissue? Curr. Opin. Pharmacol. 2004; 4 (3): 257–262.
[54]	Ito K, Chung KF, Adcock IM. Update on glucocorticoid action and resistance. J. Allergy Clin. Immunol. 2006; 117 (3): 522–543.
[55]	Agea E, Russano A, Bistoni O, Mannucci R, Nicoletti I, Corazzi L, et al. Human CD1-restricted T cell recognition of lipids from pollens. J. Exp. Med. 2005; 202 (2): 295–308.
[56]	Berry MA, Hargadon B, Shelley M, Parker D, Shaw DE, Green RH, et al. Evidence of a role of tumor necrosis factor alpha in refractory asthma. N Engl J Med. 2006; 354 (7): 697-708.
[57]	Akbari O, Stock P, Meyer E, Kronenberg M, Sidobre S, Nakayama T, et al. Essential role of NKT cells producing IL4 and IL13 in the development of allergen-induced airway hyperreactivity. Nat Med. 2003; 9 (5): 582-588.
[58]	Bahceciler NN, Arikan C, Taylor A, Akdis M, Blazer k, Barlan IB, et al. Impact of sublingual immunotherapy on specific antibody levels in asthmatic children allergic to house dust mites. Int Arch Allergy Immunol. 2005; 136 (3): 287-294.
[59]	Godfrey DI, Kronenberg M. Going both ways: Immune regulation via CD1d-dependent NKT cells. J. Clin. Invest. 2004; 114 (10): 1379–1388.
[60]	Taniguchi M, Harada M, Kojo S, Nakayama T, Wakao H. The regulatory role of Vα14 NKT cells in innate and acquired immune response. Annu. Rev. Immunol. 2003; 21: 483–513.
[61]	Exley MA, Koziel MJ. To be or not to be NKT: natural killer T cells in the liver. Hepatoloy 2004; 40 (5): 1033–1040.
[62]	Seino K, Taniguchi M. Functionally distinct NKT cell subsets and subtypes. J. Exp. Med. 2005; 202 (12): 1623–1626.
[63]	Kay AB. Natural Killer T Cells and Asthma. N Engl J Med. 2006; 354 (11): 1186-1188.
[64]	Carpio-Pedroza JC, Vaughan G, del Rio-Navarro BE, del Río-Chivardí JM, Vergara-Castañeda A, Jiménez-Zamudio LA, et al. Participation of CD161 (+) and invariant natural killer T cells in pediatric asthma exacerbations. Allergy Asthma Proc. 2013; 34 (1): 84-92.

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Carlos Ramirez-Velazquez, Juan Carlos Paredes-Palma, Sandra Vanesa Patzi-Vargas. (2019). Natural killer T Cells: A Powerful Via in the Regulation of Non Communicable Chronic Diseases. Clinical Medicine Research, 8(6), 137-143. https://doi.org/10.11648/j.cmr.20190806.12

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ACS Style

Carlos Ramirez-Velazquez; Juan Carlos Paredes-Palma; Sandra Vanesa Patzi-Vargas. Natural killer T Cells: A Powerful Via in the Regulation of Non Communicable Chronic Diseases. Clin. Med. Res. 2019, 8(6), 137-143. doi: 10.11648/j.cmr.20190806.12

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AMA Style

Carlos Ramirez-Velazquez, Juan Carlos Paredes-Palma, Sandra Vanesa Patzi-Vargas. Natural killer T Cells: A Powerful Via in the Regulation of Non Communicable Chronic Diseases. Clin Med Res. 2019;8(6):137-143. doi: 10.11648/j.cmr.20190806.12

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@article{10.11648/j.cmr.20190806.12,
  author = {Carlos Ramirez-Velazquez and Juan Carlos Paredes-Palma and Sandra Vanesa Patzi-Vargas},
  title = {Natural killer T Cells: A Powerful Via in the Regulation of Non Communicable Chronic Diseases},
  journal = {Clinical Medicine Research},
  volume = {8},
  number = {6},
  pages = {137-143},
  doi = {10.11648/j.cmr.20190806.12},
  url = {https://doi.org/10.11648/j.cmr.20190806.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.cmr.20190806.12},
  abstract = {The Natural Killer T cells (NKT) constitute a population of T lymphocytes that co-express an antigen receptor (TCR) and a marker of natural killer cells (NK1.1). We have found that after stimulation through TCR, the NKT cells secrete various cytokines that play an important role in the innate immune response and have a fundamental participation in the initial stages of the immune response to many pathogens and tumours. NKT cells belong to a group of autoreactive T cells that are generated in the thymus, which is why they have been found to play an important role in the regulation of different autoimmune diseases, such as type 1 diabetes, systemic lupus erythematosus, multiple sclerosis, and others. Also, in adulthood there is an aging of the immune system known as immunosenescence, where a decrease and alteration of the function of NKT cells has been observed, which leads to a greater oncological, viral and autoimmune diseases. It has also recently been found that these cells participate in bronchial inflammation in patients with allergic asthma as well as in rhinitis and atopic dermatitis; having these cells a clear role in the regulation of various diseases and that has not been studied as a therapeutic target.},
 year = {2019}
}

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TY  - JOUR
T1  - Natural killer T Cells: A Powerful Via in the Regulation of Non Communicable Chronic Diseases
AU  - Carlos Ramirez-Velazquez
AU  - Juan Carlos Paredes-Palma
AU  - Sandra Vanesa Patzi-Vargas
Y1  - 2019/12/17
PY  - 2019
N1  - https://doi.org/10.11648/j.cmr.20190806.12
DO  - 10.11648/j.cmr.20190806.12
T2  - Clinical Medicine Research
JF  - Clinical Medicine Research
JO  - Clinical Medicine Research
SP  - 137
EP  - 143
PB  - Science Publishing Group
SN  - 2326-9057
UR  - https://doi.org/10.11648/j.cmr.20190806.12
AB  - The Natural Killer T cells (NKT) constitute a population of T lymphocytes that co-express an antigen receptor (TCR) and a marker of natural killer cells (NK1.1). We have found that after stimulation through TCR, the NKT cells secrete various cytokines that play an important role in the innate immune response and have a fundamental participation in the initial stages of the immune response to many pathogens and tumours. NKT cells belong to a group of autoreactive T cells that are generated in the thymus, which is why they have been found to play an important role in the regulation of different autoimmune diseases, such as type 1 diabetes, systemic lupus erythematosus, multiple sclerosis, and others. Also, in adulthood there is an aging of the immune system known as immunosenescence, where a decrease and alteration of the function of NKT cells has been observed, which leads to a greater oncological, viral and autoimmune diseases. It has also recently been found that these cells participate in bronchial inflammation in patients with allergic asthma as well as in rhinitis and atopic dermatitis; having these cells a clear role in the regulation of various diseases and that has not been studied as a therapeutic target.
VL  - 8
IS  - 6
ER  -

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Author Information

Carlos Ramirez-Velazquez

Allergy Service of the General Hospital “Fernando Quiroz Gutierrez”, Institute of Security and Social Services of State Workers, Mexico City, Mexico
Juan Carlos Paredes-Palma

Internal Medicine Service of the General Hospital “Fernando Quiroz Gutierrez”, Institute of Security and Social Services of State Workers, Mexico City, Mexico
Sandra Vanesa Patzi-Vargas

Department of Biostatistics and Epidemiology, Center for Research and Continuing Education (CENINVEC), Nezahualcoyotl City, Mexico

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APA Style

Carlos Ramirez-Velazquez, Juan Carlos Paredes-Palma, Sandra Vanesa Patzi-Vargas. (2019). Natural killer T Cells: A Powerful Via in the Regulation of Non Communicable Chronic Diseases. Clinical Medicine Research, 8(6), 137-143. https://doi.org/10.11648/j.cmr.20190806.12

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ACS Style

Carlos Ramirez-Velazquez; Juan Carlos Paredes-Palma; Sandra Vanesa Patzi-Vargas. Natural killer T Cells: A Powerful Via in the Regulation of Non Communicable Chronic Diseases. Clin. Med. Res. 2019, 8(6), 137-143. doi: 10.11648/j.cmr.20190806.12

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AMA Style

Carlos Ramirez-Velazquez, Juan Carlos Paredes-Palma, Sandra Vanesa Patzi-Vargas. Natural killer T Cells: A Powerful Via in the Regulation of Non Communicable Chronic Diseases. Clin Med Res. 2019;8(6):137-143. doi: 10.11648/j.cmr.20190806.12

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@article{10.11648/j.cmr.20190806.12,
  author = {Carlos Ramirez-Velazquez and Juan Carlos Paredes-Palma and Sandra Vanesa Patzi-Vargas},
  title = {Natural killer T Cells: A Powerful Via in the Regulation of Non Communicable Chronic Diseases},
  journal = {Clinical Medicine Research},
  volume = {8},
  number = {6},
  pages = {137-143},
  doi = {10.11648/j.cmr.20190806.12},
  url = {https://doi.org/10.11648/j.cmr.20190806.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.cmr.20190806.12},
  abstract = {The Natural Killer T cells (NKT) constitute a population of T lymphocytes that co-express an antigen receptor (TCR) and a marker of natural killer cells (NK1.1). We have found that after stimulation through TCR, the NKT cells secrete various cytokines that play an important role in the innate immune response and have a fundamental participation in the initial stages of the immune response to many pathogens and tumours. NKT cells belong to a group of autoreactive T cells that are generated in the thymus, which is why they have been found to play an important role in the regulation of different autoimmune diseases, such as type 1 diabetes, systemic lupus erythematosus, multiple sclerosis, and others. Also, in adulthood there is an aging of the immune system known as immunosenescence, where a decrease and alteration of the function of NKT cells has been observed, which leads to a greater oncological, viral and autoimmune diseases. It has also recently been found that these cells participate in bronchial inflammation in patients with allergic asthma as well as in rhinitis and atopic dermatitis; having these cells a clear role in the regulation of various diseases and that has not been studied as a therapeutic target.},
 year = {2019}
}

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TY  - JOUR
T1  - Natural killer T Cells: A Powerful Via in the Regulation of Non Communicable Chronic Diseases
AU  - Carlos Ramirez-Velazquez
AU  - Juan Carlos Paredes-Palma
AU  - Sandra Vanesa Patzi-Vargas
Y1  - 2019/12/17
PY  - 2019
N1  - https://doi.org/10.11648/j.cmr.20190806.12
DO  - 10.11648/j.cmr.20190806.12
T2  - Clinical Medicine Research
JF  - Clinical Medicine Research
JO  - Clinical Medicine Research
SP  - 137
EP  - 143
PB  - Science Publishing Group
SN  - 2326-9057
UR  - https://doi.org/10.11648/j.cmr.20190806.12
AB  - The Natural Killer T cells (NKT) constitute a population of T lymphocytes that co-express an antigen receptor (TCR) and a marker of natural killer cells (NK1.1). We have found that after stimulation through TCR, the NKT cells secrete various cytokines that play an important role in the innate immune response and have a fundamental participation in the initial stages of the immune response to many pathogens and tumours. NKT cells belong to a group of autoreactive T cells that are generated in the thymus, which is why they have been found to play an important role in the regulation of different autoimmune diseases, such as type 1 diabetes, systemic lupus erythematosus, multiple sclerosis, and others. Also, in adulthood there is an aging of the immune system known as immunosenescence, where a decrease and alteration of the function of NKT cells has been observed, which leads to a greater oncological, viral and autoimmune diseases. It has also recently been found that these cells participate in bronchial inflammation in patients with allergic asthma as well as in rhinitis and atopic dermatitis; having these cells a clear role in the regulation of various diseases and that has not been studied as a therapeutic target.
VL  - 8
IS  - 6
ER  -

Copy | Download