Analgesics are the drugs which possess significant pain relieving properties by acting on the CNS or peripheral pain receptors without significantly affecting consciousness. Lidocaine and Ropivacaine are well studied individually; but there are conflicting reports of the comparison of actions between these two drugs both in experimental and clinical trials. Total of 30 rats were taken, they were divided into six groups each containing 5 rats. The analgesic activity of drugs was studied by measuring drug-induced changes in the sensitivity of the pre-screened mice to heat stress applied to their tails (reaction time: 2-4 sec). With increasing the dose of the analgesics from 6.25 to 25µg/kg the analgesic action occurred earlier. A clinical significance is that Lidocaine has its some better analgesic effect than Ropivacaine. As known, the dose of Lidocaine for local anesthetic action is < 7mgs/kg body weight, and of Ropivacaine it is <8mgs/kg body weight. But in our study a dose of the analgesics was low, up to 25µg/kg only. Because of this low dose, the mechanism of analgesic action of the drugs is different, and it is discussed in this paper.
| Published in |
American Journal of BioScience (Volume 2, Issue 6-1)
This article belongs to the Special Issue Chemical Biology |
| DOI | 10.11648/j.ajbio.s.2014020601.11 |
| Page(s) | 1-5 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2014. Published by Science Publishing Group |
Lidocaine, Ropivacaine, Analgesics, Albino Rats
| [1] | Lynn B. Cutaneous nociceptors. In: Winlow W, Holden AV. The neurobiology of pain: Symposium of the Northern Neurobiology Group, held at Leeds on 18 April 1983. MUP; 1984. ISBN 0-7190-0996-0. p. 106. |
| [2] | John, P., Premendran, B., Jayasree, T., Siresha, J. V., Kota, K., Venkateshwarlu, P., & Sharma, V. A comparative study of certain pharmacological effects of lidocaine and ropivacaine. 2012: 2( 4), PP 54-61 |
| [3] | McClure J H. Ropivacaine. Br. J Anaesth 1996; 76:300-7. |
| [4] | McCartney, C. J., Murphy, D. B., Iagounova, A., & Chan, V. W. (2003). Intravenous ropivacaine bolus is a reliable marker of intravascular injection in premedicated healthy volunteers. Canadian Journal of Anesthesia, 50(8), 795-800. |
| [5] | Marret, Emmanuel, Yacine Ynineb, Felix Tounou-Akue, and Mihai Ott. "Place de la lidocaïne par voie intraveineuse dans la prise en charge de la douleur postopératoire." Le Praticien en Anesthésie Réanimation 15, no. 2 (2011): 104-109. |
| [6] | Du, Congwu, et al. "Detection Of Ca 2+-Dependent Neuronal Activity Simultaneously With Dynamic Changes In Cerebral Blood Volume And Tissue Oxygenation From The Live Rat Brain." Journal of Innovative Optical Health Sciences 2.02 (2009): 189-200. |
| [7] | Arpita Laha, Sarmila Ghosh, Haripada Das, Comparison of caudal analgesia between ropivacaine and ropivacaine with clonidine in children: A randomized controlled trial, Department of Anaesthesiology, 2012, 6(3), 197-200. |
| [8] | Sukhminder Jit Singh Bajwa, Jasbir Kaur, Caudal ropivacaine-clonidine: A better post-operative analgesic approach, Department of Anaesthesiology and Intensive Care, 2010; 54, (3), Page: 226-230. |
| [9] | Kolesnikov, Yuri A., Igor Chereshnev, and Gavril W. Pasternak. "Analgesic synergy between topical lidocaine and topical opioids." Journal of Pharmacology and Experimental Therapeutics 295.2 (2000): 546-551. |
| [10] | Sinha, Sandip, et al. "Comparative study of analgesic efficacy of ropivacaine with ropivacaine plus dexmedetomidine for paravertebral block in unilateral renal surgery." Anaesthesia, Pain & Intensive Care 16.1 (2012). |
| [11] | Dubuisson, David, and Stephen G. Dennis. "The formalin test: a quantitative study of the analgesic effects of morphine, meperidine, and brain stem stimulation in rats and cats." Pain 4 (1978): 161-174. |
| [12] | Saha, Achinto, and Muniruddin Ahmed. "The analgesic and anti-inflammatory activities of the extract of Albizia lebbeck in animal model." Pakistan journal of pharmaceutical sciences 22.1 (2009). |
| [13] | Premendran John, BenHur Premendran, Jayasree T, Siresha J V, Karunakar Kota,Venkateshwarlu P,Vijay Kalwa, Vijay Sharma, A comparative study of certain pharmacological effects of lidocaine and ropivacaine, IOSR Journal of Pharmacy , ISSN: 2250-3013, Vol. 2, Issue 4 (July2012), PP 54-61. |
| [14] | Camorcia M, Capogna G, Columb MO, Minimum local analgesic doses of ropivacaine, levobupivacaine, and bupivacaine for intrathecal labor analgesia, Anesthesiology. 2005 Mar; 102(3):646-50. |
APA Style
Thota. Madhu Chaithanya, MundllaMudi. Prasad Naidu. (2014). The Study of Comparative Analgesic Activity of Lidocaine and Ropivacaine on Albino Rats. American Journal of BioScience, 2(6-1), 1-5. https://doi.org/10.11648/j.ajbio.s.2014020601.11
ACS Style
Thota. Madhu Chaithanya; MundllaMudi. Prasad Naidu. The Study of Comparative Analgesic Activity of Lidocaine and Ropivacaine on Albino Rats. Am. J. BioScience 2014, 2(6-1), 1-5. doi: 10.11648/j.ajbio.s.2014020601.11
Share This Article
Twitter
Linked In
Facebook
Copy
Download@article{10.11648/j.ajbio.s.2014020601.11,
author = {Thota. Madhu Chaithanya and MundllaMudi. Prasad Naidu},
title = {The Study of Comparative Analgesic Activity of Lidocaine and Ropivacaine on Albino Rats},
journal = {American Journal of BioScience},
volume = {2},
number = {6-1},
pages = {1-5},
doi = {10.11648/j.ajbio.s.2014020601.11},
url = {https://doi.org/10.11648/j.ajbio.s.2014020601.11},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajbio.s.2014020601.11},
abstract = {Analgesics are the drugs which possess significant pain relieving properties by acting on the CNS or peripheral pain receptors without significantly affecting consciousness. Lidocaine and Ropivacaine are well studied individually; but there are conflicting reports of the comparison of actions between these two drugs both in experimental and clinical trials. Total of 30 rats were taken, they were divided into six groups each containing 5 rats. The analgesic activity of drugs was studied by measuring drug-induced changes in the sensitivity of the pre-screened mice to heat stress applied to their tails (reaction time: 2-4 sec). With increasing the dose of the analgesics from 6.25 to 25µg/kg the analgesic action occurred earlier. A clinical significance is that Lidocaine has its some better analgesic effect than Ropivacaine. As known, the dose of Lidocaine for local anesthetic action is < 7mgs/kg body weight, and of Ropivacaine it is <8mgs/kg body weight. But in our study a dose of the analgesics was low, up to 25µg/kg only. Because of this low dose, the mechanism of analgesic action of the drugs is different, and it is discussed in this paper.},
year = {2014}
}
TY - JOUR T1 - The Study of Comparative Analgesic Activity of Lidocaine and Ropivacaine on Albino Rats AU - Thota. Madhu Chaithanya AU - MundllaMudi. Prasad Naidu Y1 - 2014/07/13 PY - 2014 N1 - https://doi.org/10.11648/j.ajbio.s.2014020601.11 DO - 10.11648/j.ajbio.s.2014020601.11 T2 - American Journal of BioScience JF - American Journal of BioScience JO - American Journal of BioScience SP - 1 EP - 5 PB - Science Publishing Group SN - 2330-0167 UR - https://doi.org/10.11648/j.ajbio.s.2014020601.11 AB - Analgesics are the drugs which possess significant pain relieving properties by acting on the CNS or peripheral pain receptors without significantly affecting consciousness. Lidocaine and Ropivacaine are well studied individually; but there are conflicting reports of the comparison of actions between these two drugs both in experimental and clinical trials. Total of 30 rats were taken, they were divided into six groups each containing 5 rats. The analgesic activity of drugs was studied by measuring drug-induced changes in the sensitivity of the pre-screened mice to heat stress applied to their tails (reaction time: 2-4 sec). With increasing the dose of the analgesics from 6.25 to 25µg/kg the analgesic action occurred earlier. A clinical significance is that Lidocaine has its some better analgesic effect than Ropivacaine. As known, the dose of Lidocaine for local anesthetic action is < 7mgs/kg body weight, and of Ropivacaine it is <8mgs/kg body weight. But in our study a dose of the analgesics was low, up to 25µg/kg only. Because of this low dose, the mechanism of analgesic action of the drugs is different, and it is discussed in this paper. VL - 2 IS - 6-1 ER -
Email: