Background. Lymphocytic dermal infiltrations accompany the melanocytes loss in depigmenting vitiligo skin. These lymphocytes are incriminated during the pathogenesis of the disease. Fas receptor is a death receptor on the surface of cells that leads to programmed cell death (apoptosis) and FasL is its ligand. Fas/FasL system plays a crucial role in modulating apoptosis. Objectives. This study investigates the lymphocytic expression of apoptotic markers Fas/FasL in vitiligo. Methods. The present study was conducted on 45 vitiligo samples obtained from 15 vitiligo patients including 8 females (53.3%) and seven males (46.7%). Biopsies were obtained also from control volunteers. All specimens were routinely stained with Hematoxylin &Eosin and immunohistochemically for Fas & FasL apoptotic markers. Results. Fas & FasL were significantly expressed by infiltrating lymphocytes in vitiligo biopsies compared to control. Lymphocytic expression of Fas & FasL was higher on the edge biopsies than the center. Considerable lymphocytic infiltration and attack of B.M. were associated with higher lymphocytic Fas and FasL expression. During vitiligo activity lymphocytic Fas & FasL expression was also significantly higher. Conclusions. Lymphocytic Fas and FasL are significantly expressed in vitiligo patches which may trigger epidermal apoptosis and loss of melanocytes. At the same time these factors have a role in switching-off of the immune responses and cell mediated cytotoxicity.
| Published in | Clinical Medicine Research (Volume 2, Issue 5) |
| DOI | 10.11648/j.cmr.20130205.13 |
| Page(s) | 105-109 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2013. Published by Science Publishing Group |
Vitiligo, Fas, FasL, Apoptosis
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APA Style
Fatma Y. Saleh, Sherif Shoukry Awad, Irene M. Sadek. (2013). Lymphocytic Expression of Fas and FasL Apoptotic Markers in Vitiligo. Clinical Medicine Research, 2(5), 105-109. https://doi.org/10.11648/j.cmr.20130205.13
ACS Style
Fatma Y. Saleh; Sherif Shoukry Awad; Irene M. Sadek. Lymphocytic Expression of Fas and FasL Apoptotic Markers in Vitiligo. Clin. Med. Res. 2013, 2(5), 105-109. doi: 10.11648/j.cmr.20130205.13
AMA Style
Fatma Y. Saleh, Sherif Shoukry Awad, Irene M. Sadek. Lymphocytic Expression of Fas and FasL Apoptotic Markers in Vitiligo. Clin Med Res. 2013;2(5):105-109. doi: 10.11648/j.cmr.20130205.13
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Download@article{10.11648/j.cmr.20130205.13,
author = {Fatma Y. Saleh and Sherif Shoukry Awad and Irene M. Sadek},
title = {Lymphocytic Expression of Fas and FasL Apoptotic Markers in Vitiligo},
journal = {Clinical Medicine Research},
volume = {2},
number = {5},
pages = {105-109},
doi = {10.11648/j.cmr.20130205.13},
url = {https://doi.org/10.11648/j.cmr.20130205.13},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.cmr.20130205.13},
abstract = {Background. Lymphocytic dermal infiltrations accompany the melanocytes loss in depigmenting vitiligo skin. These lymphocytes are incriminated during the pathogenesis of the disease. Fas receptor is a death receptor on the surface of cells that leads to programmed cell death (apoptosis) and FasL is its ligand. Fas/FasL system plays a crucial role in modulating apoptosis. Objectives. This study investigates the lymphocytic expression of apoptotic markers Fas/FasL in vitiligo. Methods. The present study was conducted on 45 vitiligo samples obtained from 15 vitiligo patients including 8 females (53.3%) and seven males (46.7%). Biopsies were obtained also from control volunteers. All specimens were routinely stained with Hematoxylin &Eosin and immunohistochemically for Fas & FasL apoptotic markers. Results. Fas & FasL were significantly expressed by infiltrating lymphocytes in vitiligo biopsies compared to control. Lymphocytic expression of Fas & FasL was higher on the edge biopsies than the center. Considerable lymphocytic infiltration and attack of B.M. were associated with higher lymphocytic Fas and FasL expression. During vitiligo activity lymphocytic Fas & FasL expression was also significantly higher. Conclusions. Lymphocytic Fas and FasL are significantly expressed in vitiligo patches which may trigger epidermal apoptosis and loss of melanocytes. At the same time these factors have a role in switching-off of the immune responses and cell mediated cytotoxicity.},
year = {2013}
}
TY - JOUR T1 - Lymphocytic Expression of Fas and FasL Apoptotic Markers in Vitiligo AU - Fatma Y. Saleh AU - Sherif Shoukry Awad AU - Irene M. Sadek Y1 - 2013/09/20 PY - 2013 N1 - https://doi.org/10.11648/j.cmr.20130205.13 DO - 10.11648/j.cmr.20130205.13 T2 - Clinical Medicine Research JF - Clinical Medicine Research JO - Clinical Medicine Research SP - 105 EP - 109 PB - Science Publishing Group SN - 2326-9057 UR - https://doi.org/10.11648/j.cmr.20130205.13 AB - Background. Lymphocytic dermal infiltrations accompany the melanocytes loss in depigmenting vitiligo skin. These lymphocytes are incriminated during the pathogenesis of the disease. Fas receptor is a death receptor on the surface of cells that leads to programmed cell death (apoptosis) and FasL is its ligand. Fas/FasL system plays a crucial role in modulating apoptosis. Objectives. This study investigates the lymphocytic expression of apoptotic markers Fas/FasL in vitiligo. Methods. The present study was conducted on 45 vitiligo samples obtained from 15 vitiligo patients including 8 females (53.3%) and seven males (46.7%). Biopsies were obtained also from control volunteers. All specimens were routinely stained with Hematoxylin &Eosin and immunohistochemically for Fas & FasL apoptotic markers. Results. Fas & FasL were significantly expressed by infiltrating lymphocytes in vitiligo biopsies compared to control. Lymphocytic expression of Fas & FasL was higher on the edge biopsies than the center. Considerable lymphocytic infiltration and attack of B.M. were associated with higher lymphocytic Fas and FasL expression. During vitiligo activity lymphocytic Fas & FasL expression was also significantly higher. Conclusions. Lymphocytic Fas and FasL are significantly expressed in vitiligo patches which may trigger epidermal apoptosis and loss of melanocytes. At the same time these factors have a role in switching-off of the immune responses and cell mediated cytotoxicity. VL - 2 IS - 5 ER -
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