There has been a limited evaluation of the efficacy of administered vitamin-D3 and bisphosphonate in a single pill (once-weekly) on changes of Bone Mineral Density (BMD), speciality in elderly people. To evaluate the changes in BMD, using Risedronate and vitamin D3, in patients from the first level of primary care after a period of more than 2 years of follow-up. An observational and retrospective cohort study, in a non-controlled, real-life setting nested to a database was designed. Records of participants between March-04-2008 and June-27-2012. Mexican patients from 21 Clinics of Family Medicine. The database is characterized by all patients received Risedronate (35 mg) and vitamin-D3 (2800 IU) combined in a single pill, administered once-weekly. BMD was determined in the distal portion of the radius bone using an Omnisense-7000S bone densitometer. The Kaplan-Meier method was used to estimate cumulative probabilities. Hazard ratios (HRs) were estimated using Cox-proportional hazard-models. A total of 14,721 women were included. The mean time of treatment was 27.06 months (interquartile-range=26.00-29.00); the crude HR in patients with osteoporosis was 2.483 (95%CI 1.806-3.414) times higher than their counterparts with osteopenia. In relation to age, the increase in BMD was 26% higher (HR=0.739; 95%CI 0.712-0.766) in patients with 60 or more age than their counterparts aged ≤59 years. The duration of treatment with risedronate/vitamin D3 once-weekly depends on the target population and need strict monitoring of BMD particularly for those patients who have a treatment for more of 18 months due to the risk of decreased BMD.
| Published in |
Clinical Medicine Research (Volume 8, Issue 5)
This article belongs to the Special Issue Globalization and Advances on Non-Communicable Chronic Diseases |
| DOI | 10.11648/j.cmr.20190805.11 |
| Page(s) | 93-100 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2019. Published by Science Publishing Group |
Risedronate (35 mg) and Vitamin D3 (2800 IU), Retrospective Cohort Study, Bone Mineral Density, Cox Proportional Hazard Models
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APA Style
Daniel Lopez-Hernandez, Nadhyieli Orozco-Campos, Leticia Brito-Aranda, Maria de la Luz Lopez-Hernandez, Aurora Bautista-Marquez, et al. (2019). Efficacy of Risedronate and Vitamin D3 Once-weekly on Bone Mineral Density in Women Patients with Osteoporosis. Clinical Medicine Research, 8(5), 93-100. https://doi.org/10.11648/j.cmr.20190805.11
ACS Style
Daniel Lopez-Hernandez; Nadhyieli Orozco-Campos; Leticia Brito-Aranda; Maria de la Luz Lopez-Hernandez; Aurora Bautista-Marquez, et al. Efficacy of Risedronate and Vitamin D3 Once-weekly on Bone Mineral Density in Women Patients with Osteoporosis. Clin. Med. Res. 2019, 8(5), 93-100. doi: 10.11648/j.cmr.20190805.11
AMA Style
Daniel Lopez-Hernandez, Nadhyieli Orozco-Campos, Leticia Brito-Aranda, Maria de la Luz Lopez-Hernandez, Aurora Bautista-Marquez, et al. Efficacy of Risedronate and Vitamin D3 Once-weekly on Bone Mineral Density in Women Patients with Osteoporosis. Clin Med Res. 2019;8(5):93-100. doi: 10.11648/j.cmr.20190805.11
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Download@article{10.11648/j.cmr.20190805.11,
author = {Daniel Lopez-Hernandez and Nadhyieli Orozco-Campos and Leticia Brito-Aranda and Maria de la Luz Lopez-Hernandez and Aurora Bautista-Marquez and Vesta Richardson},
title = {Efficacy of Risedronate and Vitamin D3 Once-weekly on Bone Mineral Density in Women Patients with Osteoporosis},
journal = {Clinical Medicine Research},
volume = {8},
number = {5},
pages = {93-100},
doi = {10.11648/j.cmr.20190805.11},
url = {https://doi.org/10.11648/j.cmr.20190805.11},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.cmr.20190805.11},
abstract = {There has been a limited evaluation of the efficacy of administered vitamin-D3 and bisphosphonate in a single pill (once-weekly) on changes of Bone Mineral Density (BMD), speciality in elderly people. To evaluate the changes in BMD, using Risedronate and vitamin D3, in patients from the first level of primary care after a period of more than 2 years of follow-up. An observational and retrospective cohort study, in a non-controlled, real-life setting nested to a database was designed. Records of participants between March-04-2008 and June-27-2012. Mexican patients from 21 Clinics of Family Medicine. The database is characterized by all patients received Risedronate (35 mg) and vitamin-D3 (2800 IU) combined in a single pill, administered once-weekly. BMD was determined in the distal portion of the radius bone using an Omnisense-7000S bone densitometer. The Kaplan-Meier method was used to estimate cumulative probabilities. Hazard ratios (HRs) were estimated using Cox-proportional hazard-models. A total of 14,721 women were included. The mean time of treatment was 27.06 months (interquartile-range=26.00-29.00); the crude HR in patients with osteoporosis was 2.483 (95%CI 1.806-3.414) times higher than their counterparts with osteopenia. In relation to age, the increase in BMD was 26% higher (HR=0.739; 95%CI 0.712-0.766) in patients with 60 or more age than their counterparts aged ≤59 years. The duration of treatment with risedronate/vitamin D3 once-weekly depends on the target population and need strict monitoring of BMD particularly for those patients who have a treatment for more of 18 months due to the risk of decreased BMD.},
year = {2019}
}
TY - JOUR T1 - Efficacy of Risedronate and Vitamin D3 Once-weekly on Bone Mineral Density in Women Patients with Osteoporosis AU - Daniel Lopez-Hernandez AU - Nadhyieli Orozco-Campos AU - Leticia Brito-Aranda AU - Maria de la Luz Lopez-Hernandez AU - Aurora Bautista-Marquez AU - Vesta Richardson Y1 - 2019/09/30 PY - 2019 N1 - https://doi.org/10.11648/j.cmr.20190805.11 DO - 10.11648/j.cmr.20190805.11 T2 - Clinical Medicine Research JF - Clinical Medicine Research JO - Clinical Medicine Research SP - 93 EP - 100 PB - Science Publishing Group SN - 2326-9057 UR - https://doi.org/10.11648/j.cmr.20190805.11 AB - There has been a limited evaluation of the efficacy of administered vitamin-D3 and bisphosphonate in a single pill (once-weekly) on changes of Bone Mineral Density (BMD), speciality in elderly people. To evaluate the changes in BMD, using Risedronate and vitamin D3, in patients from the first level of primary care after a period of more than 2 years of follow-up. An observational and retrospective cohort study, in a non-controlled, real-life setting nested to a database was designed. Records of participants between March-04-2008 and June-27-2012. Mexican patients from 21 Clinics of Family Medicine. The database is characterized by all patients received Risedronate (35 mg) and vitamin-D3 (2800 IU) combined in a single pill, administered once-weekly. BMD was determined in the distal portion of the radius bone using an Omnisense-7000S bone densitometer. The Kaplan-Meier method was used to estimate cumulative probabilities. Hazard ratios (HRs) were estimated using Cox-proportional hazard-models. A total of 14,721 women were included. The mean time of treatment was 27.06 months (interquartile-range=26.00-29.00); the crude HR in patients with osteoporosis was 2.483 (95%CI 1.806-3.414) times higher than their counterparts with osteopenia. In relation to age, the increase in BMD was 26% higher (HR=0.739; 95%CI 0.712-0.766) in patients with 60 or more age than their counterparts aged ≤59 years. The duration of treatment with risedronate/vitamin D3 once-weekly depends on the target population and need strict monitoring of BMD particularly for those patients who have a treatment for more of 18 months due to the risk of decreased BMD. VL - 8 IS - 5 ER -
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