Effects of Fat and Cinnamon Feeding on Adiponectin after Rat Injection with Dexamethasone

Mahmoud Hassan El-Bidawy; Nabil Mohamed Elbahey; Mohamed Mahmoud Shaaban

doi:doi:10.11648/j.cmr.20130206.19

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Effects of Fat and Cinnamon Feeding on Adiponectin after Rat Injection with Dexamethasone

Mahmoud Hassan El-Bidawy, Nabil Mohamed Elbahey, Mohamed Mahmoud Shaaban

Published in Clinical Medicine Research (Volume 2, Issue 6)

Received: 1 December 2013 Published: 20 December 2013

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Abstract

Chronically excessive numbers of glucocorticoids are known to induce insulin resistance, which is possibly involved in impairing the insulin signaling in liver, muscle, and adipose tissues. Excessive levels of cortisol are characterized by the symptoms of abdominal obesity, hypertension, glucose intolerance or diabetes and dyslipidemia ,all of these features are shared by the condition of insulin resistance .Consumption of high levels of dietary fat is thought to be a major factor in the promotion of obesity and insulin resistance [7]. Fatty acid composition in the diet is another mechanism implicated in the development of insulin resistance [6]. Several environmental factors, including high-fat diet, are reported to activate the functioning of the hypothalamus-pituitary-adrenal axis [HPA]. Frequently evoked HPA-axis secretes excessive amount of cortisol [21] and elevated cortisol level is implicated in the development of entire spectrum of the metabolic syndrome, including insulin resistance, visceral obesity and dyslipidemia as well as the kinds of [21]. Cinnamon contains biologically active substances that have demonstrated insulin-mimetic properties. In vitro [3] and in vivo [1, 20] studies have shown that cinnamon enhances glucose uptake by activating insulin receptor kinase activity, autophosphorylation of the insulin receptor, and glycogen synthase activity. Other recent studies have demonstrated the ability of cinnamon to reduce lipid levels in fructose-fed rats, potentially via inhibiting hepatic 3-hydroxy-3-methylglutaryl CoA reductase activity [2]. Adiponectin is the most abundant plasma protein synthesized for the most part in adipose tissue, and it is an insulin-sensitive hormone,playing a central role in glucose and lipid metabolism [7] Furthermore, adiponectin levels are inversely associated with visceral adiposity [15]. Moreover, adiponectin has been reported to exhibit anti-atherosclerotic and anti-inflammatory effects [17,16].

Published in	Clinical Medicine Research (Volume 2, Issue 6)
DOI	10.11648/j.cmr.20130206.19
Page(s)	162-166
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2013. Published by Science Publishing Group

Keywords

Fat Feeding, Cinnamon Feeding, Adiponectin, Dexamethasone

References

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[7]	Cristiane de Oliveira, Ana BM de Mattos, Carolina Biz, Lila M Oyama, Eliane B Ribeiro, and Cláudia Maria Oller do Nascimento,High-fat diet and glucocorticoid treatment cause hyperglycemia associated with adiponectin receptor alterations;Lipids in Health and Disease 2011, Volume10,pp 10:11.
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[15]	Matsuzawa Y: Establishment of a concept of visceral fat syndrome and discovery of adiponectin. Proc Jpn Acad Ser B Phys Biol Sci 2010, 86[2]:131-141.
[16]	Mousavinasab F, Tähtinen T, Jokelainen J, Koskela P, Vanhala M, Oikarinen J, Keinänen-Kiukaanniemi S: Lack of increase of serum adiponectin concentrations with a moderate weight loss during six months on a high-caloric diet in military service among a young male Finnish population. Endocrine 2005, 26[1]:65-69.
[17]	Ouchi N, Kihara S, Arita Y, Nishida M, Matsuyama A, Okamoto Y, Ishigami M, Kuriyama H, Kishida K, Nishizawa H, Hotta K, Muraguchi M, Ohmoto Y,Yamashita S, Funahashi T, Matsuzawa Y: Adipocyte-derived plasma protein, adiponectin, suppresses lipid accumulation and classAscavenger receptor expression inhuman monocyte-derived macrophages. Circulation 2001, 103:1057-1063
[18]	Plasma adiponectin concentrations in children: relationships with obesity and insulinemia. J Clin Endocrinol Metab 2001, 87[10]:4652-4656.
[19]	Stefan N, Bunt JC, Salbe AD, Funahashi T, Matsuzawa Y, Tataranni PA: Sung Hee Kim, Se Young Choung Antihyperglycemic and antihyperlipidemic action of Cinnamomi Cassiae [Cinnamon bark] extract in C57BL/Ks db/db mice Archives of Pharmacal Research February 2010, Volume 33, Issue 2, pp 325-333.
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APA Style

Mahmoud Hassan El-Bidawy, Nabil Mohamed Elbahey, Mohamed Mahmoud Shaaban. (2013). Effects of Fat and Cinnamon Feeding on Adiponectin after Rat Injection with Dexamethasone. Clinical Medicine Research, 2(6), 162-166. https://doi.org/10.11648/j.cmr.20130206.19

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ACS Style

Mahmoud Hassan El-Bidawy; Nabil Mohamed Elbahey; Mohamed Mahmoud Shaaban. Effects of Fat and Cinnamon Feeding on Adiponectin after Rat Injection with Dexamethasone. Clin. Med. Res. 2013, 2(6), 162-166. doi: 10.11648/j.cmr.20130206.19

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AMA Style

Mahmoud Hassan El-Bidawy, Nabil Mohamed Elbahey, Mohamed Mahmoud Shaaban. Effects of Fat and Cinnamon Feeding on Adiponectin after Rat Injection with Dexamethasone. Clin Med Res. 2013;2(6):162-166. doi: 10.11648/j.cmr.20130206.19

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@article{10.11648/j.cmr.20130206.19,
  author = {Mahmoud Hassan El-Bidawy and Nabil Mohamed Elbahey and Mohamed Mahmoud Shaaban},
  title = {Effects of Fat and Cinnamon Feeding on Adiponectin after Rat Injection with Dexamethasone},
  journal = {Clinical Medicine Research},
  volume = {2},
  number = {6},
  pages = {162-166},
  doi = {10.11648/j.cmr.20130206.19},
  url = {https://doi.org/10.11648/j.cmr.20130206.19},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.cmr.20130206.19},
  abstract = {Chronically excessive numbers of glucocorticoids are known to induce insulin resistance, which is possibly involved in impairing the insulin signaling in liver, muscle, and adipose tissues. Excessive levels of cortisol are characterized by the symptoms of abdominal obesity, hypertension, glucose intolerance or diabetes and dyslipidemia ,all of these features are shared by the condition of insulin resistance .Consumption of high levels of dietary fat is thought to be a major factor in the promotion of obesity and insulin resistance [7]. Fatty acid composition in the diet is another mechanism implicated in the development of insulin resistance [6]. Several environmental factors, including high-fat diet, are reported to activate the functioning of the hypothalamus-pituitary-adrenal axis [HPA]. Frequently evoked HPA-axis secretes excessive amount of cortisol [21] and elevated cortisol level is implicated in the development of entire spectrum of the metabolic syndrome, including insulin resistance, visceral obesity and dyslipidemia as well as the kinds of [21]. Cinnamon contains biologically active substances that have demonstrated insulin-mimetic properties. In vitro [3] and in vivo [1, 20] studies have shown that cinnamon enhances glucose uptake by activating insulin receptor kinase activity, autophosphorylation of the insulin receptor, and glycogen synthase activity. Other recent studies have demonstrated the ability of cinnamon to reduce lipid levels in fructose-fed rats, potentially via inhibiting hepatic 3-hydroxy-3-methylglutaryl CoA reductase activity [2]. Adiponectin is the most abundant plasma protein synthesized for the most part in adipose tissue, and it is an insulin-sensitive hormone,playing a central role in glucose and lipid metabolism [7] Furthermore, adiponectin levels are inversely associated with visceral adiposity [15]. Moreover, adiponectin has been reported to exhibit anti-atherosclerotic and anti-inflammatory effects [17,16].},
 year = {2013}
}

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TY  - JOUR
T1  - Effects of Fat and Cinnamon Feeding on Adiponectin after Rat Injection with Dexamethasone
AU  - Mahmoud Hassan El-Bidawy
AU  - Nabil Mohamed Elbahey
AU  - Mohamed Mahmoud Shaaban
Y1  - 2013/12/20
PY  - 2013
N1  - https://doi.org/10.11648/j.cmr.20130206.19
DO  - 10.11648/j.cmr.20130206.19
T2  - Clinical Medicine Research
JF  - Clinical Medicine Research
JO  - Clinical Medicine Research
SP  - 162
EP  - 166
PB  - Science Publishing Group
SN  - 2326-9057
UR  - https://doi.org/10.11648/j.cmr.20130206.19
AB  - Chronically excessive numbers of glucocorticoids are known to induce insulin resistance, which is possibly involved in impairing the insulin signaling in liver, muscle, and adipose tissues. Excessive levels of cortisol are characterized by the symptoms of abdominal obesity, hypertension, glucose intolerance or diabetes and dyslipidemia ,all of these features are shared by the condition of insulin resistance .Consumption of high levels of dietary fat is thought to be a major factor in the promotion of obesity and insulin resistance [7]. Fatty acid composition in the diet is another mechanism implicated in the development of insulin resistance [6]. Several environmental factors, including high-fat diet, are reported to activate the functioning of the hypothalamus-pituitary-adrenal axis [HPA]. Frequently evoked HPA-axis secretes excessive amount of cortisol [21] and elevated cortisol level is implicated in the development of entire spectrum of the metabolic syndrome, including insulin resistance, visceral obesity and dyslipidemia as well as the kinds of [21]. Cinnamon contains biologically active substances that have demonstrated insulin-mimetic properties. In vitro [3] and in vivo [1, 20] studies have shown that cinnamon enhances glucose uptake by activating insulin receptor kinase activity, autophosphorylation of the insulin receptor, and glycogen synthase activity. Other recent studies have demonstrated the ability of cinnamon to reduce lipid levels in fructose-fed rats, potentially via inhibiting hepatic 3-hydroxy-3-methylglutaryl CoA reductase activity [2]. Adiponectin is the most abundant plasma protein synthesized for the most part in adipose tissue, and it is an insulin-sensitive hormone,playing a central role in glucose and lipid metabolism [7] Furthermore, adiponectin levels are inversely associated with visceral adiposity [15]. Moreover, adiponectin has been reported to exhibit anti-atherosclerotic and anti-inflammatory effects [17,16].
VL  - 2
IS  - 6
ER  -

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Author Information

Mahmoud Hassan El-Bidawy

Department of Biomedical Sciences, Division of Physiology, College of Medicine, Salman bin Abdulaziz University, Al Kharj, Saudi Arabia, Department of Medical Physiology, Faculty of Medicine, Cairo University, Egypt
Nabil Mohamed Elbahey

Department of Biomedical Sciences, Division of Pharmacology, College of Medicine, Salman bin Abdulaziz University, Al Kharj, Saudi Arabia
Mohamed Mahmoud Shaaban

Department of Biomedical Sciences, Division of Histology, College of Medicine, Salman bin Abdulaziz University, Al Kharj ,Saudi Arabia

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APA Style

Mahmoud Hassan El-Bidawy, Nabil Mohamed Elbahey, Mohamed Mahmoud Shaaban. (2013). Effects of Fat and Cinnamon Feeding on Adiponectin after Rat Injection with Dexamethasone. Clinical Medicine Research, 2(6), 162-166. https://doi.org/10.11648/j.cmr.20130206.19

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ACS Style

Mahmoud Hassan El-Bidawy; Nabil Mohamed Elbahey; Mohamed Mahmoud Shaaban. Effects of Fat and Cinnamon Feeding on Adiponectin after Rat Injection with Dexamethasone. Clin. Med. Res. 2013, 2(6), 162-166. doi: 10.11648/j.cmr.20130206.19

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AMA Style

Mahmoud Hassan El-Bidawy, Nabil Mohamed Elbahey, Mohamed Mahmoud Shaaban. Effects of Fat and Cinnamon Feeding on Adiponectin after Rat Injection with Dexamethasone. Clin Med Res. 2013;2(6):162-166. doi: 10.11648/j.cmr.20130206.19

Copy | Download

@article{10.11648/j.cmr.20130206.19,
  author = {Mahmoud Hassan El-Bidawy and Nabil Mohamed Elbahey and Mohamed Mahmoud Shaaban},
  title = {Effects of Fat and Cinnamon Feeding on Adiponectin after Rat Injection with Dexamethasone},
  journal = {Clinical Medicine Research},
  volume = {2},
  number = {6},
  pages = {162-166},
  doi = {10.11648/j.cmr.20130206.19},
  url = {https://doi.org/10.11648/j.cmr.20130206.19},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.cmr.20130206.19},
  abstract = {Chronically excessive numbers of glucocorticoids are known to induce insulin resistance, which is possibly involved in impairing the insulin signaling in liver, muscle, and adipose tissues. Excessive levels of cortisol are characterized by the symptoms of abdominal obesity, hypertension, glucose intolerance or diabetes and dyslipidemia ,all of these features are shared by the condition of insulin resistance .Consumption of high levels of dietary fat is thought to be a major factor in the promotion of obesity and insulin resistance [7]. Fatty acid composition in the diet is another mechanism implicated in the development of insulin resistance [6]. Several environmental factors, including high-fat diet, are reported to activate the functioning of the hypothalamus-pituitary-adrenal axis [HPA]. Frequently evoked HPA-axis secretes excessive amount of cortisol [21] and elevated cortisol level is implicated in the development of entire spectrum of the metabolic syndrome, including insulin resistance, visceral obesity and dyslipidemia as well as the kinds of [21]. Cinnamon contains biologically active substances that have demonstrated insulin-mimetic properties. In vitro [3] and in vivo [1, 20] studies have shown that cinnamon enhances glucose uptake by activating insulin receptor kinase activity, autophosphorylation of the insulin receptor, and glycogen synthase activity. Other recent studies have demonstrated the ability of cinnamon to reduce lipid levels in fructose-fed rats, potentially via inhibiting hepatic 3-hydroxy-3-methylglutaryl CoA reductase activity [2]. Adiponectin is the most abundant plasma protein synthesized for the most part in adipose tissue, and it is an insulin-sensitive hormone,playing a central role in glucose and lipid metabolism [7] Furthermore, adiponectin levels are inversely associated with visceral adiposity [15]. Moreover, adiponectin has been reported to exhibit anti-atherosclerotic and anti-inflammatory effects [17,16].},
 year = {2013}
}

Copy | Download

TY  - JOUR
T1  - Effects of Fat and Cinnamon Feeding on Adiponectin after Rat Injection with Dexamethasone
AU  - Mahmoud Hassan El-Bidawy
AU  - Nabil Mohamed Elbahey
AU  - Mohamed Mahmoud Shaaban
Y1  - 2013/12/20
PY  - 2013
N1  - https://doi.org/10.11648/j.cmr.20130206.19
DO  - 10.11648/j.cmr.20130206.19
T2  - Clinical Medicine Research
JF  - Clinical Medicine Research
JO  - Clinical Medicine Research
SP  - 162
EP  - 166
PB  - Science Publishing Group
SN  - 2326-9057
UR  - https://doi.org/10.11648/j.cmr.20130206.19
AB  - Chronically excessive numbers of glucocorticoids are known to induce insulin resistance, which is possibly involved in impairing the insulin signaling in liver, muscle, and adipose tissues. Excessive levels of cortisol are characterized by the symptoms of abdominal obesity, hypertension, glucose intolerance or diabetes and dyslipidemia ,all of these features are shared by the condition of insulin resistance .Consumption of high levels of dietary fat is thought to be a major factor in the promotion of obesity and insulin resistance [7]. Fatty acid composition in the diet is another mechanism implicated in the development of insulin resistance [6]. Several environmental factors, including high-fat diet, are reported to activate the functioning of the hypothalamus-pituitary-adrenal axis [HPA]. Frequently evoked HPA-axis secretes excessive amount of cortisol [21] and elevated cortisol level is implicated in the development of entire spectrum of the metabolic syndrome, including insulin resistance, visceral obesity and dyslipidemia as well as the kinds of [21]. Cinnamon contains biologically active substances that have demonstrated insulin-mimetic properties. In vitro [3] and in vivo [1, 20] studies have shown that cinnamon enhances glucose uptake by activating insulin receptor kinase activity, autophosphorylation of the insulin receptor, and glycogen synthase activity. Other recent studies have demonstrated the ability of cinnamon to reduce lipid levels in fructose-fed rats, potentially via inhibiting hepatic 3-hydroxy-3-methylglutaryl CoA reductase activity [2]. Adiponectin is the most abundant plasma protein synthesized for the most part in adipose tissue, and it is an insulin-sensitive hormone,playing a central role in glucose and lipid metabolism [7] Furthermore, adiponectin levels are inversely associated with visceral adiposity [15]. Moreover, adiponectin has been reported to exhibit anti-atherosclerotic and anti-inflammatory effects [17,16].
VL  - 2
IS  - 6
ER  -

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