Changes in Vitamin D are Not Associated with Changes in Cardiorespiratory Fitness

Sara M. Gregory; Beth A. Parker; Jeffrey A. Capizzi; Adam S. Grimaldi; Priscilla M. Clarkson; Stephanie Moeckel-Cole; Justin Keadle; Stuart Chipkin; Linda S. Pescatello; Kathleen Simpson; C. Michael White; Paul D. Thompson

doi:doi:10.11648/j.cmr.20130204.16

Changes in Vitamin D are Not Associated with Changes in Cardiorespiratory Fitness

Sara M. Gregory, Beth A. Parker, Jeffrey A. Capizzi, Adam S. Grimaldi, Priscilla M. Clarkson, Stephanie Moeckel-Cole, Justin Keadle, Stuart Chipkin, Linda S. Pescatello, Kathleen Simpson, C. Michael White, Paul D. Thompson

Published in Clinical Medicine Research (Volume 2, Issue 4)

Received: 18 June 2013 Published: 10 July 2013

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Abstract

We investigated the relationship between changes in 25-hydroxyvitamin D (25OHD) and changes in aerobic fitness (VO2max)over 6 months in healthy adults (n = 213, mean ± SD age 44.8 ±16.4 yr, range 20-76 yr, 109 women). 25OHD status was defined as deficient (DEF: 25OHD <50 nmol•L-1, n = 16), insufficient (INS: 25OHD > 50 nmol•L-1 but < 75 nmol•L-1, n = 57), and sufficient (SUF: 25OHD >75 nmol•L-1, n = 140). Tertiles for 25OHD change were computed (lowest: < -17.5 nmol•L-1, n = 67; middle: -17.5 to 9.1 nmol•L-1, n = 75; highest: > 9.1 nmol•L-1, n = 71). Baseline 25OHD level (β = -0.003; p = 0.83) and change in 25OHD level (β = 0.01; p = 0.50) were not significant predictors of changes in VO2max. Changes in VO2maxwere similar between 25OHD status groups (p = 0.55; DEF = -1.7 ± 2.1, INS = -0.4 ± 3.2; SUF = -0.3 ± 3.1 ml•kg-1•min-1), and 25OHD change tertiles (p = 0.28; lowest = -0.3 ± 2.7, middle = -0.8 ± 3.5, highest = -0.3 ± 2.9 ml•kg-1•min-1). Changes in vitamin D over a 6-month period were not associated with changes in aerobic fitness. Aerobic fitnessis not impacted by temporal variations in 25OHD.

Published in	Clinical Medicine Research (Volume 2, Issue 4)
DOI	10.11648/j.cmr.20130204.16
Page(s)	68-72
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2013. Published by Science Publishing Group

Keywords

Maximal Oxygen Consumption, 25-Hydroxyvitamin D, Aerobic Fitness, Physical Performance

References

[1]	Barlow, C.E., et al., Cardiorespiratory fitness and long-term survival in "low-risk" adults. J Am Heart Assoc, 2012. 1(4): p. e001354.
[2]	Lyerly, G.W., et al., The association between cardiorespiratory fitness and risk of all-cause mortality among women with impaired fasting glucose or undiagnosed diabetes mellitus. Mayo Clin Proc, 2009. 84(9): p. 780-6.
[3]	Vigen, R., et al., Association of cardiorespiratory fitness with total, cardiovascular, and noncardiovascular mortality across 3 decades of follow-up in men and women. Circ Cardiovasc Qual Outcomes, 2012. 5(3): p. 358-64.
[4]	Williams, P.T., Usefulness of cardiorespiratory fitness to predict coronary heart disease risk independent of physical activity. Am J Cardiol, 2010. 106(2): p. 210-5.
[5]	Shook, R.P., et al., Cardiorespiratory fitness reduces the risk of incident hypertension associated with a parental history of hypertension. Hypertension, 2012. 59(6): p. 1220-4.
[6]	Karakas, M., et al., Low Levels of Serum 25-Hydroxyvitamin D Are Associated with Increased Risk of Myocardial Infarction, Especially in Women: Results from the MONICA/KORA Augsburg Case-Cohort Study. J Clin Endocrinol Metab, 2012.
[7]	Giovannucci, E., et al., 25-hydroxyvitamin D and risk of myocardial infarction in men: a prospective study. Arch Intern Med, 2008. 168(11): p. 1174-80.
[8]	Dobnig, H., et al., Independent association of low serum 25-hydroxyvitamin d and 1,25-dihydroxyvitamin d levels with all-cause and cardiovascular mortality. Arch Intern Med, 2008. 168(12): p. 1340-9.
[9]	Ardestani, A., et al., Relation of vitamin D level to maximal oxygen uptake in adults. Am J Cardiol, 2011. 107(8): p. 1246-9.
[10]	Grimaldi, A.S., et al., 25(OH) Vitamin D Is Associated with Greater Muscle Strength in Healthy Men and Women. Med Sci Sports Exerc, 2013. 45(1): p. 157-62.
[11]	Farrell, S.W., J.P. Cleaver, and B.L. Willis, Cardiorespiratory fitness, adiposity, and serum 25-dihydroxyvitamin d levels in men. Med Sci Sports Exerc, 2011. 43(2): p. 266-71.
[12]	Farrell, S.W. and B.L. Willis, Cardiorespiratory fitness, adiposity, and serum 25-dihydroxyvitamin D levels in women: the Cooper Center Longitudinal Study. J Womens Health (Larchmt), 2012. 21(1): p. 80-6.
[13]	Petchey, W.G., et al., Cardiorespiratory fitness is independently associated with 25-hydroxyvitamin D in chronic kidney disease. Clin J Am Soc Nephrol, 2011. 6(3): p. 512-8.
[14]	Chen, K.Y., et al., Predicting energy expenditure of physical activity using hip- and wrist-worn accelerometers. Diabetes Technol Ther, 2003. 5(6): p. 1023-33.
[15]	American College of Sports, M., ed. ACSM's Guidelines for Exercise Testing and Prescription. 8th ed. 2010, Lippincott Williams and Wilkins.
[16]	Howley, E.T., D.R. Bassett, Jr., and H.G. Welch, Criteria for maximal oxygen uptake: review and commentary. Med Sci Sports Exerc, 1995. 27(9): p. 1292-301.
[17]	Lavie, C.J., J.H. Lee, and R.V. Milani, Vitamin D and cardiovascular disease will it live up to its hype? J Am Coll Cardiol, 2011. 58(15): p. 1547-56.
[18]	Holick, M.F., et al., Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab, 2011. 96(7): p. 1911-30.
[19]	Brandenburg, V.M., M.G. Vervloet, and N. Marx, The role of vitamin D in cardiovascular disease: From present evidence to future perspectives. Atherosclerosis, 2012.
[20]	Mitsuhashi, T., R.C. Morris, Jr., and H.E. Ives, 1,25-dihydroxyvitamin D3 modulates growth of vascular smooth muscle cells. J Clin Invest, 1991. 87(6): p. 1889-95.
[21]	Bischoff, H.A., et al., In situ detection of 1,25-dihydroxyvitamin D3 receptor in human skeletal muscle tissue. Histochem J, 2001. 33(1): p. 19-24.
[22]	Houston, D.K., et al., Association between vitamin D status and physical performance: the InCHIANTI study. J Gerontol A Biol Sci Med Sci, 2007. 62(4): p. 440-6.
[23]	Ward, K.A., et al., Vitamin D status and muscle function in post-menarchal adolescent girls. J Clin Endocrinol Metab, 2009. 94(2): p. 559-63.
[24]	Jones, G., Pharmacokinetics of vitamin D toxicity. Am J Clin Nutr, 2008. 88(2): p. 582S-586S.
[25]	Heil, D.P., Predicting activity energy expenditure using the Actical activity monitor. Res Q Exerc Sport, 2006. 77(1): p. 64-80.
[26]	Hooker, S.P., et al., Validation of the actical activity monitor in middle-aged and older adults. J Phys Act Health, 2011. 8(3): p. 372-81.

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APA Style

Sara M. Gregory, Beth A. Parker, Jeffrey A. Capizzi, Adam S. Grimaldi, Priscilla M. Clarkson, et al. (2013). Changes in Vitamin D are Not Associated with Changes in Cardiorespiratory Fitness. Clinical Medicine Research, 2(4), 68-72. https://doi.org/10.11648/j.cmr.20130204.16

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ACS Style

Sara M. Gregory; Beth A. Parker; Jeffrey A. Capizzi; Adam S. Grimaldi; Priscilla M. Clarkson, et al. Changes in Vitamin D are Not Associated with Changes in Cardiorespiratory Fitness. Clin. Med. Res. 2013, 2(4), 68-72. doi: 10.11648/j.cmr.20130204.16

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AMA Style

Sara M. Gregory, Beth A. Parker, Jeffrey A. Capizzi, Adam S. Grimaldi, Priscilla M. Clarkson, et al. Changes in Vitamin D are Not Associated with Changes in Cardiorespiratory Fitness. Clin Med Res. 2013;2(4):68-72. doi: 10.11648/j.cmr.20130204.16

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@article{10.11648/j.cmr.20130204.16,
  author = {Sara M. Gregory and Beth A. Parker and Jeffrey A. Capizzi and Adam S. Grimaldi and Priscilla M. Clarkson and Stephanie Moeckel-Cole and Justin Keadle and Stuart Chipkin and Linda S. Pescatello and Kathleen Simpson and C. Michael White and Paul D. Thompson},
  title = {Changes in Vitamin D are Not Associated with Changes in Cardiorespiratory Fitness},
  journal = {Clinical Medicine Research},
  volume = {2},
  number = {4},
  pages = {68-72},
  doi = {10.11648/j.cmr.20130204.16},
  url = {https://doi.org/10.11648/j.cmr.20130204.16},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.cmr.20130204.16},
  abstract = {We investigated the relationship between changes in 25-hydroxyvitamin D (25OHD) and changes in aerobic fitness (VO2max)over 6 months in healthy adults (n = 213, mean ± SD age 44.8 ±16.4 yr, range 20-76 yr, 109 women).  25OHD status was defined as deficient (DEF: 25OHD  50 nmol•L-1 but 75 nmol•L-1, n = 140). Tertiles for 25OHD change were computed (lowest:  9.1 nmol•L-1, n = 71).  Baseline 25OHD level (β = -0.003; p = 0.83) and change in 25OHD level (β = 0.01; p = 0.50) were not significant predictors of changes in VO2max. Changes in VO2maxwere similar between 25OHD status groups (p = 0.55; DEF = -1.7 ± 2.1, INS = -0.4 ± 3.2; SUF = -0.3 ± 3.1 ml•kg-1•min-1), and 25OHD change tertiles (p = 0.28; lowest = -0.3 ± 2.7, middle = -0.8 ± 3.5, highest = -0.3 ± 2.9 ml•kg-1•min-1). Changes in vitamin D over a 6-month period were not associated with changes in aerobic fitness.  Aerobic fitnessis not impacted by temporal variations in 25OHD.},
 year = {2013}
}

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TY  - JOUR
T1  - Changes in Vitamin D are Not Associated with Changes in Cardiorespiratory Fitness
AU  - Sara M. Gregory
AU  - Beth A. Parker
AU  - Jeffrey A. Capizzi
AU  - Adam S. Grimaldi
AU  - Priscilla M. Clarkson
AU  - Stephanie Moeckel-Cole
AU  - Justin Keadle
AU  - Stuart Chipkin
AU  - Linda S. Pescatello
AU  - Kathleen Simpson
AU  - C. Michael White
AU  - Paul D. Thompson
Y1  - 2013/07/10
PY  - 2013
N1  - https://doi.org/10.11648/j.cmr.20130204.16
DO  - 10.11648/j.cmr.20130204.16
T2  - Clinical Medicine Research
JF  - Clinical Medicine Research
JO  - Clinical Medicine Research
SP  - 68
EP  - 72
PB  - Science Publishing Group
SN  - 2326-9057
UR  - https://doi.org/10.11648/j.cmr.20130204.16
AB  - We investigated the relationship between changes in 25-hydroxyvitamin D (25OHD) and changes in aerobic fitness (VO2max)over 6 months in healthy adults (n = 213, mean ± SD age 44.8 ±16.4 yr, range 20-76 yr, 109 women).  25OHD status was defined as deficient (DEF: 25OHD  50 nmol•L-1 but 75 nmol•L-1, n = 140). Tertiles for 25OHD change were computed (lowest:  9.1 nmol•L-1, n = 71).  Baseline 25OHD level (β = -0.003; p = 0.83) and change in 25OHD level (β = 0.01; p = 0.50) were not significant predictors of changes in VO2max. Changes in VO2maxwere similar between 25OHD status groups (p = 0.55; DEF = -1.7 ± 2.1, INS = -0.4 ± 3.2; SUF = -0.3 ± 3.1 ml•kg-1•min-1), and 25OHD change tertiles (p = 0.28; lowest = -0.3 ± 2.7, middle = -0.8 ± 3.5, highest = -0.3 ± 2.9 ml•kg-1•min-1). Changes in vitamin D over a 6-month period were not associated with changes in aerobic fitness.  Aerobic fitnessis not impacted by temporal variations in 25OHD.
VL  - 2
IS  - 4
ER  -

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Author Information

Sara M. Gregory

Division of Cardiology, Henry Low Heart Center, Hartford, CT, USA
Beth A. Parker

Division of Cardiology, Henry Low Heart Center, Hartford, CT, USA
Jeffrey A. Capizzi

Division of Cardiology, Henry Low Heart Center, Hartford, CT, USA
Adam S. Grimaldi

Division of Cardiology, Henry Low Heart Center, Hartford, CT, USA
Priscilla M. Clarkson

School of Public Health & HealthSciences, University of Massachusetts, Amherst, MA, USA
Stephanie Moeckel-Cole

School of Public Health & HealthSciences, University of Massachusetts, Amherst, MA, USA
Justin Keadle

School of Public Health & HealthSciences, University of Massachusetts, Amherst, MA, USA
Stuart Chipkin

School of Public Health & HealthSciences, University of Massachusetts, Amherst, MA, USA
Linda S. Pescatello

NeagSchool of Education, University of Connecticut, Storrs, CT, USA
Kathleen Simpson

NeagSchool of Education, University of Connecticut, Storrs, CT, USA
C. Michael White

NeagSchool of Education, University of Connecticut, Storrs, CT, USA
Paul D. Thompson

Division of Cardiology, Henry Low Heart Center, Hartford, CT, USA

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Plain Text BibTeX RIS

APA Style

Sara M. Gregory, Beth A. Parker, Jeffrey A. Capizzi, Adam S. Grimaldi, Priscilla M. Clarkson, et al. (2013). Changes in Vitamin D are Not Associated with Changes in Cardiorespiratory Fitness. Clinical Medicine Research, 2(4), 68-72. https://doi.org/10.11648/j.cmr.20130204.16

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ACS Style

Sara M. Gregory; Beth A. Parker; Jeffrey A. Capizzi; Adam S. Grimaldi; Priscilla M. Clarkson, et al. Changes in Vitamin D are Not Associated with Changes in Cardiorespiratory Fitness. Clin. Med. Res. 2013, 2(4), 68-72. doi: 10.11648/j.cmr.20130204.16

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AMA Style

Sara M. Gregory, Beth A. Parker, Jeffrey A. Capizzi, Adam S. Grimaldi, Priscilla M. Clarkson, et al. Changes in Vitamin D are Not Associated with Changes in Cardiorespiratory Fitness. Clin Med Res. 2013;2(4):68-72. doi: 10.11648/j.cmr.20130204.16

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@article{10.11648/j.cmr.20130204.16,
  author = {Sara M. Gregory and Beth A. Parker and Jeffrey A. Capizzi and Adam S. Grimaldi and Priscilla M. Clarkson and Stephanie Moeckel-Cole and Justin Keadle and Stuart Chipkin and Linda S. Pescatello and Kathleen Simpson and C. Michael White and Paul D. Thompson},
  title = {Changes in Vitamin D are Not Associated with Changes in Cardiorespiratory Fitness},
  journal = {Clinical Medicine Research},
  volume = {2},
  number = {4},
  pages = {68-72},
  doi = {10.11648/j.cmr.20130204.16},
  url = {https://doi.org/10.11648/j.cmr.20130204.16},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.cmr.20130204.16},
  abstract = {We investigated the relationship between changes in 25-hydroxyvitamin D (25OHD) and changes in aerobic fitness (VO2max)over 6 months in healthy adults (n = 213, mean ± SD age 44.8 ±16.4 yr, range 20-76 yr, 109 women).  25OHD status was defined as deficient (DEF: 25OHD  50 nmol•L-1 but 75 nmol•L-1, n = 140). Tertiles for 25OHD change were computed (lowest:  9.1 nmol•L-1, n = 71).  Baseline 25OHD level (β = -0.003; p = 0.83) and change in 25OHD level (β = 0.01; p = 0.50) were not significant predictors of changes in VO2max. Changes in VO2maxwere similar between 25OHD status groups (p = 0.55; DEF = -1.7 ± 2.1, INS = -0.4 ± 3.2; SUF = -0.3 ± 3.1 ml•kg-1•min-1), and 25OHD change tertiles (p = 0.28; lowest = -0.3 ± 2.7, middle = -0.8 ± 3.5, highest = -0.3 ± 2.9 ml•kg-1•min-1). Changes in vitamin D over a 6-month period were not associated with changes in aerobic fitness.  Aerobic fitnessis not impacted by temporal variations in 25OHD.},
 year = {2013}
}

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TY  - JOUR
T1  - Changes in Vitamin D are Not Associated with Changes in Cardiorespiratory Fitness
AU  - Sara M. Gregory
AU  - Beth A. Parker
AU  - Jeffrey A. Capizzi
AU  - Adam S. Grimaldi
AU  - Priscilla M. Clarkson
AU  - Stephanie Moeckel-Cole
AU  - Justin Keadle
AU  - Stuart Chipkin
AU  - Linda S. Pescatello
AU  - Kathleen Simpson
AU  - C. Michael White
AU  - Paul D. Thompson
Y1  - 2013/07/10
PY  - 2013
N1  - https://doi.org/10.11648/j.cmr.20130204.16
DO  - 10.11648/j.cmr.20130204.16
T2  - Clinical Medicine Research
JF  - Clinical Medicine Research
JO  - Clinical Medicine Research
SP  - 68
EP  - 72
PB  - Science Publishing Group
SN  - 2326-9057
UR  - https://doi.org/10.11648/j.cmr.20130204.16
AB  - We investigated the relationship between changes in 25-hydroxyvitamin D (25OHD) and changes in aerobic fitness (VO2max)over 6 months in healthy adults (n = 213, mean ± SD age 44.8 ±16.4 yr, range 20-76 yr, 109 women).  25OHD status was defined as deficient (DEF: 25OHD  50 nmol•L-1 but 75 nmol•L-1, n = 140). Tertiles for 25OHD change were computed (lowest:  9.1 nmol•L-1, n = 71).  Baseline 25OHD level (β = -0.003; p = 0.83) and change in 25OHD level (β = 0.01; p = 0.50) were not significant predictors of changes in VO2max. Changes in VO2maxwere similar between 25OHD status groups (p = 0.55; DEF = -1.7 ± 2.1, INS = -0.4 ± 3.2; SUF = -0.3 ± 3.1 ml•kg-1•min-1), and 25OHD change tertiles (p = 0.28; lowest = -0.3 ± 2.7, middle = -0.8 ± 3.5, highest = -0.3 ± 2.9 ml•kg-1•min-1). Changes in vitamin D over a 6-month period were not associated with changes in aerobic fitness.  Aerobic fitnessis not impacted by temporal variations in 25OHD.
VL  - 2
IS  - 4
ER  -

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