Prostate Specific Antigen (PSA) is the first line test in screening of prostate cancer. The increase in PSA depends on differentiation of tumour cells. Gleason grading is one of the most powerful predictors of biological behaviour and influential factors used to determine treatment. PSA, when combined with Gleason score and clinical stage, improves the prediction of pathological stage for prostate carcinoma. Aims of this study were to study the histopathological features and Gleason grading in Prostatic Carcinoma and to correlate pretreatment PSA levels with Gleason grade. The study was undertaken in a tertiary care hospital over a period of two years.Fifty one cases of prostatic carcinoma were studied. Grading done by Gleason grading system, was correlated with serum PSA levels. Software statistical package for social sciences (SPSS), version 16 was used. P value < 0.05 was considered significant. Patients were aged predominantly between 60 to 70 yrs. Majority (66.7%) had poorly differentiated adenocarcinoma. 84.3% had high values of PSA (>10ng/ml). 5.9 % had PSA value in normal range (< 4 ng/ml). Though there was a comparative increase in PSA level with increase in Gleason grade, it was not statistically significant (‘p’ value = 0.75). To conclude, a proportion of tumours with Gleason score 8-10 are so poorly differentiated that they produce relatively little PSA. Refinement in estimation and interpretation of PSA values may be considered to improve the sensitivity and specificity of PSA. Gleason grading is a better predictor of biological behaviour of prostate cancer.
| Published in |
Science Journal of Clinical Medicine (Volume 4, Issue 4-1)
This article belongs to the Special Issue Latest Different Concepts of Gynaecology |
| DOI | 10.11648/j.sjcm.s.2015040401.11 |
| Page(s) | 1-5 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2015. Published by Science Publishing Group |
Gleason Grade, Prostate Cancer, PSA
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APA Style
Deepika Gurumurthy, Rangaswamy Maggad, Sapna Patel. (2015). Prostate carcinoma: correlation of histopathology with serum prostate specific antigen. Science Journal of Clinical Medicine, 4(4-1), 1-5. https://doi.org/10.11648/j.sjcm.s.2015040401.11
ACS Style
Deepika Gurumurthy; Rangaswamy Maggad; Sapna Patel. Prostate carcinoma: correlation of histopathology with serum prostate specific antigen. Sci. J. Clin. Med. 2015, 4(4-1), 1-5. doi: 10.11648/j.sjcm.s.2015040401.11
AMA Style
Deepika Gurumurthy, Rangaswamy Maggad, Sapna Patel. Prostate carcinoma: correlation of histopathology with serum prostate specific antigen. Sci J Clin Med. 2015;4(4-1):1-5. doi: 10.11648/j.sjcm.s.2015040401.11
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Download@article{10.11648/j.sjcm.s.2015040401.11,
author = {Deepika Gurumurthy and Rangaswamy Maggad and Sapna Patel},
title = {Prostate carcinoma: correlation of histopathology with serum prostate specific antigen},
journal = {Science Journal of Clinical Medicine},
volume = {4},
number = {4-1},
pages = {1-5},
doi = {10.11648/j.sjcm.s.2015040401.11},
url = {https://doi.org/10.11648/j.sjcm.s.2015040401.11},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sjcm.s.2015040401.11},
abstract = {Prostate Specific Antigen (PSA) is the first line test in screening of prostate cancer. The increase in PSA depends on differentiation of tumour cells. Gleason grading is one of the most powerful predictors of biological behaviour and influential factors used to determine treatment. PSA, when combined with Gleason score and clinical stage, improves the prediction of pathological stage for prostate carcinoma. Aims of this study were to study the histopathological features and Gleason grading in Prostatic Carcinoma and to correlate pretreatment PSA levels with Gleason grade. The study was undertaken in a tertiary care hospital over a period of two years.Fifty one cases of prostatic carcinoma were studied. Grading done by Gleason grading system, was correlated with serum PSA levels. Software statistical package for social sciences (SPSS), version 16 was used. P value 10ng/ml). 5.9 % had PSA value in normal range (< 4 ng/ml). Though there was a comparative increase in PSA level with increase in Gleason grade, it was not statistically significant (‘p’ value = 0.75). To conclude, a proportion of tumours with Gleason score 8-10 are so poorly differentiated that they produce relatively little PSA. Refinement in estimation and interpretation of PSA values may be considered to improve the sensitivity and specificity of PSA. Gleason grading is a better predictor of biological behaviour of prostate cancer.},
year = {2015}
}
TY - JOUR T1 - Prostate carcinoma: correlation of histopathology with serum prostate specific antigen AU - Deepika Gurumurthy AU - Rangaswamy Maggad AU - Sapna Patel Y1 - 2015/08/03 PY - 2015 N1 - https://doi.org/10.11648/j.sjcm.s.2015040401.11 DO - 10.11648/j.sjcm.s.2015040401.11 T2 - Science Journal of Clinical Medicine JF - Science Journal of Clinical Medicine JO - Science Journal of Clinical Medicine SP - 1 EP - 5 PB - Science Publishing Group SN - 2327-2732 UR - https://doi.org/10.11648/j.sjcm.s.2015040401.11 AB - Prostate Specific Antigen (PSA) is the first line test in screening of prostate cancer. The increase in PSA depends on differentiation of tumour cells. Gleason grading is one of the most powerful predictors of biological behaviour and influential factors used to determine treatment. PSA, when combined with Gleason score and clinical stage, improves the prediction of pathological stage for prostate carcinoma. Aims of this study were to study the histopathological features and Gleason grading in Prostatic Carcinoma and to correlate pretreatment PSA levels with Gleason grade. The study was undertaken in a tertiary care hospital over a period of two years.Fifty one cases of prostatic carcinoma were studied. Grading done by Gleason grading system, was correlated with serum PSA levels. Software statistical package for social sciences (SPSS), version 16 was used. P value 10ng/ml). 5.9 % had PSA value in normal range (< 4 ng/ml). Though there was a comparative increase in PSA level with increase in Gleason grade, it was not statistically significant (‘p’ value = 0.75). To conclude, a proportion of tumours with Gleason score 8-10 are so poorly differentiated that they produce relatively little PSA. Refinement in estimation and interpretation of PSA values may be considered to improve the sensitivity and specificity of PSA. Gleason grading is a better predictor of biological behaviour of prostate cancer. VL - 4 IS - 4-1 ER -
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