Anamnestic Findings and Alanine Aminotransferase Predict Accurately Chronic HBs Antigen Carriers among Black Africans in Côte d’Ivoire (West Africa)

Alassan K. Mahassadi; Emile Allah-Kouadio; Constant Assi; Fulgence M. Y. Bathaix; Ahmad Coulibaly; Hortense Hovi; Mathieu B. Camara; Thérèse Y. Ndri

doi:doi:10.11648/j.cmr.20140302.11

Anamnestic Findings and Alanine Aminotransferase Predict Accurately Chronic HBs Antigen Carriers among Black Africans in Côte d’Ivoire (West Africa)

Alassan K. Mahassadi, Emile Allah-Kouadio, Constant Assi, Fulgence M. Y. Bathaix, Ahmad Coulibaly, Hortense Hovi, Mathieu B. Camara, Thérèse Y. Ndri

Published in Clinical Medicine Research (Volume 3, Issue 2)

Received: 4 January 2014 Published: 20 February 2014

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Abstract

Background: The high burden of viral hepatitis B (HBV) remains a challenge in Côte d’Ivoire where patients are mostly seen in hospital at the end stage of the disease. Aim: This cross sectional study is aimed at assessing the usefulness of anamnestic findings, clinical and biological factors in predicting chronic hepatitis B surface antigen (HBsAg) carriers in clinical practice. Patients and methods: The study was conducted in 230 workers (median age: 39 years, female: 20%) of government press enterprise (GPE) in 2010. Socio-demographic, clinical and biological parameters were collected. Chronic HBsAg carrier was defined as serum HBsAg positivity after 2 assessments within 6 months interval. Diagnostic accuracy of predictive factors was determined by multivariate logistic regression. Results: The prevalence of chronic HBsAg was 12.6% [95%CI: 8.61-17.60]. Chronic HBsAg carriers frequently expressed a history of hepatitis (13.8 vs 2.5%, p=0.003), or jaundice (37.9 vs 14.3, p=0.003), had slightly high level of AST (33 vs 25.5 IU/L, p=.004) and ALT (31.5 vs 22, p=<0.0001) compared to non-carriers. In multivariate analysis, age (OR: 0.93, p=0.03), history of hepatitis (OR=8.18, p=0.005), unsafe injection with boiled syringe (OR: 3.41, p=0.03), and ALT (OR=1.03, p=0.002) were predictive factors of chronic HBsAg carriers. The model yielded an AUROC of 0.793±0.06. With a cut-off <0.125, the model allowed predicting chronic HBsAg carrier with a sensitivity and negative predictive value of 78.6 and 96.1% respectively. Among 28 chronic HBsAg carriers 22(78.6%) were correctly predicted and 6(21.4%) were false negative. With a cut-off >0.5, the model showed a specificity, positive and negative predictive values of 99, 66.7 and 88.9% respectively. The model correctly classified 192(99%) workers as non-chronic HBsAg carriers and 2(1%) were misclassified. Conclusion: This study suggests that age, history of hepatitis, unsafe injection with boiled syringe combined with ALT could be used to predict chronic HBsAg carrier in Côte d’Ivoire and other endemic areas in Africa.

Published in	Clinical Medicine Research (Volume 3, Issue 2)
DOI	10.11648/j.cmr.20140302.11
Page(s)	12-16
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2014. Published by Science Publishing Group

Keywords

HBs Antigen, ALT, Hepatitis B, Sub-Saharan Africa

References

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Alassan K. Mahassadi, Emile Allah-Kouadio, Constant Assi, Fulgence M. Y. Bathaix, Ahmad Coulibaly, et al. (2014). Anamnestic Findings and Alanine Aminotransferase Predict Accurately Chronic HBs Antigen Carriers among Black Africans in Côte d’Ivoire (West Africa). Clinical Medicine Research, 3(2), 12-16. https://doi.org/10.11648/j.cmr.20140302.11

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ACS Style

Alassan K. Mahassadi; Emile Allah-Kouadio; Constant Assi; Fulgence M. Y. Bathaix; Ahmad Coulibaly, et al. Anamnestic Findings and Alanine Aminotransferase Predict Accurately Chronic HBs Antigen Carriers among Black Africans in Côte d’Ivoire (West Africa). Clin. Med. Res. 2014, 3(2), 12-16. doi: 10.11648/j.cmr.20140302.11

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AMA Style

Alassan K. Mahassadi, Emile Allah-Kouadio, Constant Assi, Fulgence M. Y. Bathaix, Ahmad Coulibaly, et al. Anamnestic Findings and Alanine Aminotransferase Predict Accurately Chronic HBs Antigen Carriers among Black Africans in Côte d’Ivoire (West Africa). Clin Med Res. 2014;3(2):12-16. doi: 10.11648/j.cmr.20140302.11

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@article{10.11648/j.cmr.20140302.11,
  author = {Alassan K. Mahassadi and Emile Allah-Kouadio and Constant Assi and Fulgence M. Y. Bathaix and Ahmad Coulibaly and Hortense Hovi and Mathieu B. Camara and Thérèse Y. Ndri},
  title = {Anamnestic Findings and Alanine Aminotransferase Predict Accurately Chronic HBs Antigen Carriers among Black Africans in Côte d’Ivoire (West Africa)},
  journal = {Clinical Medicine Research},
  volume = {3},
  number = {2},
  pages = {12-16},
  doi = {10.11648/j.cmr.20140302.11},
  url = {https://doi.org/10.11648/j.cmr.20140302.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.cmr.20140302.11},
  abstract = {Background: The high burden of viral hepatitis B (HBV) remains a challenge in Côte d’Ivoire where patients are mostly seen in hospital at the end stage of the disease. Aim: This cross sectional study is aimed at assessing the usefulness of anamnestic findings, clinical and biological factors in predicting chronic hepatitis B surface antigen (HBsAg) carriers in clinical practice. Patients and methods: The study was conducted in 230 workers (median age: 39 years, female: 20%) of government press enterprise (GPE) in 2010. Socio-demographic, clinical and biological parameters were collected. Chronic HBsAg carrier was defined as serum HBsAg positivity after 2 assessments within 6 months interval. Diagnostic accuracy of predictive factors was determined by multivariate logistic regression. Results: The prevalence of chronic HBsAg was 12.6% [95%CI: 8.61-17.60]. Chronic HBsAg carriers frequently expressed a history of hepatitis (13.8 vs 2.5%, p=0.003), or jaundice (37.9 vs 14.3, p=0.003), had slightly high level of AST (33 vs 25.5 IU/L, p=.004) and ALT (31.5 vs 22, p=0.5, the model showed a specificity, positive and negative predictive values of 99, 66.7 and 88.9% respectively. The model correctly classified 192(99%) workers as non-chronic HBsAg carriers and 2(1%) were misclassified. Conclusion: This study suggests that age, history of hepatitis, unsafe injection with boiled syringe combined with ALT could be used to predict chronic HBsAg carrier in Côte d’Ivoire and other endemic areas in Africa.},
 year = {2014}
}

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TY - JOUR
T1 - Anamnestic Findings and Alanine Aminotransferase Predict Accurately Chronic HBs Antigen Carriers among Black Africans in Côte d’Ivoire (West Africa)
AU - Alassan K. Mahassadi
AU - Emile Allah-Kouadio
AU - Constant Assi
AU - Fulgence M. Y. Bathaix
AU - Ahmad Coulibaly
AU - Hortense Hovi
AU - Mathieu B. Camara
AU - Thérèse Y. Ndri
Y1 - 2014/02/20
PY - 2014
N1 - https://doi.org/10.11648/j.cmr.20140302.11
DO - 10.11648/j.cmr.20140302.11
T2 - Clinical Medicine Research
JF - Clinical Medicine Research
JO - Clinical Medicine Research
SP - 12
EP - 16
PB - Science Publishing Group
SN - 2326-9057
UR - https://doi.org/10.11648/j.cmr.20140302.11
AB - Background: The high burden of viral hepatitis B (HBV) remains a challenge in Côte d’Ivoire where patients are mostly seen in hospital at the end stage of the disease. Aim: This cross sectional study is aimed at assessing the usefulness of anamnestic findings, clinical and biological factors in predicting chronic hepatitis B surface antigen (HBsAg) carriers in clinical practice. Patients and methods: The study was conducted in 230 workers (median age: 39 years, female: 20%) of government press enterprise (GPE) in 2010. Socio-demographic, clinical and biological parameters were collected. Chronic HBsAg carrier was defined as serum HBsAg positivity after 2 assessments within 6 months interval. Diagnostic accuracy of predictive factors was determined by multivariate logistic regression. Results: The prevalence of chronic HBsAg was 12.6% [95%CI: 8.61-17.60]. Chronic HBsAg carriers frequently expressed a history of hepatitis (13.8 vs 2.5%, p=0.003), or jaundice (37.9 vs 14.3, p=0.003), had slightly high level of AST (33 vs 25.5 IU/L, p=.004) and ALT (31.5 vs 22, p=0.5, the model showed a specificity, positive and negative predictive values of 99, 66.7 and 88.9% respectively. The model correctly classified 192(99%) workers as non-chronic HBsAg carriers and 2(1%) were misclassified. Conclusion: This study suggests that age, history of hepatitis, unsafe injection with boiled syringe combined with ALT could be used to predict chronic HBsAg carrier in Côte d’Ivoire and other endemic areas in Africa.
VL - 3
IS - 2
ER -

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Author Information

Alassan K. Mahassadi

Programme national de lutte contre les hépatites virales en C?te d’Ivoire (PNLHV)
Emile Allah-Kouadio

Programme national de lutte contre les hépatites virales en C?te d’Ivoire (PNLHV)
Constant Assi

Programme national de lutte contre les hépatites virales en C?te d’Ivoire (PNLHV)
Fulgence M. Y. Bathaix

Programme national de lutte contre les hépatites virales en C?te d’Ivoire (PNLHV)
Ahmad Coulibaly

Programme national de lutte contre les hépatites virales en C?te d’Ivoire (PNLHV)
Hortense Hovi

Dispensaire du groupe de presse ??Fraternité Matin??
Mathieu B. Camara

Service d’hépato-gastroentérologie, CHU de Cocody
Thérèse Y. Ndri

Service d’hépato-gastroentérologie, CHU de Yopougon

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APA Style

Alassan K. Mahassadi, Emile Allah-Kouadio, Constant Assi, Fulgence M. Y. Bathaix, Ahmad Coulibaly, et al. (2014). Anamnestic Findings and Alanine Aminotransferase Predict Accurately Chronic HBs Antigen Carriers among Black Africans in Côte d’Ivoire (West Africa). Clinical Medicine Research, 3(2), 12-16. https://doi.org/10.11648/j.cmr.20140302.11

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Alassan K. Mahassadi; Emile Allah-Kouadio; Constant Assi; Fulgence M. Y. Bathaix; Ahmad Coulibaly, et al. Anamnestic Findings and Alanine Aminotransferase Predict Accurately Chronic HBs Antigen Carriers among Black Africans in Côte d’Ivoire (West Africa). Clin. Med. Res. 2014, 3(2), 12-16. doi: 10.11648/j.cmr.20140302.11

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AMA Style

Alassan K. Mahassadi, Emile Allah-Kouadio, Constant Assi, Fulgence M. Y. Bathaix, Ahmad Coulibaly, et al. Anamnestic Findings and Alanine Aminotransferase Predict Accurately Chronic HBs Antigen Carriers among Black Africans in Côte d’Ivoire (West Africa). Clin Med Res. 2014;3(2):12-16. doi: 10.11648/j.cmr.20140302.11

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@article{10.11648/j.cmr.20140302.11,
  author = {Alassan K. Mahassadi and Emile Allah-Kouadio and Constant Assi and Fulgence M. Y. Bathaix and Ahmad Coulibaly and Hortense Hovi and Mathieu B. Camara and Thérèse Y. Ndri},
  title = {Anamnestic Findings and Alanine Aminotransferase Predict Accurately Chronic HBs Antigen Carriers among Black Africans in Côte d’Ivoire (West Africa)},
  journal = {Clinical Medicine Research},
  volume = {3},
  number = {2},
  pages = {12-16},
  doi = {10.11648/j.cmr.20140302.11},
  url = {https://doi.org/10.11648/j.cmr.20140302.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.cmr.20140302.11},
  abstract = {Background: The high burden of viral hepatitis B (HBV) remains a challenge in Côte d’Ivoire where patients are mostly seen in hospital at the end stage of the disease. Aim: This cross sectional study is aimed at assessing the usefulness of anamnestic findings, clinical and biological factors in predicting chronic hepatitis B surface antigen (HBsAg) carriers in clinical practice. Patients and methods: The study was conducted in 230 workers (median age: 39 years, female: 20%) of government press enterprise (GPE) in 2010. Socio-demographic, clinical and biological parameters were collected. Chronic HBsAg carrier was defined as serum HBsAg positivity after 2 assessments within 6 months interval. Diagnostic accuracy of predictive factors was determined by multivariate logistic regression. Results: The prevalence of chronic HBsAg was 12.6% [95%CI: 8.61-17.60]. Chronic HBsAg carriers frequently expressed a history of hepatitis (13.8 vs 2.5%, p=0.003), or jaundice (37.9 vs 14.3, p=0.003), had slightly high level of AST (33 vs 25.5 IU/L, p=.004) and ALT (31.5 vs 22, p=0.5, the model showed a specificity, positive and negative predictive values of 99, 66.7 and 88.9% respectively. The model correctly classified 192(99%) workers as non-chronic HBsAg carriers and 2(1%) were misclassified. Conclusion: This study suggests that age, history of hepatitis, unsafe injection with boiled syringe combined with ALT could be used to predict chronic HBsAg carrier in Côte d’Ivoire and other endemic areas in Africa.},
 year = {2014}
}

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