Neoboutonia velutina Prain is a small tree of 6-12 m, found in tropical areas of Africa (Cameroon, Zimbabwe, Malawi, Nigeria, Angola and Southern Sudan). This plant is used in Cameroonian traditional medicine for the treatment of central nervous system diseases like epilepsy and for the treatment of hepatitis. In our knowledge, there are no published studies on biological activity of N. velutina. In the present study, in vivo animal models of epilepsy (strychnine, pentylenetetrazol and Picrotoxin-induced convulsions) and insomnia (diazepam -induced sleep) were used to evaluate the anticonvulsant and sedative properties of N. velutina. The aqueous extract of the leaves of N. velutina protected mice against strychnine (p<0.05), pentylenetetrazol (p<0.01), and picrotoxin (p<0.001)-induced seizures. The extract strongly increased the total sleep time induced by diazepam (50 mg/kg i.p.) but did not significantly precipitate the onset of sleep. The results lead to the conclusion that the extract of N. velutina possesses anticonvulsant and sedative properties in mice and could explain its use in traditional medicine for the treatment of epilepsy and insomnia.
| Published in | Journal of Diseases and Medicinal Plants (Volume 1, Issue 2) |
| DOI | 10.11648/j.jdmp.20150102.11 |
| Page(s) | 24-30 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
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Copyright © The Author(s), 2015. Published by Science Publishing Group |
Neoboutonia velutina, Aqueous Extract, Anticonvulsant, Sedative
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APA Style
Germain Jean Magloire Ketcha Wanda, Steve Guemnang Ngitedem, Sefirin Djiogue, Franklin Zemo Gamo, Dieudonne Njamen. (2015). Anticonvulsant and Sedative Properties of Leaves of Neoboutonia velutina (Euphorbiaceae) Prain in Mice. Journal of Diseases and Medicinal Plants, 1(2), 24-30. https://doi.org/10.11648/j.jdmp.20150102.11
ACS Style
Germain Jean Magloire Ketcha Wanda; Steve Guemnang Ngitedem; Sefirin Djiogue; Franklin Zemo Gamo; Dieudonne Njamen. Anticonvulsant and Sedative Properties of Leaves of Neoboutonia velutina (Euphorbiaceae) Prain in Mice. J. Dis. Med. Plants 2015, 1(2), 24-30. doi: 10.11648/j.jdmp.20150102.11
AMA Style
Germain Jean Magloire Ketcha Wanda, Steve Guemnang Ngitedem, Sefirin Djiogue, Franklin Zemo Gamo, Dieudonne Njamen. Anticonvulsant and Sedative Properties of Leaves of Neoboutonia velutina (Euphorbiaceae) Prain in Mice. J Dis Med Plants. 2015;1(2):24-30. doi: 10.11648/j.jdmp.20150102.11
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Download@article{10.11648/j.jdmp.20150102.11,
author = {Germain Jean Magloire Ketcha Wanda and Steve Guemnang Ngitedem and Sefirin Djiogue and Franklin Zemo Gamo and Dieudonne Njamen},
title = {Anticonvulsant and Sedative Properties of Leaves of Neoboutonia velutina (Euphorbiaceae) Prain in Mice},
journal = {Journal of Diseases and Medicinal Plants},
volume = {1},
number = {2},
pages = {24-30},
doi = {10.11648/j.jdmp.20150102.11},
url = {https://doi.org/10.11648/j.jdmp.20150102.11},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jdmp.20150102.11},
abstract = {Neoboutonia velutina Prain is a small tree of 6-12 m, found in tropical areas of Africa (Cameroon, Zimbabwe, Malawi, Nigeria, Angola and Southern Sudan). This plant is used in Cameroonian traditional medicine for the treatment of central nervous system diseases like epilepsy and for the treatment of hepatitis. In our knowledge, there are no published studies on biological activity of N. velutina. In the present study, in vivo animal models of epilepsy (strychnine, pentylenetetrazol and Picrotoxin-induced convulsions) and insomnia (diazepam -induced sleep) were used to evaluate the anticonvulsant and sedative properties of N. velutina. The aqueous extract of the leaves of N. velutina protected mice against strychnine (p<0.05), pentylenetetrazol (p<0.01), and picrotoxin (p<0.001)-induced seizures. The extract strongly increased the total sleep time induced by diazepam (50 mg/kg i.p.) but did not significantly precipitate the onset of sleep. The results lead to the conclusion that the extract of N. velutina possesses anticonvulsant and sedative properties in mice and could explain its use in traditional medicine for the treatment of epilepsy and insomnia.},
year = {2015}
}
TY - JOUR T1 - Anticonvulsant and Sedative Properties of Leaves of Neoboutonia velutina (Euphorbiaceae) Prain in Mice AU - Germain Jean Magloire Ketcha Wanda AU - Steve Guemnang Ngitedem AU - Sefirin Djiogue AU - Franklin Zemo Gamo AU - Dieudonne Njamen Y1 - 2015/05/28 PY - 2015 N1 - https://doi.org/10.11648/j.jdmp.20150102.11 DO - 10.11648/j.jdmp.20150102.11 T2 - Journal of Diseases and Medicinal Plants JF - Journal of Diseases and Medicinal Plants JO - Journal of Diseases and Medicinal Plants SP - 24 EP - 30 PB - Science Publishing Group SN - 2469-8210 UR - https://doi.org/10.11648/j.jdmp.20150102.11 AB - Neoboutonia velutina Prain is a small tree of 6-12 m, found in tropical areas of Africa (Cameroon, Zimbabwe, Malawi, Nigeria, Angola and Southern Sudan). This plant is used in Cameroonian traditional medicine for the treatment of central nervous system diseases like epilepsy and for the treatment of hepatitis. In our knowledge, there are no published studies on biological activity of N. velutina. In the present study, in vivo animal models of epilepsy (strychnine, pentylenetetrazol and Picrotoxin-induced convulsions) and insomnia (diazepam -induced sleep) were used to evaluate the anticonvulsant and sedative properties of N. velutina. The aqueous extract of the leaves of N. velutina protected mice against strychnine (p<0.05), pentylenetetrazol (p<0.01), and picrotoxin (p<0.001)-induced seizures. The extract strongly increased the total sleep time induced by diazepam (50 mg/kg i.p.) but did not significantly precipitate the onset of sleep. The results lead to the conclusion that the extract of N. velutina possesses anticonvulsant and sedative properties in mice and could explain its use in traditional medicine for the treatment of epilepsy and insomnia. VL - 1 IS - 2 ER -
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